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32篇 您的检索式：作者名="Rath U"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	A Novel Polyurethane Adhesive Based on Hydroxyl-Terminated Polybatadiene显示文摘	PATRI M RATH S K SURYAVANSI U G	2006	Journal of Applied Polymer Science2006，99，：	1
3	From physiology to dis- ease and targeted therapy: interleukin-6 in inflammation and in- flammation-associated carcinogenesis显示文摘	Rath T Billmeier U Waldner MJ	2015	Arch Toxicol2015，89，4：	1
4	Influence of inseminate components on porcine leucocyte migration in vitro and in vivo after pre- and post-ovulatory insemination 显示文摘	Taylor U Schuberth H J Rath D	2009	Reprod Dom Anim2009，44，：	1
5	Neurosurgical management of thoracic and lumbar vertebral osteomyelitis and discitis in adults:a review of 43 consecutive surgically treated patients显示文摘	Rath SA Neff U Schneider O		0，，05：	1
6	Final results of a randomised trial comparing ' Tomudex' (rahitrexed) with 5fluorouracil plus leucovorin in advanced eolorectal cancer显示文摘	Cunningham D Zaleberg JR Rath U	1996	Ann Oneo11996，7，9：	1
7	Tomudex(ZD1694):results of a randomised trial in advanced colorectai cancer demon-strate efficacy and reduced mucositis and leucopenia显示文摘	Zalcberg JR Rath U	1995	Eur J Cancer1995，31，12：	1
8	A novel polyurethane sealant based on hydroxyl-terminated polybutadiene 显示文摘	Patti M Rath S K Suryavansi U G	2006	Journal of Applied Polymer Science2006，99，3：	1
9	Lasers with optical feedback as displacement sensors 显示文摘	Smith J A Rathe U W Burger C P	1995	Opt En1995，34，9：	1
10	Phase morphology and surface properties of moisture cured polyurethane-urea(MCPU) coatings:Effect of catalysts显示文摘	Rath S K Ishack A M Suryavansi U G	2008	Progress in Organic Coatings2008，62，4：	1
11	Phase morphology and surface properties of moisture cured polyurethane-urea (MCPU) coatings: Effect of eatalysts显示文摘	Rath S K Ishack A M Suryavansi U G	2008	Progress in Organic Coatings2008，62，4：	1
12	Application of factor and cluster analysis for characterization of river and estuarine water systems-a case study:Mahanadi River (India)显示文摘	PANDA U C SUNDARAY S K RATH P NAYAK B B BHATTA D	2006	Journal of Hydrol2006，331，34：	1
13	Central retinal artery occlusion after peribulbar anesthesia 显示文摘	Vinerovsky A Rath EZ Rehany U	2004	J Cataract Refract Surg2004，30，4：	1
14	Mossbauer studies of nanosize Mn1-xZnxFe2O4 显示文摘	Uadhyay C U Verma H C Rath C	2001	Journal of Alloys and Compounds2001，326，：	1
15	Oxi- datively modified LDL particles in the human placenta in early and late onset intrauterine growth restriction 显示文摘	Pecks U Rath W Caspers R	2013	Placenta2013，34，12：	1
16	Neurosurgical management of thoracic and lumbar vertebral osteomyelitis and discitis in adults:a review of 43 consecutive surgically treated patients显示文摘	Rath SF Neff U Schneider O	1996	Neurosurgery1996，38，5：	1
17	Lasers with optical feedback as displacement sensors 显示文摘	Smith J A Rathe U W Burger C P	1995	Optical Engineering1995，34，9：	1
18	Final results of a randomised trial comparing ‘Tomudex' (rahitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer显示文摘	Cunningham D Zaleberg JR Rath U	1996	Ann Oncol1996，7，：	1
19	Final results of a randomised trail comparing 'Tomudex' (raltitrexed) with 5 fluorouracil plus leucovorin in advanced colorectal cancer 显示文摘	Cunningham D Zalcberg JR Rath U	1996	Ann Oncol1996，7，9：	1
20	Nanostructures and defects in silicon-hydrogen alloys prepared by argon dilution显示文摘	DAS U K MIDDYA A R RATH J K LONGEAUD C WILLIAMSON D L CHAUDHURI P	2000	J Non-cryst Solids2000，276，1：	1

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