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| 1 | High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease显示文摘AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood culture.RESULTS:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot assays.All 69 cultures were negative by acid-fast Ziehl-Neelsen staining.Viable MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD controls.No association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide polymorphisms.CONCLUSION:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD patients.However,MAP spheroplasts were only found in CD patients. | Juan L Mendoza Amparo San-Pedro Esther Culebras Raquel Cíes Carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre Juan J Picazo Manuel Díaz-Rubio | 2010 | World Journal of Gastroenterology2010，16，36： | 5 |
| 2 | The ρ-variation of the Hermitian Riesz Transform显示文摘在这份报纸,我们在 Hilbert 变换和与尺寸 1 的 Hermite 操作符联系的 Riesz 变换的摆动和变化的加权的 L p 空格证明行为。我们证明这个操作员印射 L p (? , w (x) dx ) 进自己 w 什么时候是在 A 的重量为 1 的 p 班 < p < 鈭吗?为 p = 1 我们为 A 得到弱类型 1 个班。加权估计也在极端情况 p = 鈭被获得?关键词摆动 -- 蟻 - 变化单个的 integral-Hermite 操作员先生(2000 ) 题目分类 42B20 - Ministerio de Educaci 贸 n y Ciencia (西班牙) 支持的 42C05,资助 MTM 2008-066621-C02-01/02 和会议 de Andaluc 铆 a,资助 FQM-354 和 P06-FQM-01509;第一个作者被 Fundaci 贸 n 卡罗来纳, Ministerio de Cultura y Educaci 贸 n de la 议员煤 b lica 阿根廷和 Universidad Nacional del Comahue | Raquel CRESCIMBENI Francisco Javier MARTíN-REYES Alberto DE LA TORRE José L.TORREA | 2010 | Acta Mathematica Sinica,English Series2010，26，10： | 2 |
| 3 | Inflammatory biomarkers and prediction for intensive care unit admission in severe community-acquired pneumonia显示文摘 | Paula Ramírez Miquel Ferrer Verónica Martí Soledad Reyes Raquel Martínez Rosario Menéndez Santiago Ewig Antoni Torres | 2011 | Critical Care Medicine2011，，10： | 1 |
| 4 | Systemic inflammatory response and increased risk for ventilator-associated pneumonia: A preliminary study显示文摘 | Paula Ramírez Miquel Ferrer Ricardo Gimeno Sergi Tormo Mauricio Valencia Raquel Pi?er Rosario Menendez Antoni Torres | 2009 | Critical Care Medicine2009，，5： | 1 |
| 5 | The Role of the Solar Cycle in the Relationship Between the North Atlantic Oscillation and Northern Hemisphere Surface Temperatures显示文摘北方大西洋摆动(NAO ) 是在北半球的气候可变性的领先的模式之一。它清楚地在气象学的变量联系到变化,这被显示出,例如地面温度,在半球的规模。然而,最近的研究表明了 NAO 空间模式也取决于太阳的强迫。因此,它气象学的变量上的效果必须变化取决于这个因素。而且,它能是阳光通过可变性模式影响气候,是这研究的焦点的一个假设。我们发现在 NAO/AO 和半球的温度之间的关系变化取决于太阳活动。结果看积极重要关联太阳活动是否仅仅高。另外,结果支持那项太阳活动影响对流的想法在经由同温层的极的旋涡的变化的北半球的球的气候变化。 | Laura DE LA TORRE Luis GIMENO Juan Antonio AEL Raquel NIETO | 2007 | Advances in Atmospheric Sciences2007，24，2： | 0 |
| 6 | Hospitalizations and in-hospital mortality for inflammatory bowel disease in Brazil显示文摘BACKGROUND Inflammatory bowel disease(IBD)is associated with complications,frequent hospitalizations,surgery and death.The introduction of biologic drugs into the therapeutic arsenal in the last two decades,combined with an expansion of immunosuppressant therapy,has changed IBD management and may have altered the profile of hospitalizations and in-hospital mortality(IHM)due to IBD.AIM To describe hospitalizations from 2008 to 2018 and to analyze IHM from 1998 to 2017 for IBD in Brazil.METHODS This observational,retrospective,ecological study used secondary data on hospitalizations for IBD in Brazil for 2008-2018 to describe hospitalizations and for 1998-2017 to analyze IHM.Hospitalization data were obtained from the Hospital Information System of the Brazilian Unified Health System and population data from demographic censuses.The following variables