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您的检索式：作者名="Raymond AH"
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| 1 | Effect of Graphene Nanoribbons (TexasPEG) on locomotor function recovery in a rat model of lumbar spinal cord transection显示文摘A sharply transected spinal cord has been shown to be fused under the accelerating influence of membrane fusogens such as polyethylene glycol(PEG)(GEMINI protocol). Previous work provided evidence that this is in fact possible. Other fusogens might improve current results. In this study, we aimed to assess the effects of PEGylated graphene nanoribons(PEG-GNR, and called 'Texas PEG' when prepared as 1 wt% dispersion in PEG600) versus placebo(saline) on locomotor function recovery and cellular level in a rat model of spinal cord transection at lumbar segment 1(L_1) level. In vivo and in vitro experiments(n = 10 per experiment) were designed. In the in vivo experiment, all rats were submitted to full spinal cord transection at L_1 level. Five weeks later, behavioral assessment was performed using the Basso Beattie Bresnahan(BBB) locomotor rating scale. Immunohistochemical staining with neuron marker neurofilament 200(NF200) antibody and astrocytic scar marker glial fibrillary acidic protein(GFAP) was also performed in the injured spinal cord. In the in vitro experiment, the effects of Texas PEG application for 72 hours on the neurite outgrowth of SH-SY5 Y cells were observed under the inverted microscope. Results of both in vivo and in vitro experiments suggest that Texas PEG reduces the formation of glial scars, promotes the regeneration of neurites, and thereby contributes to the recovery of locomotor function of a rat model of spinal cord transfection. | C-Yoon Kim William K. A. Sikkema Jin Kim Jeong Ah Kim James Walter Raymond Dieter Hyung-Min Chung Andrea Mana James M. Tour Sergio Canavero | 2018 | Neural Regeneration Research2018，13，8： | 2 |
| 2 | Synthesis, morphology and optical properties of tetrahedral oligo (phenylenevinylene) materials 显示文摘 | Wang S Oldham WJ Raymond AH | 2000 | J Am Chem Soc2000，122，24： | 1 |
| 3 | Wettability of Nonwoven Fabrics显示文摘 | Sarmadi A Majid Kwon Young Ah Young Raymond A | 1993 | Ind Eng Chem Res1993，32，： | 1 |
| 4 | Synthesis, mor- phology and opticalproperties of tetrahedral oligo(phenylenevinylene) materials显示文摘 | Wang S Oldham WJ Raymond AH etal | 2000 | J Am Chem Soc2000，122，24： | 1 |
| 5 | Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing显示文摘Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical studies.Although MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated. | Shang Jiunn Chuah Chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen Wong Asher Ah Tong Lim Sai Kiang Lim Wei Seong Toh | 2022 | Genes & Diseases2022，9，4： | 0 |
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