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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | The capacity of nondigestible carbohydrates to stimulate fecal bifid bacteria in healthy humans: a douhle-hlind, randomized, placebo-eont rolled, parallel-group, dose-responder elation study显示文摘 | Bouhnik Y Raskine L Simoneau G | 2004 | A- merican Journal of Clinical Nutrition2004，80，6： | 1 |
| 3 | The role of EDTA in lead transport and accumulation by Indian Mustard显示文摘 | VASSIL A D KAPULNIK Y RASKIN I | 1998 | Plant Physiol1998，117，： | 1 |
| 4 | The Role of EDTA in Lead Trans-port and Accumulation by Indian Mustard显示文摘 | Vassil A D Kapulnik Y Raskin L | 1998 | Plant Physoil1998，117，： | 1 |
| 5 | Headache may arise from perturbation of brain显示文摘 | Raskin NH Hosobuchi Y Lamb S | 1987 | Headache1987，27，8： | 1 |
| 6 | The role of EDTA in lead transport and accumulation by Indian mustard显示文摘 | Vassil A D Kapulnik Y Raskin I | 1998 | Plant Physioh1998，117，： | 1 |
| 7 | Steady-state measurement of wafer bonding cracking resistance显示文摘 | Bertholet Y Ikerb F Raskin J P | 2004 | Sensors and Actuators2004，，110： | 1 |
| 8 | The role of EDTA in lead transport and accumulation by Indian mustard显示文摘 | VASSIL A D KAPULNIK Y RASKIN I | 2004 | Plant Physiology2004，117，： | 1 |
| 9 | The capacity of nondi- gestible carbohydrates to stimulate fecalbifidobacteria in healthy humans: a double-blind, ran-domized, placebo-controlled, paral- lel-group, dose- response relation study显示文摘 | Botthnik Y Raskine L Simoneau O | 2004 | Am J Clin Nutr2004，80，6： | 1 |
| 10 | Exposure to extremely high comcentration of carbon dioxide 显示文摘 | Halpem P Raskin Y Sorkine P | 2004 | Ann Emerg Med2004，43，： | 1 |
| 11 | The role of EDTA in lead transport and accumulation by Indian Mustard显示文摘 | Vassil A D Kapulnik Y Raskin I | 1998 | Plant Physiol1998，117，： | 1 |
| 12 | Duloxetine for patients with diabetic peripheral neuropathic pain:a 6-month open-label safety study显示文摘 | RASKIN J WANG F PRITCHETT Y L | 2006 | Pain Med2006，7，5： | 1 |
| 13 | The role of EDTA in lead transport and accumulation by Indian mustard 显示文摘 | Vassil A D Kapulnik Y Raskin I | 1998 | Plant Physiology1998，117，2： | 1 |
| 14 | Ozone-induced responses in Arabidopsis thaliana:The role of salicylic acid in the accumulation of defense-relative transcripts and induced resistance显示文摘 | SHARMA Y K LE(O)N J RASKIN I | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 15 | Crucial role of aldose reductase activity and plasma glucose level in sorbitol accumulation in erythrocytes from diabetic patients显示文摘 | Hamada Y Kitoh R Raskin P | 1991 | Diabetes1991，40，： | 1 |
| 16 | The role of EDTA in lead transport and accumulation by Indian mustard显示文摘 | Vassil A D Kapulnik Y Raskin I | 1998 | Plant Physiology1998，117，： | 1 |
| 17 | Prospective,randomized,parallel-group trial to evaluate the effects of lactulose and polyethylene glycol-4000 on colonic flora in chronic idiopathic constipation显示文摘 | Bouhnik Y Neut C Raskine L | 2004 | Aliment Pharmacol Ther2004，19，8： | 1 |
| 18 | The role of EDTA in lead transport and accumulation in Indian mustard显示文摘 | Vassil A D Kapulnik Y Raskin I | 2004 | Plant Physiology2004，117，2： | 1 |
| 19 | Increased activity of erythrocyte aldose reductase in insulin-dependent diabetes with severe diabetic complications显示文摘 | Hamada Y Kitoh R Raskin P | 1991 | Diabetes1991，40，1： | 1 |
| 20 | Ozone - induced responses in Ar- abidopsis thaliana : the role of salicylic acid in the accumulation of de- fense related transcripts and induced resistance 显示文摘 | Sharma Y J Leon J Raskin I | 1996 | Proc Nat Acad Sei1996，93，： | 1 |
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