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1全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T 2015中国药物依赖性杂志2015,24,6:3
2Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations显示文摘Soldner F Laganière J Cheng A W Hockemeyer D Gao Q Alagappan 1 Khurana V Golbe L I 0,,02:1
3Report on the second Latin American consensus conference for flow cytometric immunophenotyping of hematological malignancies显示文摘Ruiz-Arguelles A Rivadeneyra-Espinoza L Duque RE 0,,:1
4Percutaneous verlebro-- plasty, long-term clinic and radiological outcome显示文摘Perez-- Higueras A Alvarez L Rossi RE 2002Neuroradiology2002,44,11:1
5MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre 2010Clinical Chemistry2010,,:1
6Urethral replacement using cellseeded tubularized col lagen matrices显示文摘De Fi l ippo RE Yoo JJ Atala A 2002J Urol2002,168,:1
7A guide to de- veloping a culturally competent organization显示文摘Purnell L Davidhizar RE Giger JN et a/ 2011J Transcult Nurs2011,22,1:1
8Next-generation mobile satellite networks显示文摘DEL:2002}DEL RE A PIERUCCI L 2002IEEE Communications Magazine2002,40,9:1
9Size and geometry of hepatic radiofrequency lesions显示文摘S Mulier Y Ni Y Miao A Rosière A Khoury G Marchal L Michel 2003European Journal of Surgical Oncology2003,,10:1
10Postmenopausal se-rum sex steroids and risk of hormone receptor positive and negative breast cancer:a nested case-control study 显示文摘Ritte RE Lukanova A Dossus L 2011Cancer PrevRes(Phila)2011,4,10:1
11An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism : the use of fluorocitrate 显示文摘Paulsen RE Contestabile A Villani L 1987Neurochem1987,48,5:1
12Percutaneous vertebroplasty: long - term clinical and radiological outcome 显示文摘Perez-Higueras A Alvarez L Rossi RE 2002Neuroradiology2002,44,11:1
13Does social capital ?To what ex- tent? 显示文摘Re'jean L Nabil A 2002Technological Forecasting & Social Change2002,69,7:1
14Non resorbing osteo-clasts induce migration and osteogenic differentiation of mes-enchymal stem cells显示文摘Kreja L Brenner RE Tautzenberger A 2010J Cell Biochem2010,109,2:1
15Oxidative stress at the vascular wall : mechanisticand pharacologicalaspects 显示文摘ROJAS A FIGUEROA H RE L 2006Arch Med Res2006,37,4:1
16Percutaueous verte- broplasty : leng - term clinical and radiological outcome显示文摘Perez -Higueras A Alvarez L Rossi RE 2002Neurora- diology2002,11,:1
17Immobilized Rh,Ru,Pd and Ni complexes as catalysts in the hydrogenation of cyclohexene显示文摘CAGNOLA E A QUIROGA M E LIPRANDI D A L'ARGENTIRE P C 2004Appl Catal A2004,274,12:1
18Non-resorbing osteoclasts induce migration and osteogenic differentiation of mesenchymal stem cells显示文摘Kreja L Brenner RE Tautzenberger A 0,,02:1
19Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigenchallenged asthmatics显示文摘Crikshank WW Long A Tarpy RE Kornfeld H Carroll MP Teran L 1995Am J Respir Cell Mol Biol1995,13,6:1
20The reduction of the substitutional C content in annealed Si/SiGeC superlattices studied bydark-field electron holography显示文摘Denneulin T Rouvière J L Béché A 0,,:1
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