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| 1 | Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4–infected Children显示文摘 | Olfat G. Shaker Yasser H. Nassar Zeinab A. Nour Mona El Raziky | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，2： | 3 |
| 2 | Serum autoantibodies positivity prevalence in patients with chronic HCV and impact on pegylated interferon and ribavirin treatment response显示文摘 | Marwa Khairy Maissa El‐Raziky Wafaa El‐Akel Mohamed S. Abdelbary Hany Khatab Badawy El‐Kholy Gamal Esmat Mahassen Mabrouk | 2013 | Liver Int2013，，10： | 2 |
| 3 | Coinfection with hepatitis C virus and schistosomiasis:Fibrosis and treatment response显示文摘AIM:To assess whether schistosomiasis coinfection with chronic hepatitis C virus (HCV) influences hepatic fibrosis and pegylated-interferon/ribavirin (PEG-IFN/ RIB) therapy response. METHODS:This study was designed as a retrospective analysis of 3596 chronic HCV patients enrolled in the Egyptian National Program for HCV treatment with PEG-IFN/RIB. All patients underwent liver biopsy and anti-schistosomal antibodies testing prior to HCV treatment. The serology results were used to categorize the patients into group A (positive schistosomal serology) or group B (negative schistosomal serology). Patients in group A were given oral antischistosomal treatment(praziquantel, single dose) at four weeks prior to PEG-IFN/RIB. All patients received a 48-wk course of PEG-IFN (PEG-IFNα2a or PEG-IFNα2b)/RIB therapy. Clinical and laboratory follow-up examinations were carried out for 24 wk after cessation of therapy (to week 72). Correlations of positive schistosomal serology with fibrosis and treatment response were assessed by multiple regression analysis. RESULTS:Schistosomal antibody was positive in 27.3% of patients (15.9% females and 84.1% males). The patients in group A were older (P = 0.008) and had a higher proportion of males (P = 0.002) than the patients in group B. There was no significant association between fibrosis stage and positive schistosomal serology (P = 0.703). Early virological response was achieved in significantly more patients in group B than in group A (89.4% vs 86.5%, P = 0.015). However, significantly more patients in group A experienced breakthrough at week 24 than patients in group B (36.3% vs 32.3%, P = 0.024). End of treatment response was achieved in more patients in group B than in group A (62.0% vs 59.1%) but the difference did not reach statistical significance (P = 0.108). Sustained virological response occurred in significantly more patients in group B than in group A (37.6% vs 27.7%, P = 0.000). Multivariate logistic regression analysis of patient data at treatment weeks 48 and 72 showed that positive schistosomal serology was associated with failure of response to treatment at week 48 (OR = 1.3, P = 0.02) and at week 72 (OR = 1.7, P < 0.01). CONCLUSION:Positive schistosomal serology has no effect on fibrosis staging but is significantly associated with failure of response to HCV treatment despite antischistosomal therapy. | Mahasen Abdel-Rahman Mohammad El-Sayed Maissa El Raziky Aisha Elsharkawy Wafaa El-Akel Hossam Ghoneim Hany Khattab Gamal Esmat | 2013 | World Journal of Gastroenterology2013，19，17： | 1 |
| 4 | Osteopontin gene polymorphisms as predictors for the efficacy of interferon therapy in chronic hepatitis C Egyptian patients with genotype 4显示文摘 | Olfat Shaker Amal El‐Shehaby Salwa Fayez Amr Zahra Samar Marzouk Maissa El Raziky | 2013 | Cell Biochem Funct2013，，7： | 1 |
| 5 | Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4–infected Children显示文摘 | Olfat G. Shaker Yasser H. Nassar Zeinab A. Nour Mona El Raziky | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，2： | 1 |
| 6 | Acute hemolytic anemia asan initial presentation of Wilson disease in children显示文摘 | El Raziky MS Ali A El Shahawy A | 2014 | J Pediatr Hema-tol Oncol2014，36，3： | 1 |
| 7 | Acute hemo-lytic anemia as an initial presentation of Wilson disease inchildren 显示文摘 | El Raziky MS Ali A El Shahawy A | 2014 | J Pediatr Hematol Oncol2014，36，3： | 1 |