were analyzed:Number of deaths and hospitalizations,length of hospital stay,financial costs of hospitalization,sex,age,ethnicity and type of hospital admission.RESULTS There was a reduction in the number of IBD hospitalizations,from 6975 admissions in 1998 to 4113 in 2017(trend:y=-0.1682x+342.8;R^(2)=0.8197;P<0.0001).The hospitalization rate also decreased,from 3.60/100000 in 2000 to 2.17 in 2010.IHM rates varied during the 20-year period,between 2.06 in 2017 and 3.64 in 2007,and did not follow a linear trend(y=-0.0005049x+2.617;R^(2)=0,00006;P=0.9741).IHM rates also varied between regions,increasing in all but the southeast,which showed a decreasing trend(y=-0.1122x+4.427;R^(2)=0,728;P<0.0001).The Southeast region accounted for 44.29%of all hospitalizations.The Northeast region had the highest IHM rate(2.86 deaths/100 admissions),with an increasing trend(y=0.1105x+1.110;R^(2)=0.6265;P<0.0001),but the lowest hospitalization rate(1.15).The Midwest and South regions had the highest hospitalization rates(3.27 and 3.17,respectively).A higher IHM rate was observed for nonelective admissions(2.88),which accounted for 81%of IBD hospitalizations.The total cost of IBD hospitalizations in 2017 exhibited an increase of 37.5%compared to 2008.CONCLUSION There has been a notable reduction in the number of hospitalizations for IBD in Brazil over 20 years.IHM rates varied and did not follow a linear trend. | Ana Luiza Vilar Guedes Amanda Lopes Lorentz Larissa Fernandes de Almeida Rios Rios Beatriz Camara Freitas Adriano Gutemberg Neves Dias Ana Luísa Eckhard Uhlein Felipe Oliveira Vieira Neto Jobson Felipe Soares Jesus Túlio de SáNovaes Torres Raquel Rocha Vitor D Andrade Genoile Oliveira Santana | 2022 | World Journal of Gastrointestinal Pharmacology and Therapeutics2022，13，1： | 0 |
| 7 | Type XIX collagen: a promising biomarker from the basement membranes显示文摘Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological roles.Type XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this superfamily.This collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different tissues.The molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to NC6.The most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of cancer.Under physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in brain.Notwithstanding,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic properties.Type XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis patients.This novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis. | Ana C.Calvo Laura Moreno Leticia Moreno Janne M.Toivonen Raquel Manzano Nora Molina Miriam de la Torre Tresa López Francisco J.Miana-Mena María J.Munoz Pilar Zaragoza Pilar Larrodé Alberto García-Redondo Rosario Osta | 2020 | Neural Regeneration Research2020，15，6： | 0 |
| 8 | Verilog-A模型为微波商用仿真器增添新动力(一)显示文摘随着微波通信技术的长期发展,它将从功能上在传统的计算设备和常规的射频及微波通信仿真器中得到设计和仿真(如SPICE、Agilent ADSTM、Agilent GENESYSTM、AWR Microwave Office等)。这就使得数字计算机与设计人员以及与周围的一切进行交互和仿真成为了可能。本文旨在介绍有源微波器件建模技术在采用Verilog-A语言之后所实现的简单易用性,并使用不同的商用仿真器借助几个实例加以讨论(Agilent ADSTM和GENESYSTM,两者均选自安捷伦科技公司)。 | J.M.Zamanillo P.L.López-Espí Isabel Zamanillo Raquel Torres Jose Campelo Angel Mediavilla C.Pérez-Vega | 2009 | 国外电子测量技术2009，28，7： | 0 |
| 9 | Verilog-A模型为微波商用仿真器增添新动力(二)显示文摘4结果
作为VerilogA语言对微波电路进行建模的可移植性和精确度结果的实例,图1显示了微波二极管的仿真结果。表1显示的源文件经过Agilent ADS^TM年口GENESYS^TM微波仿真器进行了针对直流和散射的仿真。 | J.M. Zamanillo P.L. Lopez-Espi Isabel Zamanillo Raquel Torres Jose Campelo Angel Mediavilla C. Perez-Vega | 2009 | 国外电子测量技术2009，28，8： | 0 |
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