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| 1 | Antiviral innate immunity pathways显示文摘最近的研究揭开了激活主人的二个发信号小径对病毒的感染的天生的免疫。小径之一利用像使用费的受体(TLR ) 的成员检测通过 endocytosis 进入内涵体的病毒的家庭。TLR 小径通过最终导致抄写因素 NF-kappaB, IRF3 和 IRF7 的激活的几发信号的蛋白质导致干扰素生产。另外的抗病毒的小径为细胞内部的病毒的双 stranded RNA 把 RNA helicase RIG-I 用作受体。RIG-I 通过最近识别的适配器蛋白质 MAVS 激活 NF-kappaB 和 IRF,包含居住在 mitochondrial 膜的蛋白质的一个卡片领域。MAVS 为抗病毒的天生的免疫是必要的,但是它也用作丙肝病毒(HCV ) 的一个目标,它采用病毒的朊酶劈开 MAVS 离开线粒体,从而允许 HCV 逃离主人免疫系统。 | Rashu B Seth Lijun Sun Zhijian J Chen | 2006 | Cell Research2006，16，2： | 45 |
| 2 | Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3显示文摘 | Rashu B. Seth Lijun Sun Chee-Kwee Ea Zhijian J. Chen | 2005 | Cell2005，，5： | 2 |
| 3 | The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses显示文摘 | Qinmiao Sun Lijun Sun Hong-Hsing Liu Xiang Chen Rashu B. Seth James Forman Zhijian J. Chen | 2006 | Immunity2006，，5： | 1 |
| 4 | Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF33显示文摘 | Rashu B Seth Lijun Sun Chee - Kwee Ea | 2005 | Cell2005，122，： | 1 |
| 5 | Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera 显示文摘 | Arifuzzaman M Rashu R Leung DT | 2012 | Clin Vaccine Immunol2012，19，8： | 1 |
| 6 | Cholesteryl ester storage disease of clinical and genetic characterisation: A case report and review of literature显示文摘BACKGROUND Cholesteryl ester storage disease(CESD)is a rare genetic disease.Its symptoms and severity are highly variable.CESD is a systemic disease that can lead to the accumulation of fat and inflammation in the liver,as well as gastrointestinal and cardiovascular disease.The majority of patients require liver transplantation due to decompensated cirrhosis.Enzyme replacement therapy has been approved based on a randomized trial.Our study aims to clinically and genetically evaluate two siblings with CESD who underwent liver transplantation,as well as their first-degree family members.CASE SUMMARY The siblings were compound heterozygous for the missense variant in LIPA exon 8,c.894G>A,(p.Gln298Gln)and a single base pair deletion,c.482del(p.Asn161Ilefs*19).Analyses of single nucleotide polymorphisms showed variants with an increased risk of fatty liver disease and fibrosis for both patients.Clinically,both patients show signs of recurrence of CESD in the liver after transplantation and additional gastrointestinal and cardiovascular signs of CESD.Three family members who were LIPA heterozygous had a lysosomal acid lipase activity below the reference value.One of these carriers,a seven-year-old boy,was found to have severe dyslipidemia and was subsequently treated with statins.CONCLUSION Our study underlines that CESD is a multi-organ disease,the progression of which may occur post-liver transplantation.Our findings underline the need for monitoring of complications and assessment of possible further treatment. | Elias Badal Rashu Anders Ellekær Junker Karen Vagner Danielsen Emilie Dahl Ole Hamberg Line Borgwardt Vibeke Brix Christensen Nicolai J Wewer Albrechtsen Lise L Gluud | 2020 | World Journal of Clinical Cases2020，8，9： | 0 |
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