| 8 | Impact of vitamin D supplementation on sustained virological response in chronic hepa- titis C genotype 4 patients treated by pegylated interferon/ribavirin 显示文摘 | Esmat G E1 Raziky M Elsharkawy A | 2015 | J Interferon Cytokine Res2015，35，1： | 1 |
| 9 | Human leukocyte an- tigen class II 'alleles ( DQBI and DRBI ) as predictors for response to interferon therapy in HCV genotype 4 显示文摘 | Shaker O Bassiony H El Raziky M | 2013 | Mediators lnflamm2013，2013，39： | 1 |
| 10 | Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study显示文摘AIM:To assess co-stimulatory and co-inhibitory markers of dendritic cells(DCs)in hepatitis C virus(HCV)infected subjects with and without uremia.METHODS:Three subject groups were included in the study:group 1 involved 50 control subjects,group2 involved 50 patients with chronic HCV infection and group 3 involved 50 HCV uremic subjects undergoing hemodialysis.CD83,CD86 and CD40 as co-stimulatory markers and PD-L1 as a co-inhibitory marker were assessed in peripheral blood mononuclear cells by realtime polymerase chain reaction.Interleukin-10(IL-10)and hyaluronic acid(HA)levels were also assessed.All findings were correlated with disease activity,viral load and fibrogenesis.RESULTS:There was a significant decrease in costimulatory markers;CD83,CD86 and CD40 in groups2 and 3 vs the control group.Co-stimulatory markers were significantly higher in group 3 vs group 2.There was a significant elevation in PD-L1 in both HCV groups vs the control group.PD-L1 was significantly lower in group 3 vs group 2.There was a significant elevation in IL-10 and HA levels in groups 2 and 3,where IL-10was higher in group 3 and HA was lower in group 3 vs group 2.HA level was significantly correlated with disease activity and fibrosis grade in group 2.IL-10 was significantly correlated with fibrosis grade in group 2.There were significant negative correlations between co-stimulatory markers and viral load in groups 2 and3,except CD83 in dialysis patients.There was a significant positive correlation between PD-L1 and viral load in both HCV groups.CONCLUSION:A significant decrease in DC co-stimulatory markers and a significant increase in a DC coinhibitory marker were observed in HCV subjects and to a lesser extent in dialysis patients. | Hanan Fouad Maissa Saeed El Raziky Rasha Ahmed Abdel Aziz Dina Sabry Ghada Mahmoud Abdel Aziz Manal Ewais Ahmed Reda Sayed | 2013 | World Journal of Gastroenterology2013，19，43： | 0 |
| 11 | Regulatory and activated effector T cells in chronic hepatitis C virus: Relation to autoimmunity显示文摘AIM To investigate how Tregs are regulated in chronic hepatitis C virus(HCV) patients via assessment of Tregs markers(granzyme 2, CD69 and FoxP3), Teffs markers [TNFRSF4(OX40), INFG] and CD4, CD25 genes. METHODS A prospective study was conducted on 120 subjects divided into 4 groups: Group Ⅰ(n = 30) treatment na?ve chronic HCV patients; Group Ⅱ(n = 30) chronic HCV treated with Peg/Riba; Group Ⅲ(n = 30) chronic HCV associated with non-organ specific autoantibody and Group Ⅳ(n = 30) healthy persons as a control group. Tregs and Teffs markers were assessed in peripheral blood mononuclear cells by quantitative real time reverse transcriptase-polymerase chain reaction. RESULTS Chronic HCV patients exhibited significant higher levels of both Teffs and Tregs in comparison to healthy control group. Tregs markers were significantly decreased in Peg/Riba treated HCV patients in comparison to treatment na?ve HCV group. In HCV patients with antinuclear antibody(ANA) +ve, Tregs markers were significantly decreased in comparison to all other studied groups. Teffs markers were significantly elevated in all HCV groups in comparison to control and in HCV group with ANA +ve in comparison to treatment na?ve HCV group.CONCLUSION Elevated Tregs cells in chronic HCV patients dampen both CD4^+ and CD8^+ autologous T cell immune response. Interferon-α and ribavirin therapy suppress proliferation of Tregs. More significant suppression of Tregs was observed in HCV patients with autoantibodies favoring pathological autoimmune response. | Hanan Fouad Maissa El Raziky Eman Medhat Hassan Ghada Mahmoud Abdel Aziz Samar K Darweesh Ahmed Reda Sayed | 2016 | World Journal of Hepatology2016，8，30： | 0 |
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