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| 1 | Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa显示文摘Autophagy is invoIved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged organelles.Cryptorchidism is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in ejaculates.The aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid patients.Semen samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron microscopy.Autophagy protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm cells.LC3 was also detected in the midpiece of cryptorchid sperm tail.Autophagy substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid ones.Transmission electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid samples.Partly degraded mitochondria were frequently discerned in autophagic vacuoles.In conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to control.Our work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological conditions.Thus,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men. | Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 2 | Predictive, structurebased model of amino acid recognition by nonribosomal peptide synthetase adenylation domains 显示文摘 | Challis G L Ravel J Townsend C A | 2000 | Chem Biol2000，7，： | 1 |
| 3 | Coeliehelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase显示文摘 | Challis G L Ravel J | 2000 | FEMS Microbiol Lett2000，187，2： | 1 |
| 4 | Preparation and microwave characterization of spherical and monodisperse CoNi particles显示文摘 | RAVEL F ACHER P | 1994 | Appl Phys1994，，10： | 1 |
| 5 | Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains 显示文摘 | Challis G L Ravel J Townsend C A | 2000 | Chem Biol2000，7，： | 1 |
| 6 | Intravascular ultrasound findings in the multicenter, randomized, double-blind RAVEL (RAndomized study with the sirolimus-eluting VElocity balloon-expandable stent in the treatment of patients with de novo native coronary artery Lesions) trial显示文摘 | Serruys PW Degertekin M Tanabe K Abizaid A Sousa JE Colombo A Guagliumi G Wijns W Lindeboom WK Ligthart J de Feyter PJ Morice MC RAVEL Study Group | 2002 | Circulation2002，106，7： | 1 |
| 7 | Preparation and microwave characterization of spherical and monodisperse Co-Ni particles 显示文摘 | Viau G Ravel F Acher O Fievet-Vincent F Fievet F | 1995 | Journal of Magnetism and Magnetic Materials1995，140，144： | 1 |
| 8 | Preparation and microwave characterization of spherical and monodisperse Co-Ni particles显示文摘 | VIAU G RAVEL F FIEVET-VINCENT F | 1995 | J Magn Magn Mater1995，，1： | 1 |
| 9 | Preparation and microwave characterization of spherical and monodisperse Co-Ni particles 显示文摘 | VIAU G RAVEL F FIEVER VINCENT F | 1995 | Magnetism and Magnetic Materials1995，，： | 1 |
| 10 | Structural Specificity of Some Amino Acid Antagonists 显示文摘 | Edelson J Skinner C G Ravel J M | 1959 | J Am Chem Soc1959，81，19： | 1 |
| 11 | Analysis of phylogenetic relationships in the triticeae tribe using RFLPs显示文摘 | Monte JV Charmet G Ravel C | 1993 | TAG1993，86，： | 1 |
| 12 | Preparation and microwave characterization of spherical and monodisperse Co20Ni80 particles显示文摘 | VIAU G RAVEL F ACHER O | 1994 | J Appl Phys1994，76，10： | 1 |
| 13 | Immune assessments in developmental and juvenile toxicology: practical considerations for the regula- tory safety testing of pharmaceuticals 显示文摘 | Barrow PC Ravel G | 2005 | Regul Toxicol Pharma- col2005，43，1： | 1 |
| 14 | 显示文摘 | Ravel F Archer O | 1995 | J M M M1995，377，： | 1 |
| 15 | Preparation and microwave characterization of spherical and monodisperse CoNi particles显示文摘 | Viau G Ravel F Acher P | 1994 | J Appl Phys1994，，10： | 1 |
| 16 | Genotype×envimnnmnt interactions in a core collection of French perennial ryegrass populations 显示文摘 | Channet G Balfourier F Ravel C Benis J B | 1993 | Theor Appl Genet1993，86，： | 1 |
| 17 | Popliteal lymph node assay: facts and perspectives显示文摘 | Ravel G Descotes J | 2005 | J Appl Toxicol2005，25，6： | 1 |
| 18 | Autoimmunity, environmental exposure and vaccination: is there a link 显示文摘 | Ravel G Christ M Horand F | 2004 | Toxicology2004，196，3： | 1 |
| 19 | PCR identification of Trypanosoma lewisi,a common parasite of laboratory rats显示文摘 | Desquesnes M Ravel S Cuny G | 2002 | Kinetoplastid Bio Dis2002，1，： | 1 |
| 20 | Engineering p- hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation 显示文摘 | GUNSIOR M RAVEL J CHALLIS G L | 2004 | Biochemistry2004，43，3： | 1 |
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