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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Future technology-enabled care for diabetes and hyperglycemia in the hospital setting显示文摘Patients with diabetes are increasingly common in hospital settings where optimal glycemic control remains challenging.Inpatient technology-enabled support systems are being designed,adapted and evaluated to meet this challenge.Insulin pump use,increasingly common in outpatients,has been shown to be safe among select inpatients.Dedicated pump protocols and provider training are needed to optimize pump use in the hospital.Continuous glucose monitoring(CGM)has been shown to be comparable to usual care for blood glucose surveillance in intensive care unit(ICU)settings but data on cost effectiveness is lacking.CGM use in non-ICU settings remains investigational and patient use of home CGM in inpatient settings is not recommended due to safety concerns.Compared to unstructured insulin prescription,a continuum of effective electronic medical record-based support for insulin prescription exists from passive order sets to clinical decision support to fully automated electronic Glycemic Management Systems.Relative efficacy and cost among these systems remains unanswered.An array of novel platforms are being evaluated to engage patients in technology-enabled diabetes education in the hospital.These hold tremendous promise in affording universal access to hospitalized patients with diabetes to effective self-management education and its attendant short/long term clinical benefits. | Alex Renato Montero Jeffrey S Dubin Paul Sack Michelle F Magee | 2019 | World Journal of Diabetes2019，10，9： | 2 |
| 3 | Gr1+ inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii显示文摘 | Ildiko D Renato D Blima F | 2008 | Immunity2008，29，2： | 1 |
| 4 | Impacts of land use conflicts on riverine ecosystems 显示文摘 | Renato F Valle Junior Simone G P Varandas Femando A L Pacheco | 2014 | Land Use Policy2014，43，： | 1 |
| 5 | A Global-rank-ing Local Feature Selection Method for Text Categorization显示文摘 | Roberto H W George D C Renato F C | 2012 | Expert Systems with Applications2012，39，12： | 1 |
| 6 | Fractional nonablative 1 540-nm laser treatment of striae distensae in Fitzpatrick skin types II to IV:clinical and histological re- sults显示文摘 | de Angelis F Kolesnikova L Renato F | 2011 | Aesthet Surg J2011，31，4： | 1 |
| 7 | Phenotypic and functional characteristics of tumor-derived microvascular endothelial cells显示文摘 | Giulio A Renato GS Simona F | 1999 | Clin Expe Metast1999，17，： | 1 |
| 8 | Experimental and modeling analysis of the NOxOUT process显示文摘 | Renato Rota Dorota Antosl Everton F Zanoelo | 2002 | Chemical Engineering Science2002，，57： | 1 |
| 9 | Three-dimensional digital model of a maize plant显示文摘 | RENATO P WITOLD F | 2010 | Agricultural and Forest Meteorology2010，150，3： | 1 |
| 10 | Cadmium stress in sugar cane callus cultures: Effect on antioxidant enzymes显示文摘 | Ricardo F F Renato R F Guilherme J G P | 2002 | Plant Cell Tissue and Organ Culture2002，71，： | 1 |
| 11 | The effectiveness of continuing education in postoperative pain management:Results from a follow-up study显示文摘 | Ilario G Renato T Francesca F | 2008 | The Journal of Continuing Education in Nursing2008，39，6： | 1 |
| 12 | Fractional nonablative 1540-nm laser treatment of striae distensae in Fitzpatrick skin types I1 to 1V: clinical and histological results 显示文摘 | deAngelis F Kolesnikova L Renato F | 2011 | Aesthet Surg J2011，31，4： | 1 |
| 13 | High reproducibil- ity of serum anti-mullerian hormone measurements sug- gests a multi-staged follicular secretion and strengthens its role in the assessment of ovarian follicular status 显示文摘 | Renato F JoLle T Lozano DHM | 2005 | Human Reproduction2005，20，4： | 1 |
| 14 | Technical inefficiency and production risk in rice farming: evidence from Central Luzon Philippines 显示文摘 | RENATO V EUAN F | 2006 | Asian Economic Journal2006，20，1： | 1 |
| 15 | Analysis of the thermal DeNOx process at high partial pressure of reactants显示文摘 | ROTA RENATO ZANOELO EVERTON F ANTOS DOROTA | 2000 | Chemical Engineering Science2000，55，6： | 1 |
| 16 | Sensitivity of Chlamydia suis to cathelicidin peptides显示文摘 | MANUELA D ANTONIETTA D F RENATO G | 2007 | Vet Mi-crobiol2007，123，11： | 1 |
| 17 | Molecular model of cyclin-dependent kinase S complexed with roscovitine显示文摘 | Walter F A Renato T G Fernanda C | 2002 | Biochem Biophys Res Commun2002，297，5： | 1 |
| 18 | Finding a maximum skewness portfolio a general solution to three moment portfolio choice 显示文摘 | GUSTAVO M A RENATO G F | 2004 | Journal of Economic Dynamics and Control2004，28，7： | 1 |
| 19 | Experimental and modeling analysis of the NO x OUT process显示文摘 | Renato Rota Dorota Antos éverton F Zanoelo Massimo Morbidelli | 2002 | Chemical Engineering Science2002，，1： | 1 |
| 20 | Metal concentrations in surface water and sediments from Pardo River,Brazil:Human health risks显示文摘 | Renato I S A Carolina F S Marti Nadal | 2014 | Environmental Research2014，133，： | 1 |
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