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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Histology of injected autologous fascia in the paralyzed canine vocal fold显示文摘 | REIJONEN P LEIVO L NEVALAINEN T | 2001 | Laryngoscope2001，111，： | 1 |
| 3 | Anti-inflammatory therapy reduces wheezing after bronchiolitis显示文摘 | Reijonen T Korppi M Kuikka L | 1996 | Arch Pediatr Adolesc Med1996，150，： | 1 |
| 4 | Histology of injection autologous fascia in the paralyzed vocal fold显示文摘 | Reijonen P Leivo L Nevalainen T | 2001 | Laryngoscope2001，111，： | 1 |
| 5 | Predictors of asthma three years after hospital admission for wheezing in infancy显示文摘 | REIJONEN T M KOTANIEMI-SYRJANEN A KORHONEN K | 2000 | Pediatrics2000，106，6： | 1 |
| 6 | Eosinophil activity in infants hospitalized for wheezing and risk of persistent childhood asthma 显示文摘 | Hyvarinen M K Kotaniemi-Syrjanen A Reijonen T M | 2010 | Pediatr Allergy Immunol2010，21，11： | 1 |
| 7 | Histology of injection autologous fascia in the paralyzed vocal fold显示文摘 | Reijonen P Leivo L Nevalainen T | 2001 | Laryngoscope2001，111，： | 1 |
| 8 | Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy显示文摘 | Orban T Farkas K Jalahej H Kis J Treszl A Falk B Reijonen H Wolfsdorf J Ricker A Matthews JB | | 0，，04： | 1 |
| 9 | Anti-inflammatory therapy reduces wheezing after bronchiolitis显示文摘 | Reijonen T Korppi M Kuikka L | 1996 | Arch Pediatr Adolesc Med1996，150，5： | 1 |
| 10 | Histology of injected autologous fascia in the paralyzed canine vocal fold显示文摘 | Reijonen P Leivo I Nevalainen T | 2001 | Laryngoscope2001，111，6： | 1 |
| 11 | Anti-inflammatory therapy reduces wheezing after bronchiolitis显示文摘 | REIJONEN T KORPPI M KUIKKA L | 1996 | Arch Pediatr Adolesc Med1996，150，5： | 1 |
| 12 | Allergenspecific immtmoglobulin E antibodies in wheezing infants:The risk for asthma in later childhood显示文摘 | Kotaniemi-Syrja nen A Reijonen TM Romppanen T | 2003 | Pediatrics2003，111，3： | 1 |
| 13 | Eosinophil activity in infants hospitalized for wheezing and risk of persistent childhood asthma显示文摘 | Hyvarinen M K Kotaniemi-Syrjanen A Reijonen T M | 2010 | Pediatr Allergy Immunol2010，21，11： | 1 |
| 14 | Bronchial asthma and hyperreactivity after early childhood bronchiolitis or pneumonia: An 8-year follow-up study显示文摘 | KORPPI M KUIKKA L REIJONEN T | 1994 | Pediatr Adolesc Med1994，148，10： | 1 |
| 15 | Histology of injected autologous fascia in the paralyzed canine vocal fold显示文摘 | Reijonen P Leivo I Nevalainen T | 2001 | Laryngoscope2001，111，： | 1 |
| 16 | Histology of injected autologous fascia in the paralyzed canine vocal fold 显示文摘 | Reijonen P Leivo I Nevalainen T | 2001 | Iaryngoseope2001，111，6： | 1 |
| 17 | Anti-inflammatory therapy reduces wheezing after bronchiolitis显示文摘 | Reijonen T Korppi M Kuikka L | 1996 | Arch Peditr Adolesc Med1996，150，5： | 1 |
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