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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Prevalence of myocardial bridging and correlation with coronary atherosclerosis studied with 64-slice CT coronary angiography显示文摘 | La Grutta L Runza G Lo Re G | | 0，，： | 1 |
| 3 | Prevalence of myoear dial bridging and correlation with coronary atherosclerosis studied with 64-slice CT coronary angiography显示文摘 | La Grutta L Runza G Lo Re G | 2009 | Radiol Med2009，114，7： | 1 |
| 4 | Size and geometry of hepatic radiofrequency lesions显示文摘 | S Mulier Y Ni Y Miao A Rosière A Khoury G Marchal L Michel | 2003 | European Journal of Surgical Oncology2003，，10： | 1 |
| 5 | Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1显示文摘 | Subramanian G Schwarz RE Higgins L | 2004 | Cancer Res2004，64，15： | 1 |
| 6 | Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotypel显示文摘 | Subramanian G Schwarz RE Higgins L | 2004 | Cancer Res2004，64，15： | 1 |
| 7 | Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotypel 显示文摘 | Subramanian G Schwarz RE Higgins L | 2004 | Cancer Res2004，64，15： | 1 |
| 8 | The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain:comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design显示文摘 | Carmichael JA Lawrence MC Graham LD Pilling PA Epa VC Noyce L Lovrecz G Winkler DA Pawlak-Skrzecz A Eaton RE Hannan GN Hill R J | | 0，，23： | 1 |
| 9 | Hybridization between transgenic Brassica napus L. and its wild relatives: Brassica rapa L., Raphanus raphanistrum L., Sinapis arvensis L., and Erucastrum gallicum (Willd.) O.E. Schulz显示文摘 | S. I. Warwick M.-J. Simard A. Légère H. J. Beckie L. Braun B. Zhu P. Mason G. Séguin-Swartz C. N. Stewart | 2003 | Theoretical and Applied Genetics2003，，3： | 1 |
| 10 | K1R/HLA combination associated with the risk of complications in celiac disease显示文摘 | Caggiari L Toffoli G De Re V | 2011 | Int J Biol Markers2011，26，4： | 1 |
| 11 | Production of butanol (a biofuel) from agricultural residues: Part II-use of corn stover and switchgrass hydrolysates 显示文摘 | Qureshi N Saha BC Hector RE Dien B Hughes S Liu S Iten L Bowman MJ Sarath G Cotta MA | 2010 | Biomass Bioenergy2010，34，： | 1 |
| 12 | In te r n a tio n a l c o lla b o ra tio nin m e d ic a l r e s e a r c h in L a tin A m e ric a a n d th eC a r ib b e a n ( 2003-2007 ) 显示文摘 | C h in c h illa -R o d rig u e z Z B e n a v e n t-P e re z M M o y a -A n e g o n F e t a l | 2012 | J o u r n a l o f th e A me r ic a n S o c ie ty fo r In fo rm a tio n S c ie n c e a n dT e c h n o lo g y2012，63，11： | 1 |
| 13 | Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive pbenotype1显示文摘 | Subramanian G Schwarz RE Higgins L | 2004 | Cancer Res2004，64，15： | 1 |
| 14 | Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage Ⅱ and Ⅲ colon cancer: results from NSABP C-07显示文摘 | Kuebler JP Wieand HS O’Connell MJ Smith RE Colangelo LH Yothers G Petrelli NJ Findlay MP Seay TE Atkins JN Zapas JL Goodwin JW Fehrenbacher L Ramanathan RK Conley BA Flynn PJ Soori G Colman LK Levine EA Lanier KS Wolmark N | 2007 | J Clin Oncol2007，25，16： | 1 |
| 15 | Structure Control: Past, Present, and Future 显示文摘 | Housner G W Bergman L A Caughey T K Chassiakos AG Claus R O Skehon RE Soong T T Spencer B F YaoJ T P | 1997 | Journal of Engineering Mechanics1997，123，9： | 1 |
| 16 | Resin-bonded fixed partial dentures and splints in periodontally compromised patients: a 10-year follow-up显示文摘 | Corrente G Vergnano L Re S | 2000 | Int J Pefiodontics Restorative Dent2000，20，6： | 1 |
| 17 | Functional supervised classification with wavelets显示文摘 | Berlinet A Biau G Rouvière L | 2008 | Annales de I''ISUP2008，52，： | 1 |
| 18 | Hybridization between transgenic Brassica napus L. and its wild relatives: Brassica rapa L., Raphanus raphanistrum L., Sinapis arvensis L., and Erucastrum gallicum (Willd.) O.E. Schulz显示文摘 | S. I. Warwick M.-J. Simard A. Légère H. J. Beckie L. Braun B. Zhu P. Mason G. Séguin-Swartz C. N. Stewart | 2003 | Theoretical and Applied Genetics2003，，3： | 1 |
| 19 | p63 expression in laryn- geal squamous cell carcinoma is related to tumor extension, his- tologic grade, lymph node involvement and clinical stage 显示文摘 | Re M Magliulo G Ferrante L | 2013 | J Biol Regul Homeost Agents2013，27，： | 1 |
| 20 | Blunt pelviperineal injuries:an expanded role for the diverting colostomy显示文摘 | Kusminsky RE Shbeeb L Makos G | 1982 | Dis Colon Rectum1982，25，： | 1 |
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