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| 1 | Is cardiac resynchronisation therapy feasible, safe and beneficial in the very elderly?显示文摘ObjectiveTo evaluate 心脏的同一时刻治疗(CRT ) 培植是否与经历 CRT 培植的 symptoms.MethodsConsecutive 病人一起在 octogenarians 和协会可行、安全,从二个英国中心被招募。根据年龄组织的病人:<80 &≥80 年。基线人口分布,复杂并发症和结果在 439 个病人的那些 groups.ResultsA 总数之间被比较在这研究, 26%≥ 是谁被包括;80 年。Octogenarians 更经常与心脏的同一时刻治疗使用高压脉冲来消减心脏相比收到了心脏的再同步治疗心律调整器。从心律调整器的升级在两个组是普通的(16%<80 年对 22%≥80 年, P = NS ) 。合作病态在两个组是同样普通的(全面糖尿病:25% , atrial 纤维性颤动:23% ,高血压:45%) 。更耐心的年龄 ≥80 年有重要的长期的肾疾病(CKD,估计的 glomerular 过滤率 <45 mL/min 每 1.73 m 2,44% 对 22% , P <0.01 ) 。全面复杂并发症率(任何东西) 在两个组是类似的(16% 对 17% , P = NS ) 。两个组表明了征兆的利益。一个年死亡率作为与更年轻的队相比是在 octogenarians 更大的几乎四褶层(13.9% 对 3.7% , P <0.01 ).ConclusionsCRT 看起来安全在尽管有广泛的合作病态老、特别地经常严重 CKD。征兆的改进看起来有意义。增加的策略是 CRT 的潜在的候选人的有 CHF 的老病人的适当鉴定被要求。 | Bartosz Olechowski Rebecca Sands Donah Zachariah Neil P Andrews Richard Balasubramaniam Mark Sopher John Paisey Paul R Kalra | 2015 | Journal of Geriatric Cardiology2015，12，5： | 5 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Pediatric Nd:YAG laser capsulotomy in the operating room: review of 87 cases显示文摘AIM: To report a large series of children having Nd:YAG laser capsulotomy in the operating room using the lateral decubitus position. METHODS: Medical records of children who underwent Nd:YAG laser capsulotomy in the operating room at Ann & Robert H. Lurie Children's Hospital of Chicago between September 2008 and April 2017 were reviewed. Induction of general anesthesia and intubation was performed in the supine position after which the patient was placed in lateral decubitus position. The Nd:YAG laser capsulotomy was performed using a standard protocol. At the completion of the procedure, the patient was turned back into the supine position and extubated. RESULTS: This study included 87 eyes of 60 patients. Patient's age ranged from 1 to 18 y(mean 6.4±4.1 y). In most cases(84/87, 97%), the procedure was performed under general anesthesia. In all cases, good focus on the membrane was achieved, and the procedure was performed successfully. There were no intraoperative ocular or anesthesia-related complications. CONCLUSION: When performing Nd:YAG laser capsulotomy in the operating room, the lateral decubitus position allowsan easy and safe approach without the risk of potentially devastating complications that have been associated with the previously described sitting and prone positions. | Michael Kinori Narasimhan Jagannathan Anne M Langguth Marjorie A Sasso Marilyn B Mets Bahram Rahmani Hawke Yoon Rebecca Mets-Halgrimson Sudhi P Kurup Janice L Zeid | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 4 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 5 | Spectroscopic studies on the interaction between erlotinib hydrochloride and bovine serum albumin 显示文摘 | ATHINA P REBECCA JG RICHARD AF | 2005 | J Agric Food Chem2005，53，1： | 1 |
| 6 | The interplay of language on execu- tive functions in children with ASD 显示文摘 | Maysa A Rebecca L Rhea P | 2013 | Res Autism Spect Disord2013，7，： | 1 |
| 7 | Mass spectrometric survey of interganglionically transported ppeptides in Aplysia 显示文摘 | LI L J TATIANA P M REBECCA W G | 1998 | Peptides1998，19，8： | 1 |
| 8 | Effect of aquaculture on world fish supplies显示文摘 | ROSAMOND L N REBECCA J G JURGENNE H P | 2000 | Nature2000，405，6790： | 1 |
| 9 | N5^+ cation makes explosive debut显示文摘 | Rebecca P | 1999 | Chemical & Engineering News1999，77，1： | 1 |
| 10 | Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proferation显示文摘 | Jonathan AD Prapaporn P Rebecca S | 2007 | Immunl2007，27，： | 1 |
| 11 | Cardiac tissue engineering:cell seeding,cultivation parameters,and tissue construct characterization显示文摘 | Rebecca LC Maria P Maria R | 1999 | Biotechnol Bioeng1999，64，5： | 1 |
| 12 | Predicting progeny variance from parental divergence in hard spring wheat 显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 13 | Does core needle breast biopsy accurately reflect breast pathology 显示文摘 | Joseph P Crowe J Rebecca J el al | 2003 | Surgery2003，134，4： | 1 |
| 14 | The psychosocial impact of macular degeneration显示文摘 | Williams Rebecca A Brody Barbara M P H Thomas Ronald G | 1998 | Archives of Ophthalmology1998，116，4： | 1 |
| 15 | Study of optimal temperature, pH and stability of dragon fruit (Hylocereus polyrhizus) peel for use as potential natural colorant 显示文摘 | Harivaindaran K V Rebecca O P Chandran S | 2008 | Pakistan Journal of Biological Sciences2008，11，18： | 1 |
| 16 | Characterisation of pea cytosolic glutathione reductase expressed in transgenic tobacco显示文摘 | Rebecca G S Gary P C Philip M M | 2000 | Planta2000，211，： | 1 |
| 17 | Polyethylene Glycol-containing Polyurethanes for Biomedical Applications显示文摘 | Siska C Ngoc P L Etienne S Martyn D Alex S Rebecca G Stephen D Mike W Hugh W Simon C | 1998 | Polymer International1998，46，3： | 1 |
| 18 | Three newly isolated plant growth - promoting bacilli facilitate the seedling growth of canola,Brassica campestris显示文摘 | Sibdas G Jon N P Rebecca D L | 2003 | Plant Physiol Biochem2003，41，： | 1 |
| 19 | Structrual coupling of cardiomyocytes and noncardiomyocytes:quantitative comparisons using a novel micropattemed cell pair assay显示文摘 | Dawn M P Rebecca Y K Nima B | | 0，，： | 1 |
| 20 | Escape of methane gas from the seabed along the West Spitsbergen continental margin显示文摘 | Westbrook Graham K. Thatcher Kate E. Rohling Eelco J. Piotrowski Alexander M. P?like Heiko Osborne Anne H. Nisbet Euan G. Minshull Tim A. Lanoisellé Mathias James Rachael H. Hühnerbach Veit Green Darryl Fisher Rebecca E. Crocker Anya J. Chab | 2009 | Geophysical Research Letters2009，，15： | 1 |
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