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| 1 | Role of Akt signaling in resistance to DNA-targeted therapy显示文摘The Akt signal transduction pathway controls most hallmarks of cancer. Activation of the Akt cascade promotes a malignant phenotype and is also widely implicated in drug resistance. Therefore, the modulation of Akt activity is regarded as an attractive strategy to enhance the efficacy of cancer therapy and irradiation. This pathway consists of phosphatidylinositol 3 kinase(PI3K), mammalian target of rapamycin, and the transforming serine-threonine kinase Akt protein isoforms, also known as protein kinase B. DNA-targeted agents, such as platinum agents, taxanes, and antimetabolites, as well as radiation have had a significant impact on cancer treatment by affecting DNA replication, which is aberrantly activated in malignancies. However, the caveat is that they may also trigger the activation of repairing mechanisms, such as upstream and downstream cascade of Akt survival pathway. Thus, each target can theoretically be inhibited in view of improving the potency of conventional treatment. Akt inhibitors, e.g., MK-2206 and perifosine, or PI3K modulators, e.g., LY294002 and Wortmannin, have shown some promising results in favor of sensitizing the cancer cells to the therapy in vitro and in vivo, which have provided the rationale for incorporation of these novel agents into multimodality treatment of different malignancies. Nevertheless, despite the acceptable safety profile of some of these agents in the clinical studies, with regard to the efficacy, the results are still too preliminary. Hence, we need to wait for the upcoming data from the ongoing trials before utilizing them into the standard care of cancer patients. | Abolfazl Avan Ravi Narayan Elisa Giovannetti Godefridus J Peters | 2016 | World Journal of Clinical Oncology2016，7，5： | 12 |
| 2 | 小麦品种川麦107对条锈病成株抗性的QTL定位显示文摘【目的】发掘川麦107中的条锈病成株抗性基因及与其紧密连锁的分子标记,为小麦持久抗性育种提供基因和分子标记辅助选择工具。【方法】在墨西哥国际玉米小麦改良中心(CIMMYT)Toluca试验站、中国成都和雅安3个环境下,对川麦107/Avocet-YrA组合的F5代重组自交系(recombinant inbred line,RIL)群体进行了小麦条锈病成株抗性鉴定,在此基础上利用SSR标记和复合区间作图法对成株抗性基因进行定位。【结果】在1B染色体长臂远端的Xcwem32和Xgwm818位点之间(连锁距离3.9cM)检测到1个主效QTL,暂定名为QYr.saas-1BL。该主效QTL在3个试验环境下分别解释19.3%、16.9%和27.4%的表型变异。【结论】QYr.saas-1BL是川麦107中对条锈病有持久抗性的成株抗性QTL。 | 朱华忠 王忠伟 伍玲 Ravi P Singh J Huerta-Espino 何中虎 胡嘉 陈放 夏先春 | 2010 | 中国农业科学2010，43，4： | 4 |
| 3 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 4 | Quantitative essential amino acid requirements for growth of catla,Catla catla(Hamilton)显示文摘 | Ravi J Devaraj K V | 1991 | Aquaculture1991，96，： | 1 |
| 5 | CD8 + Tregs in lupus,auto-immunity ,and beyond显示文摘 | Ravi K Dinesh Brian J | 2010 | Autoimmun Rev2010，9，8： | 1 |
| 6 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 7 | Role-Based Access Control Models显示文摘 | Ravi S Sandhu Edward J Coyne Hal L Feinstein | 1996 | IEEE Computer1996，29，2： | 1 |
| 8 | Grain refinement in AZ91 magnesium alloy during thermomechanical processing显示文摘 | RAVI KUMAR N V BLANDIN J J DESRAYAUD C | 2003 | Materials and Engineering A2003，359，： | 1 |
| 9 | SO2scrubbing technologies:A review显示文摘 | Ravi K S Wojciech J Carl S | 2001 | Environmental Progress2001，20，4： | 1 |
| 10 | A biologically inspired micro-vehicle capable of aerial and terrestrial locomotion 显示文摘 | Richard J Bachmann Frank J Boria Ravi Vaidyanathan | 2009 | Mechanism and Machine Theory (S0094-114X)2009，44，3： | 1 |
| 11 | Heuristic and special case algorithms for dispersion problems显示文摘 | Ravi S S Rosenkrantz D J Tayi G K | 1994 | Operations Research1994，42，2： | 1 |
| 12 | Role-Based Access Control Models显示文摘 | Sandhu Ravi Coyne Edward J Feinstein Hal L | 1996 | IEEE Computer1996，29，2： | 1 |
| 13 | An analysis of elasto-plastic sliding apherical asperity interaction显示文摘 | ROBERT L J RAVI S D HASNAIN M MANOJ M | 2007 | Wear2007，262，12： | 1 |
| 14 | Role-based access control models显示文摘 | Ravi S Sandhu Edward J Coyne Hal L Feinstein | 1996 | Computer1996，29，2： | 1 |
| 15 | An unusual, muddy, epeiric carbonate reservoir: The Lower Muschelkalk(Middle Triassic) of the Netherlands显示文摘 | Ravi B Thomas A Koos J C P P | 2006 | AAPG Bulletin2006，90，1： | 1 |
| 16 | Role-based access control models显示文摘 | Edward J Coyne Hal L Feinstein | 1996 | IEEE Computer1996，29，2： | 1 |
| 17 | Fuzzy linear fractional goal programming applied to refinery operations planning显示文摘 | Ravi V Reddy P J | 1998 | Fuzzy Sets and Systems1998，96，： | 1 |
| 18 | Di-amine functionalized cubic mesoporous silica for ibu- profen controlled delivery显示文摘 | SIVAGURU J SELVARAJ M RAVI S | 2015 | J Nanosci Nanotech- no2015，15，7： | 1 |
| 19 | Role based access control models显示文摘 | Ravi Sandhu Edward J Coyne | 1996 | IEEE Computer1996，29，2： | 1 |
| 20 | Role-based access control models显示文摘 | Edward J Coyne Hal L Feinstein | 1996 | IEEE Computer1996，29，2： | 1 |
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