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| 1 | Present and future of metastatic colorectal cancer treatment: A review of new candidate targets显示文摘In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon. | Giulia Martini Teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia Maria Della Corte Floriana Morgillo Antonio Raucci Antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli | 2017 | World Journal of Gastroenterology2017，23，26： | 7 |
| 2 | Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococ- cus aureus: use of this peptide sequence in the synthesis of biologically active peptides 显示文摘 | Signas C Raucci G Jonsson K | 1989 | Proce Nat Acad Sci1989，86，2： | 1 |
| 3 | Alarmin(g) news about danger:workshop on innate danger signals and HMGB1显示文摘 | Harris HE Raucci A | 2006 | EMBO Rep2006，7，8： | 1 |
| 4 | Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma显示文摘 | Raucci R Colonna G Guerriero E | | 0，，04： | 1 |
| 5 | Mineralized collagen-modified PMMA cement enhances bone integration and reduces fibrous encapsulation in the treatment of lumbar degenerative disc disease显示文摘As a minimally invasive surgery,percutaneous cement discoplasty(PCD)is now contemplated to treat lumbar disc degeneration disease in elder population.Here,we investigated whether the osteogenic mineralized collagen(MC)modified polymethylmethacrylate(PMMA)cement could be a suitable material in PCD surgery.Injectability,hydrophilicity and mechanical properties of the MC-modified PMMA(PMMA-MC)was characterized.The introduction of MC did not change the application and setting time of PMMA and was easy to be handled in minimally invasive operation.Hydrophilicity of PMMA-MC was greatly improved and its elastic modulus was tailored to complement mechanical performance of bone under dynamic stress.Then,PCD surgery in a goat model with induced disc degeneration was performed with implantation of PMMA-MC or PMMA.Three months after implantation,micro-computed tomography analysis revealed a 36.4%higher circumferential contact index between PMMA-MC and bone,as compared to PMMA alone.Histological staining confirmed that the surface of PMMA-MC was in direct contact with new bone,while the PMMA was covered by fibrous tissue.The observed gathering of macrophages around the implant was suspected to be the cause of fibrous encapsulation.Therefore,the interactions of PMMA and PMMA-MC with macrophages were investigated in vitro.We discovered that the addition of MC could hinder the proliferation and fusion of the macrophages.Moreover,expressions of fibroblaststimulating growth factors,insulin-like growth factor,basic fibroblast growth factor and tumor necrosis factor-b were significantly down-regulated in the macrophages cocultured with PMMA-MC.Together,the promoted osteointegration and reduced fibrous tissue formation observed with PMMA-MC material makes it a promising candidate for PCD surgery. | Long Yang Jianjun Kong Zhiye Qiu Tieliang Shang Siyu Chen Rui Zhao Maria Grazia Raucci Xiao Yang Zhanyong Wu | 2020 | Regenerative Biomaterials2020，7，2： | 1 |
| 6 | Posterior fossa vestibular neurotomy as primary surgical treatment of Meniere's disease: a re-evaluation 显示文摘 | PARESCHI R DESTITO D FALCO RAUCCI A | 2006 | J Laryngol Otol2006，116，13： | 1 |
| 7 | Emergency department treatment of severe asthma:metered-dose inhaler plus holding chamber is equivalent in effectiveness to nebulizer显示文摘 | Idris AH McDermott MF Raucci JC | 1993 | Chest1993，103，： | 1 |
| 8 | A soluble form of the receptor for advanced glyeation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)显示文摘 | Raucci A Cugusi S Antonelli A | 2008 | Faseb J2008，22，10： | 1 |
| 9 | Biomineralized porous composite scaffolds prepared by chemical synthesis for bone tissue regeneration 显示文摘 | Raucci MG Anto VD Guarino V | 2010 | Acta Biomater2010，6，398： | 1 |
| 10 | A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)显示文摘 | Raucci A Cugusi S Antonelli A | 2008 | Faseb J2008，22，10： | 1 |
| 11 | HMGBI prmnotes re- cruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4显示文摘 | Schiraldi M Raucci A Munoz L M | 2012 | J Exp Med2012，209，3： | 1 |
| 12 | lnduced maturation of frog mast cells by nerve growth factor during ontogenesis 显示文摘 | Baccari GC Raucci F Di Fiore MM et ol | 2003 | Microsc Res Tech2003，62，5： | 1 |
| 13 | HMGB1:A signal of necrosis显示文摘 | Raucci A Palumbo R Bianchi M E | 2007 | Autoimmunity2007，40，4： | 1 |
| 14 | HMGB 1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 显示文摘 | Schiraldi M Raucci A Mufioz LM | 2012 | JExp Med2012，209，3： | 1 |
| 15 | Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes显示文摘 | Raucci A Laplantine E Mansukhani A | 2004 | J Biol Chem2004，279，3： | 1 |
| 16 | A soluble form of the receptor for advanced glycation end products(RAGE)is produced by proteolytic cleavage of the membrane bound form by the sheddase a disintegrin and metalloprotease 10(ADAM10)显示文摘 | Raucci A Cugusi S Antonelli A | 2008 | FASEB J2008，22，10： | 1 |
| 17 | Stimulation of androgenproduction by D-aspartate through the enhancement of StAR,P450scc and 3/~-HSD mRNA levels in vivo rat tes- tis and in culture of immature rat Leydig cells显示文摘 | Raucci F DPaniello A Fiore MM | 2014 | Ster- oids2014，，10： | 1 |
| 18 | Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways显示文摘 | Angela Raucci Paola Bellosta Roberta Grassi | 2008 | J Cell Physiol2008，215，2： | 1 |
| 19 | Functional and structuralfeatures of adipokine family显示文摘 | Raucci R Rusolo F Sharma A | 2013 | Cytokine2013，61，1： | 1 |
| 20 | HMGB1:a signal ofnecrosis显示文摘 | Raucci A Palumbo R Bianchi M E | 2007 | Autoimmunity2007，40，4： | 1 |
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