|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Filtration increases the correlation between water extractable organic carbon and soil microbial activity显示文摘 | REES R M PARKER J P | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 3 | Allergy, parasites, and the hygiene hypothesis显示文摘 | Yazdanbakhsh M Kremsner PG van Ree R | 2002 | Science2002，19，： | 1 |
| 4 | Extended and compact extragalactic radio sources: interpretation and theory 显示文摘 | Blandford R D Rees M J | 1978 | Physica Scripta1978，17，3： | 1 |
| 5 | Critical flow velocities for the growth and dominance of Anabaena circinalis in some turbid freshwater rivers显示文摘 | MITROVIC S M OLIVER R L REES C | 2003 | Freshwater Biology2003，48，： | 1 |
| 6 | The role of crop rotations in determining soil structure and crop growth conditions显示文摘 | BALL B C BINGHAM I REES R M | 2005 | Canadian Journal of Soil Science2005，85，5： | 1 |
| 7 | Allergy, parasites, and the hygiene hypothesis 显示文摘 | Yazdanbakhsh M Kremsner PG van Ree R | 2002 | Science2002，296，5567： | 1 |
| 8 | Short-term N availability in response to dissolved-organic-carbon from poultry manure, alone or in combination with cellulose显示文摘 | Martín-Olmedo P Rees R M | 1999 | Biology and Fertility of Soils1999，29，： | 1 |
| 9 | Long-term studies of vegeta- tion dynamics显示文摘 | Rees M Condit R Crawley M | 2001 | Science2001，293，： | 1 |
| 10 | Allergy,parasites, and the hygiene hypothesis显示文摘 | Yazdanbakhsh M Kremsner PG van Ree R | 2002 | Science2002，296，5567： | 1 |
| 11 | Allergy, parasites, and the hygiene hypothesis 显示文摘 | YAZDANBAKHSH M KREMSNER P G VAN REE R | 2002 | Science2002，296，5567： | 1 |
| 12 | Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 显示文摘 | Esposito M Grusovin MG Rees J Karasoulos D Felice P Alissa R | 2010 | Cochrane Database Syst Rev2010，，3： | 1 |
| 13 | Relationships between biomass nitrogen and nitrogen extracted by other nitrogen availability methods显示文摘 | STOCKDALE E A REES R M | 1994 | Soil Biol Biochem1994，26，： | 1 |
| 14 | Allergy,parasites and the hygiene hypothesis显示文摘 | Yazdanbakhsh M Kremsner PG van Ree R | 2002 | Science2002，296，5567： | 1 |
| 15 | Markers of the hepatic component of the metabolic syndrome as predictors of mortality in renal transplant reeipients显示文摘 | ZELLE D M CORPELEIJN E VAN REE R M | 2010 | Am J Transplant2010，10，： | 1 |
| 16 | Filtration increases the correlation between water extractable organic carbon and soil microbial activity 显示文摘 | REES R M PARKER J P | 2005 | Soil Biology and Biochemistry2005，37，12： | 1 |
| 17 | Wheat yield progress associated with higherstomatal conductance and photosynthetic rate,and cooler canopies显示文摘 | FISCHER R A D REES K D SAYRE Z M | 1998 | Crop Sci1998，38，： | 1 |
| 18 | Associations of like and un- like polysacchm'ides mechanisms and specificity in glucomannans, interacting bacterial polysacchardies and related systems 显示文摘 | Dea I C M Morns E R Rees D A | 1977 | Carbo- hydrate research1977，57，1： | 1 |
| 19 | Determinants and patterns of population growth in water hyacinth显示文摘 | Wilson J R Hoist N Rees M | 2005 | Aquatic Botany2005，81，： | 1 |
| 20 | Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli显示文摘 | Lowman M A Rees P H Benyon R C | 1988 | J Allergy Clin Immunol1988，81，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员