|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management显示文摘Chronic hepatitis B(CHB) is a major global health problem affecting an estimated 350 million people with more than 786000 individuals dying annually due to complications, such as cirrhosis, liver failure and hepatocellular carcinoma(HCC). Liver transplantation(LT) is considered gold standard for treatment of hepatitis B virus(HBV)-related liver failure and HCC. However, post-transplant viral reactivation can be detrimental to allograft function, leading to poor survival. Prophylaxis with high-dose hepatitis B immunoglobulin(HBIG) and anti-viral drugs have achieved remarkable progress in LT by suppressingviral replication and improving long-term survival. The combination of lamivudine(LAM) plus HBIG has been for many years the most widely used. However, life-long HBIG use is both cumbersome and costly, whereas long-term use of LAM results in resistant virus. Recently, in an effort to develop HBIG-free protocols, high potency nucleos(t)ide analogues, such as Entecavir or Tenofovir, have been tried either as monotherapy or in combination with low-dose HBIG with excellent results. Current focus is on novel antiviral targets, especially for covalently closed circular DNA(ccc DNA), in an effort to eradicate HBV infection instead of viral suppression. However, there are several other molecular mechanisms through which HBV may reactivate and need equal attention. The purpose of this review is to address post-LT HBV reactivation, its risk factors, underlying molecular mechanisms, and recent advancements and future of anti-viral therapy. | Ranjit Chauhan Shilpa Lingala Chiranjeevi Gadiparthi Nivedita Lahiri Smruti R Mohanty Jian Wu Tomasz I Michalak Sanjaya K Satapathy | 2018 | World Journal of Hepatology2018，10，3： | 5 |
| 2 | A micromechanical damage model for carbon fiber composites at reduced temperatures 显示文摘 | Edward C P Ranjit R P Alan R K | 2008 | Joumal of Composite Materials2008，42，19： | 1 |
| 3 | Hepatitis C virus core protein:intriguing properties and functional relevance显示文摘 | Ray RB Ray R Ranjit R | 2001 | FEMS Microbiol Lett2001，202，： | 1 |
| 4 | Microbialpopulations,fermentation end products,and aerobicstability of corn silage treated with ammonia or a pro-pionic acid-based preservative显示文摘 | Kung L J Robinson J R Ranjit N K | 2000 | Journal of DairyScience2000，83，： | 1 |
| 5 | Tyrosinase inhibitory and antileishmanial constituents from the rhizomes of Paris poly-phylla显示文摘 | Devkota KP Khan MT Ranjit R | 2007 | Nat Prod Res2007，21，4： | 1 |
| 6 | Photocatalytic reduction of nitrite on CdS显示文摘 | Ranjit K T Krishnamoorthy R Varadarajan T K | 1995 | Journal of Photochemistry and Photobiology A:Chemistry1995，，86： | 1 |
| 7 | Endovascular management of isolated axillary artery aneurysm-a case report显示文摘 | Vijayvergiya R Kumar RM Ranjit A | 2005 | Vasc Endovascular Surg2005，39，2： | 1 |
| 8 | Microbial populations, fermentation end-products, and aerobic stability of corn silage treated with ammonia or a propionic acid based preservativel显示文摘 | Kung L J Robinson J R Ranjit N K | 2000 | Journal of Dairy Science2000，83，7： | 1 |
| 9 | Serum immuno-globulin G, M and IgG:IgM ratio as predictors for o~tcome of childhod nephrotic syndrome 显示文摘 | Ranjit RR Eliza R Mohammed HR | 2009 | World J Peditr2009，5，2： | 1 |
| 10 | Suppression of apoptotic cell death by hepatitis C virus core protein显示文摘 | Ratna B R Keith M Ranjit R | 1996 | Virology1996，226，： | 1 |
| 11 | Pure robotic retrocaval ureter repair显示文摘 | Ashok K Hemal Ranjit R | 2008 | Int Braz J Urol2008，34，6： | 1 |
| 12 | An application of intuitionistic fuzzy sets in medical diagnosis显示文摘 | Supriya K D Ranjit B Akhil R R | 2001 | Fuzzy Sets and Systems2001，117，2： | 1 |
| 13 | A Quantitativestudy on the chemical composition of renal stones and their fluoride content from anantapur district, andhra pradesh, india 显示文摘 | Sai Sathish R Ranjit B Ganesh K M | 2008 | Current Science2008，94，1： | 1 |
| 14 | Structure-activity relationship studies on antileishmanial steroidal alkaloids from Sarcococca hookeriana 显示文摘 | Devkota K P Choudhary M I Ranjit R | 2007 | Nat Prod Res2007，21，： | 1 |
| 15 | Leucoscep- trines-A novel sesterterpene ~ith prolylendopeptidase inhibitory activity from Leucosceptrum canum显示文摘 | CHOUD HARY M I RANJIT R ATFA-UR-RAHMAN | 2004 | J Org Chem2004，69，8： | 1 |
| 16 | Two new leu- cosesterterpenes from Leucosceptrum canum 显示文摘 | CHOUDHARY M I RANJIT R ATI'A-UR-RAHMAN | 2007 | Z Natufforsch2007，62，： | 1 |
| 17 | An application of intuitionistic fuzzy sets in medical diagnosis显示文摘 | Ranjit B Akhil R R | 2001 | Fuzzy Sets and Systems2001，117，2： | 1 |
| 18 | Novel sestert- erpenes from Leucosceptrum canum of Nepalese origin显示文摘 | CHOUDHARY M I RANJIT R ATYA-UR-RAHMAN | 2004 | Org Lett2004，6，23： | 1 |
| 19 | Ig M ratio as predictors for outcome of childhood nephritic Syndrome显示文摘 | Ranjit RR Eliza R Mohammed HR | 2009 | World J Pediatr2009，5，： | 1 |
| 20 | Serum immunoglobulin G, M and IgG:IgM ratio as predictors for outcome of childhood nephrot- ic syndrome显示文摘 | Ranjit RR Eliza R Mohammed HR | 2009 | World J Pediatr2009，5，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员