|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis显示文摘BACKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical intervention.Current diagnostic standard of care is an invasive joint aspiration.Aspirations provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(e.g.bacterial)or non-infectious(e.g.gout).Cultures can take days to result,so decisions about surgery are often made with incomplete data.Novel diagnostics are thus needed.The“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute inflammation.It has been validated in multiple cohorts across heterogeneous clinical settings.AIM To study whether the SMS holds diagnostic validity in determining the etiology of acute arthritis.METHODS We conducted a blinded,prospective,non-interventional clinical study of the SMS.All patients undergoing work-up for a septic primary joint were enrolled.Patients proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String nCounter?.SMS was calculated blinded to clinical results.RESULTS A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative cultures.The SMS had an area under the ROC curve(AUROC)of 0.87 for separating infectious from non-infectious conditions.For comparison,the AUROCs for ESR=0.58,CRP=0.6,and WBC=0.59.At 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further intervention.CONCLUSION In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic biomarkers.This quick blood test could be an important tool for early,accurate identification of acute septic joints and need for emergent surgery,improving clinical care and healthcare spending. | Blake J Schultz Timothy Sweeney Malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri Michael J Gardner | 2019 | World Journal of Orthopedics2019，10，12： | 1 |
| 2 | Functional analy-sis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes显示文摘 | ZHOU J ARGIKAR U A REMMEL R P | 2011 | Pharmacogenomics2011，12，12： | 1 |
| 3 | Glass-Ceramic Materials of the System BaO-CaO-SiO2 as Sealants for FOFC显示文摘 | Gross S M Koppitz T Remmel J | 2005 | Ceramic Engineering and Science Proceedings2005，26，4： | 1 |
| 4 | Enumerating (2+2)-free posets by the number of minimalelements and other statistics 显示文摘 | Kitaev S Remmel J | 2011 | Discrete Mathematics2011，159，17： | 1 |
| 5 | IntCa104 tenestrial radiocarbon age calibration, 0-26 cal kyr BP 显示文摘 | Reimer P J Baillie M G L Bard E Bayliss A Beck J W Bertrand C J H Blackwell P G Buck C E Burr G S Cutler K B Damon P E Edwards R L Fairbanks R G Friedrich M Guilderson T P Hogg A G Hughen K A Kromer B McCormac G Manning S Ramsey C B Reimer R W Remmele S S J R Stuiver M Talamo S Taylor F W van der Plicht J Weyhenmeyer C E | 2004 | Radiocarbon2004，46，3： | 1 |
| 6 | Glucuronidation of dihydrotestosterone and transandrosterone by recombinant UDP-glucuronosyltransferase(UGT)1A4:evidence formultiple UGT1A4 aglycone binding sites显示文摘 | Zhou J Tracy TS Remmel RP | | 0，，03： | 1 |
| 7 | Exploring spatial variety in patterns of activity - travel behaviour: initial results from the Toronto Travel - Activity Panel Survey ( TTAPS ) 显示文摘 | Buliung R N Roorda M J Remmel T K | 2008 | Transportation2008，35，6： | 1 |
| 8 | The 12,460-year Hohenheim oak and pine tree-ring chronology from Central Europe-- A unique annual record for radiocarbon calibration and palaeo-environment reconstructions显示文摘 | Friedrich M Remmele S Kromer B Hoffmann J Spurk M Kaiser K F Orcel C K ppers M | | 0，，： | 1 |
| 9 | Reperfusion after severe local perfusion deficit precedes hemorrhagic transformation: an MRI study in acute stroke patients 显示文摘 | Fiehler J Remmele C Kucinski T | 2005 | Cerebrovasc Dis2005，19，： | 1 |
| 10 | Marine14 Marine radiocarbon age calibration, 0-26 cal kyr BP 显示文摘 | Hughen K A Baillie M G Bard E Beck J W Bern'and C J H Blackwell P G Buck C E Burr G S Cutler K B Damon P E Edwards R L Fairbanks R G Friedrich M Guilderson T P Kromer B McCormac G Manning S Ramsey C B Reimer P J Reimer R W Remmele S Southon J R Stuiver M Talamo S Taylor F W van der Plicht J Weyhenmeyer C E | 2004 | Radiocarbon2004，46，3： | 1 |
| 11 | Correlation be tween bilirubin glucuronidation and estradiol 3-gluronidation in the presence of model UGT1A1 substrates/inhibitors显示文摘 | Zhou J Tracy TS Remmel RP | 2011 | Drug Metab Dispos2011，39，2： | 1 |
| 12 | IntCal04 terrestrial radiocarbon age calibration, 0- 26 cal kyr BP 显示文摘 | Reimer P J Baillie M G L Bard E Bayliss A Beck J W Bertrand C J H Blackwell P G Buck C E Burr G S Cutler K B Damon P E Edwards R L Fairbanks R G Friedrich M Guilderson T P Hogg A G Hughen K A Kromer B McCormac G Manning S Ramsey C B Reimer R W Remmele S Southon J R Stuiver M Talamo S Taylor F W van der Plicht J Weyhenmeyer C E | 2004 | Radiocarbon2004，46，3： | 1 |
| 13 | Incorporation of an isoleucine zipper motif enhances the biological activity of soluble CD40L(CD154)显示文摘 | Morris A E Remmele R J Klinke R | 1999 | J Biol Chem1999，274，1： | 1 |
| 14 | Interstitial ehemotherapy of experimental gliomas显示文摘 | Zeller WZ Bauer S Remmele J | 1990 | Cancer treat Rev1990，17，： | 1 |
| 15 | Reperfusion after severe local perfusion deficit precedes hemorrhagic transformation:an MRI study in acute stroke patients显示文摘 | Fiehler J Remmele C Kucinski T | 2005 | Cerebrovasc Dis2005，19，： | 1 |
| 16 | Reperfusion after severe local perfusion deficit precedes hemorrhagic transformation: an MRI study in acute stroke patients显示文摘 | Fiehler J Remmele C Kucinski T | 2005 | Cerebrovasc Dis2005，19，： | 1 |
| 17 | Reperfusion after severe local perfusion deficit precedes hemorrhagic transformation: an MR1 study in acute stroke patient 显示文摘 | Fiehler J Remmele C Kucinski T | 2005 | Cerebrovasc Dis2005，19，： | 1 |
| 18 | Functional analysis of UGTIA4 (P24T) and UGT1A4 (L48V) variant enzymes 显示文摘 | ZHOU J ARGIKAR U A REMMEL R P | 2011 | Pharmacogenomics2011，12，12： | 1 |
| 19 | Peperfusion after severe local perfusion deficit precedes hemorrhagic transformation: An MRI study in acute stroke patien显示文摘 | Fiehler J Remmele C Kucinski T | 2005 | Cerebrovasc Dis2005，19，117： | 1 |
| 20 | Simultaneous analysis of cytochrome P450 probes-dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-mass-spectrometry/fluorescence after single-step extraction from plasma显示文摘 | KUMARA A MANNA H J REMMEL RP | 2007 | Journal of Chromatography B2007，853，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员