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| 1 | 免疫鸡产生IgY抗体的技术显示文摘IgY技术正在成为生物技术领域和医药研究中的新热点 ,并且越来越得到国内同仁的重视。因为卵黄抗体 (IgY)化学性质稳定 ,产量高、成本低 ,以及动物种系距离的优势 ,更适于生产特异性抗体 ,具有开发功能性食品和新药的潜能。作为系列介绍的第二部分 ,本文详细介绍和探讨免疫鸡产生IgY抗体技术的主要技术环节和实践应用方面的具体信息 ,包括动物饲养 ,对鸡的免疫 ,抗体特性 ,IgY提取技术 ,鸡单克隆抗体的制备等方面。 | 张小莺 郑礼 Rüdiger Schade Horacio Raul Terzolo Hanibal Pablo Chacana Joanna Porankiewicz-Asplund | 2004 | 中国药理学通报2004，20，10： | 19 |
| 2 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 3 | Cost-sensitive learning based on Bregman divergences 显示文摘 | RAUL S R ROCIO A R ALICIA G C | 2009 | Machine Learning Journal2009，76，： | 1 |
| 4 | Nickel alloys for corrosive environments显示文摘 | RAUL B R CROOK P | 2000 | Advanced Materials and Processes2000，157，2： | 1 |
| 5 | Ethylene polymerization using dealuminated ZSM-2 zeolite nanocrystals as an active metallocene catalyst support显示文摘 | Cristian C Raul Q Rene R | 2008 | Applied catalysis A: General2008，347，2： | 1 |
| 6 | Identification of microorganisms by PCR amplification and sequencing of a universal amplified ribosomal region present in both prokaryotes and eukaryotes 显示文摘 | Raul R Encarna V Luis ZJ | 2004 | J Microbiol Methods2004，56，3： | 1 |
| 7 | Staphylococ-cus aureus invasion of bovine mammary epithelial cells显示文摘 | RAUL A A KARL R M EDUARDO C | | 0，，6： | 1 |
| 8 | Traumatic posterior urethral injury and early primary endoscopic realignment: evaluation of long-term follow-up显示文摘 | Brett R Jepson John A Boullier Robert G Moore Raul O Parra | 1999 | Urology1999，，6： | 1 |
| 9 | An ice test for the diagnosis of myasthenia gravis显示文摘 | Karl C Golnik Raul Pena Andrew G Lee Eric R Eggenberger | 1999 | Ophthalmology1999，，7： | 1 |
| 10 | Mode of action of laetocin 705, a two-component bacteriocin from LactobaciUus casei CRL705显示文摘 | Patrieia C Raul R Graeiela V | 2003 | Int J Foods Microbiol2003，85，2： | 1 |
| 11 | Adsorption of fluoride from water solution on bone char显示文摘 | NAHUM A M C ROBERTO L R RAUL O P | 2007 | Industrial Engineering Chemistry Research2007，46，26： | 1 |
| 12 | Numerical calculation of flutter derivatives via indicial functions显示文摘 | Brar P S Raul R Scanlan R H | 1996 | Journal of Fluids and Structures1996，10，： | 1 |
| 13 | Genetic approaches to studying norepinephrine function:knockout of the mouse norepinephrine transporter gene显示文摘 | Wang YM Xu F Raul R | 1999 | Biol Psychiatry1999，9，46： | 1 |
| 14 | Finite element modelling of human head injuries caused by a fall显示文摘 | Jean-Sébastien Raul Daniel Baumgartner Rémy Willinger Bertrand Ludes | 2006 | International Journal of Legal Medicine2006，，4： | 1 |
| 15 | Scientific and technological fundamentals for the development of the controlled short-circuiting MIG/MAG welding process: a review of the literature显示文摘 | SILVA R H G DUTRA J C RAUL G J | 2009 | 23 (2): 141-1492009，23，2： | 1 |
| 16 | Finite-element models of the human head and their applications in forensic practice显示文摘 | Raul J S Deck C Willinger R | | 0，，05： | 1 |
| 17 | Paclitaxel as sociated with cholesterol-rieh nanoemulsions promotes atheroselerosis regression in the rabbit显示文摘 | Raul C Maranhao Elaine R Tavares | 2008 | Atheroscle rosis2008，197，： | 1 |
| 18 | Intestinal adaptation to nutritional stress显示文摘 | Raul F Schleiffer R | 1996 | Proc Nutr Soc1996，55，： | 1 |
| 19 | Finite element modelling of paediatric lead impact: Global validation against experimental data 显示文摘 | Roth S Raul J S Willinger R | 2010 | Computer Method and Programs in Biomedicine2010，99，： | 1 |
| 20 | The influence of impurities on crystallization kinetics-a case studyon ammonium sulfate 显示文摘 | Rauls M Bartosch K Kind M Kuch S Lacmann R Mersmann A | 2000 | Journal of Crystal Growth2000，213，1： | 1 |
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