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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Direct decompressive surreal resection in the treatment of spinal cord compression causeb by metastatic cancer:a randomised trial 显示文摘 | Patchell R Tibbs P Regine W | 2005 | Lancet2005，366，20： | 1 |
| 3 | Geochemical and Pb-Sr-Nd isotopic evidence for separate hot depleted and Iceland plume mantle sources for the Paleogene basalts of the Faroe Islands显示文摘 | Holm P M Niels H Regin W | 2001 | Chem Geo2001，178，： | 1 |
| 4 | Geochemical and Pb-Sr-Nd isotopic evidence for separate hot depleted and Iceland plume mantle sources for the Paleogene basalts of the Faroe Islands 显示文摘 | Holm P M Niels H Regin W | 2001 | Chem Geol2001，178，： | 1 |
| 5 | A dose-ranging study of peglated interferon alfa-2b and ribavirin in chronic hepatitis C 显示文摘 | Paul G Regine R P Glauder R | 2000 | J Hepatol2000，32，3： | 1 |
| 6 | Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial显示文摘 | Patchell RA Tibbs P A Regine WF | 1998 | JAMA1998，280，17： | 1 |
| 7 | Postoperative radiotherapy in the treatment of single metastases to the brain:a randomized trial显示文摘 | PATCHELL R A TIBBS P A REGINE W F | | 0，，： | 1 |
| 8 | Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial显示文摘 | PATCHELL R A TIBBS P A REGINE W F | 1998 | JAMA1998，280，17： | 1 |
| 9 | Postoperative radiotherapy in the treatment of single me- tastases to the brain: a randomized trial 显示文摘 | PATCHELL R A TIBBS P A REGINE W F | 1998 | JAMA1998，280，17： | 1 |
| 10 | A survey of antennal responses by five species of coniferophagous bark beetles(Coleoptera:Scolytidae) to bark volatile of six species of angiosperm trees显示文摘 | Dezene P W Huber Regine Gries | 2000 | Chemoecology2000，10，： | 1 |
| 11 | A survey of antennal responses by five species of coniferophagous bark beetles (Coleoptera:Scolytidae) to bark volatile of six species of angiosperm trees显示文摘 | Dezene P W Regine G Borden J H | 2000 | Chemoecology2000，10，： | 1 |
| 12 | Postopreative radiotherapy in the treatment of single metastasis to the brain:a randomized trial显示文摘 | Patchell R A Tibbs P A regine W F | | 0，，17： | 1 |
| 13 | The challenge of valvular heart disease : when is it time to operate 显示文摘 | Joel P Regineli Brian Griffin | 2004 | Cleveland Clinic Journal of Medicine2004，，6： | 1 |
| 14 | Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial显示文摘 | Patchell R A Tibbs P A Regine W F | 1998 | JAMA1998，280，14： | 1 |
| 15 | Local tumor control in rhabdomyosarcoma following low-dose irradiation:comparison of group II and select group III patients显示文摘 | Regine WF Fontanesi J Kumar P | 1995 | Int J Radiat Oncol Biol Phys1995，31，3： | 1 |
| 16 | Bird pollination in South African Salvia species显示文摘 | Wester P Regine C B | 2006 | Flora - Morphology Distribution Functional Ecology of Plants2006，201，5： | 1 |
| 17 | Distribution of traces metal unsuspended matter of the Scheldt estuary 显示文摘 | Reginer P Wollast R | 1993 | Marine Chemistry1993，43，14： | 1 |
| 18 | Antennal responses of four species of tree-killing bark beetles (Coleoptera:Scolytidae) to volatiles collected from beetles,and their host and nonhost conifers显示文摘 | Deepa S P Regine G John H B | 2004 | Chemoecology2004，14，2： | 1 |
| 19 | A phase I trial of continuously infused intratumoral bleomycin for the treatment of recurrent glioblastoma multiforme 显示文摘 | Patchell RA Regine WF Ashton P | 2002 | J Neurooncol2002，60，1： | 1 |
| 20 | A simple in vitro mode to study the release kinetics of liposome encapsulated material显示文摘 | Regine P Cathi D Francis C | 1998 | J Control Rel1998，56，： | 1 |
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