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| 1 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 2 | A genetic link?age map of microsatellites in the domestic cat (Felis catus)显示文摘 | Menotti - Raymond M David V A Lyons LA | 1999 | Ge?nomics1999，57，1： | 1 |
| 3 | Time, tact, talent, and trust: essential ingredients of effective academic- community partnerships显示文摘 | Plowfield LA Wheeler EC Raymond J E | 2005 | Nursing Education Perspectives2005，26，4： | 1 |
| 4 | Regulation of ligand-gated ion channels by protein phosphorylafon 显示文摘 | Swope-SL Moss-SI Raymond LA | 1999 | Adv-Second-Messenger- Phosphoprotein-Res1999，33，： | 1 |
| 5 | Fibrovascular ingrowth at sclerotomy sites in vitretomaized diabetic eyes with recurrent vitreous hemorrhage: ultrasound biomicroscopy findings 显示文摘 | Hershberger VS Augsburger J J Hutchins RK Raymond LA Krug S | 2004 | Ophthalmology2004，111，6： | 1 |
| 6 | Extrasynaptic NMDA receptor involvement in central nervous system disorders显示文摘 | Parsons MP Raymond LA | 2014 | Neu- ron2014，82，2： | 1 |
| 7 | Large suprasellar aneurysms imitating pituitary tumour显示文摘 | Raymond LA Tew J | 1978 | J Neurol Neurosurg Psychiatry1978，41，1： | 1 |
| 8 | Evidence of lasting dysregulation of neuroendocrine and HPA axis function following global cerebral is- chemia in male rats and the effect of Antalarmin on plasma corticosterone level显示文摘 | de la TrembIaye PB Raymond J Milot MR | 2014 | Horm Behav2014，65，3： | 1 |
| 9 | Etanercept for refractory ocular sarcoidosis: results of a double-blind randomized trial 显示文摘 | Baughman RP Lower EE Bradley DA Raymond LA Kaufman A | 2005 | Chest2005，128，2： | 1 |
| 10 | Regulation of ligand-gated ion channels by protein phosphorylation显示文摘 | Swope SL Moss SI Raymond LA | 1999 | Adv Second Messenger Phosphoprotein Res1999，33，： | 1 |
| 11 | Mechanisms underlying NM-DA receptor synaptic/extrasynaptic distribution and func- tion显示文摘 | Gladding CM Raymond LA | 2011 | Mol Cell Neurosci2011，48，4： | 1 |
| 12 | Cardiovascular disease in peritoneal dialysis patients显示文摘 | Norbest LA Raymond C | 1996 | Kidney Int1996，50，51： | 1 |
| 13 | The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms显示文摘 | Bryan G. Fry Kim Roelants Donald E. Champagne Holger Scheib Joel D.A. Tyndall Glenn F. King Timo J. Nevalainen Janette A. Norman Richard J. Lewis Raymond S. Norton Camila Renjifo Ricardo C. Rodríguez de la Vega | 2009 | Annual Review of Genomics and Human Genetics2009，，： | 1 |
| 14 | Subtype-dependence of NMDA receptor channel open probability显示文摘 | Luo T Raymond LA | 1999 | J Neurosci1999，19，16： | 1 |
| 15 | Evidence of lasting dysregulation of neuroendocrine and HPA axis function following global cerebral ischemia in male rats and the effect of Antalarmin on plasma corticosterone level显示文摘 | de la Tremblaye PB Raymond J Milot MR | 2014 | Horm Behav2014，65，3： | 1 |
| 16 | HT-SuperSAGE of the gut tissue of a Vip3Aa-resistant Heliothis virescens (Lepidoptera: Noctuidae) strain provides insights into the basis of resistance显示文摘Multitoxin Bt-crops expressing insecticidal toxins with different modes of action, for example, Cry and Vip, are expected to improve resistance management in target pests. While Cry1A resistance has been relatively well characterized in some insect species, this is not the case for Vip3A, for which no mechanism of resistance has yet been identified. Here we applied HT-SuperSAGE to analyze the transcriptome of the gut tissue of tobacco budworm Heliothis virescens (F.) laboratory-selected for Vip3Aa resistance. From a total of 1 324 252 sequence reads, 5 895 126-bp tags were obtained representing 17 751 nonsingleton unique transcripts (UniTags) from genetically similar Vip3Aa-resistant (Vip- Sel) and susceptible control (Vip-Unsel) strains. Differential expression was significant (≥2.5 fold or ≤0.4;P < 0.05) for 1989 sequences (11.2% of total UniTags), where 420 represented overexpressed (OE) and 1569 underexpressed (UE) genes in Vip-Sel. BLASTN searches mapped 419 UniTags to H. virescens sequence contigs, of which, 416 (106 OE and 310 UE) were unambiguously annotated to proteins in NCBI nonredundant protein databases. Gene Ontology distributed 345 of annotated UniTags in 14 functional categories with metabolism (including serine-type hydrolases) and translation/ribosome biogenesis being the most prevalent. A UniTag homologous to a particular member of the REsponse to PAThogen (REPAT) family was found among most overexpressed, while UniTags related to the putative Vip3Aa-binding ribosomal protein S2 (RpS2) were underexpressed. qRT-PCR of a subset of UniTags validated the HT-SuperSAGE data. This study is the first providing lepidopteran gut transcriptome associated with Vip3Aa resistance and a foundation for future attempts to elucidate the resistance mechanism. | Camilo Ayra-Pardo Maria E. Ochagavia Ben Raymond Asim Gulzar Lianet Rodriguez-Cabrera Claudia Rodriguez de la Noval Ivis Moran Bertot Ryohei Terauchi Kentaro Yoshida Hideo Matsumura Pilar Tellez Rodriguez Daily Hernandez Hemandez Orlando Borras-Hidalgo Denis J. Wright | 2019 | Insect Science2019，26，3： | 0 |
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