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| 1 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 2 | Intermittent oral ZD1839(Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI), shows evidence of good tolerability and activity:Final results from a phase I study显示文摘 | Ferry D Hammond L Ranson M | 2000 | Proc Am Soc Clin Oncol2000，19，： | 1 |
| 3 | ZD1839, a selective oral epidermal growth factor receptor- tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial 显示文摘 | Ranson M Hammond L A Ferry D | 2002 | J Clin Onco2002，20，9： | 1 |
| 4 | Cloning and charac terization of two glutathione S-transferases from a DDT-resist- ant strain of Anopheles gambiae 显示文摘 | Ranson H Prapanthadara L Hemingway J | 1997 | Biochemical Journal1997，324，1： | 1 |
| 5 | ZD1839,a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor,is well tolerated and active in patients with solid,malignant tumors:results of a phase I trial 显示文摘 | Ranson M Hammond L A Ferry D | 2002 | J Clin Oncol2002，20，： | 1 |
| 6 | Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae 显示文摘 | Ranson H Rossiter L Ortelli F | 2001 | Biochem- ical Journal2001，359，： | 1 |
| 7 | Cloning, expres sion and characterization of an insect class glutathione S- transferase from Anophels dirus (Species B) 显示文摘 | Prapanthadar L Ranson H Somboon P | 1998 | Insect Bio- chemistry and Molecular Biology1998，28，： | 1 |
| 8 | Thermal Vegetation Canopy Model Studies显示文摘 | Smith G A Ranson K L Nguyen D | 1985 | Remote Sensing of Environment1985，11，： | 1 |
| 9 | Sun angle,view angle,and background effects on spectral response of simulated Balsam Fir canopies显示文摘 | Ranson K J Daughtry C S T Biehl L L | 1986 | Photogrammetric Engineering and Remote Sensing1986，52，5： | 1 |
| 10 | Functional antagonism between c-Jun and MyoD proteins: a direct physical association 显示文摘 | Ransone L Scharfamnn R | | Cell0，68，3： | 1 |
| 11 | Identification of a no- vel class of insect glutathione S-transferases involved in re- sistance to DDT in the malaria vector Anopheles gambiae 显示文摘 | Ranson H Rossiter L Ortelli F | 2001 | Biochemical Society2001，359，： | 1 |
| 12 | Clo- ning and characterization of two glutathione S-transferases from a DDT-resistant strain of Anopheles gambiae 显示文摘 | RANSON H PRAPANTHADARA L HEMINGWAY J | 1997 | Biochemical Journal1997，324，1： | 1 |
| 13 | fos-jun conspiracy:implications for the cell显示文摘 | Verma I M Ransone L J Visvader J | | 0，，06： | 1 |
| 14 | Identification of a Novel Class of Insect Glutathione-S-transferases Involved in Resistance to DDT in the Malaria Vector Anpheles gambiae显示文摘 | RANSON H ROSSITER L ORTELLI F | 2001 | Biochem2001，359，： | 1 |
| 15 | Intravitreal triamcinolone in subfoveal recurrence of choroidal neovascularisation after laser treatment in macular degeneration 显示文摘 | Ranson NT Danis Rp Ciulla TA Pratt L | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 16 | Lessons from the past : managing insecticide resistance in malaria control and eradication- programmes 显示文摘 | KELLY-HOPE L RANSON H HEMINGWAY J | 2008 | Lancet Infect Dis2008，8，6： | 1 |
| 17 | Thermal Vegetation Canopy Model Studies显示文摘 | Smith G A Ranson K L Nguyen D | 1985 | Remote Sensing of Environment1985，11，： | 1 |
| 18 | The Iaunbertian assumption and Landsat data 显示文摘 | Smith J A Lin T L Ranson K L | 1980 | Photogrammetric Engineering and Remote Sens- ing1980，46，9： | 1 |
| 19 | The Lambertian assumption and Landsat data显示文摘 | Smith J A Lin T L Ranson K J | 1980 | Photogrammetric Engineering and Remote Sensing1980，46，： | 1 |
| 20 | ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial显示文摘 | Ranson M Hammond L A Ferry D | 2002 | J Clin Oncol2002，20，9： | 1 |
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