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| 1 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 14 |
| 2 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 3 | Mechanisms of fibrinolysis resistance and potential targets for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli显示文摘There has been growing interest and insight into the histological composition of retrieved stroke emboli.One of the main focuses of the stroke clot analysis literature has been the implications of clot composition on mechanical thrombectomy procedures.However,the holy grail of clot analysis may not be in the field of clot-device interaction,but rather,in understanding mechanisms of fibrinolysis resistance.The mechanisms underlying the low response to fibrinolytic therapy,even with the newer,more powerful agents,remain poorly understood.While factors such as embolus size,location and collateral status influence alteplase delivery and recanalisation rates;compositional analyses focused on histological and ultrastructural characteristics offer unique insights into mechanisms of alteplase resistance.In this review,we strive to provide comprehensive review of current knowledge on clot composition and ultrastructural analyses that help explain resistance to fibrinolysis. | Waleed Brinjikji Oana Madalina Mereuta Daying Dai David F Kallmes Luis Savastano Yang Liu Shahid M Nimjee Raul G Nogueira Mehdi Abbasi Ramanathan Kadirvel | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 4 | Corrigendum to “Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis” [Cancer Lett. 328 (2) (2012) 212–221]显示文摘 | Angela L. McCleary-Wheeler Gwen A. Lomberk Frank U. Weiss Günter Schneider Muller Fabbri Tara L. Poshusta Nelson J. Dusetti Sandra Baumgart Juan L. Iovanna Volker Ellenrieder Raul Urrutia Martin E. Fernandez-Zapico | 2013 | Cancer Letters2013，，1： | 2 |
| 5 | Cost-sensitive learning based on Bregman divergences 显示文摘 | RAUL S R ROCIO A R ALICIA G C | 2009 | Machine Learning Journal2009，76，： | 1 |
| 6 | Regulation of ammonium ion alvage and enhancement of the storage protein contents of corn,sweet potato,and yam tuber by N-C(carboxymethyl) chitosan application显示文摘 | Godson O Osuji Raul G Guero | 1992 | Agric Food Chem1992，40，5： | 1 |
| 7 | Sun,wind and water flow as energy supply for smallstationary data acquisition platforms显示文摘 | Raul Morais Miguel A Fernandes Samuel G Matos | | 0，，02： | 1 |
| 8 | A ZigBee multi-powered wireless acquisition device for remote sensing applications in precision viticulture显示文摘 | Raul Morais Miguel A Fernandes Samuel G Matos | | 0，，02： | 1 |
| 9 | Sun, wind and water flow as energy supply for small stationary data acquisition platforms显示文摘 | Raul Morais Samuel G Matosb Miguel A Femandesb | 2008 | Computers and electronics in agriculture2008，64，2： | 1 |
| 10 | Modeling track-terrain interaction for transient robotic vehicle maneuvers显示文摘 | JAVIER M S RAUL G L | 2008 | Journal ofTerramechanics2008，45，3： | 1 |
| 11 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 1 |
| 12 | Coordinated and reeonfigurable vehicle dynamics control 显示文摘 | Wang Jun-min Longoria Raul G | 2009 | IEEE Transactions on Control Systems Technology2009，17，3： | 1 |
| 13 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 14 | Chemi cal recycling of carbon fibre composites using alcohols under subcritical and supercritical conditions显示文摘 | RAUL P H JUAN G S CHRISTOPHER D | 2008 | Journal of Super- critical Fluids2008，46，： | 1 |
| 15 | Influ- ence of waterlogging on some anti-oxidative enzymatic activities of two barley genotypes differing in anoxia tolerance显示文摘 | Rubio G Raul S Laavado Rendina A | 1995 | Wetlands1995，15，4： | 1 |
| 16 | On the application of static equilibrium bay formulations to natural and man made beaches显示文摘 | Mauricio G Raul M | | 0，，： | 1 |
| 17 | Traumatic posterior urethral injury and early primary endoscopic realignment: evaluation of long-term follow-up显示文摘 | Brett R Jepson John A Boullier Robert G Moore Raul O Parra | 1999 | Urology1999，，6： | 1 |
| 18 | An ice test for the diagnosis of myasthenia gravis显示文摘 | Karl C Golnik Raul Pena Andrew G Lee Eric R Eggenberger | 1999 | Ophthalmology1999，，7： | 1 |
| 19 | Treating acute large vessel occlusion stroke:to bridge or not to bridge?显示文摘Hot debates exist regarding whether patients who had an acute large vessel occlusion stroke(LVOS)can skip tissue plasminogen activator(tPA)and go directly to thrombectomy in comprehensive stroke centres.Three head-to-head randomised clinical trials(RCTs)of direct endovascular treatment(dEVT)versus bridge therapy(BT)with intravenous alteplase have been recently completed in the Asian population.The DIRECT-MT(Direct Intraarterial Thrombectomy in Order to Revascularize Acute Ischemic Stroke Patients with Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals:a Multicenter Randomized Clinical Trial)Study randomly enrolled 656 patients who had an acute ischaemic stroke with anterior circulation LVOS across 41 large teaching hospitals in China to receive BT or dEVT within 4.5 hours after symptom onset. | Yunyun Xiong Yuesong Pan Raul G Nogueira Zeguang Ren Tudor G Jovin Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
| 20 | Synthesis and structure of new heterocy- clic derivatives of curcumln显示文摘 | M Concepcion Lozada Raul G Endclueez Carlos E Lobato | 2005 | Heterocyclic2005，65，1： | 1 |
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