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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model显示文摘骨头骨折愈合的起始的煽动性的阶段为愈合的过程的结果代表关键步。然而,开始这个煽动性的阶段的机制和在破裂地点在场的有免疫力的房间的功能糟糕被理解。以便在破裂 hematoma 以内学习早事件,我们建立了一在里面 vitro 破裂 hematoma 模型:我们有教养的 hematomas 在 bioenergetically 控制的条件下面在 vitro 在全部的新潮的关节造形术(THA ) 期间在腿节的截骨术(人工的骨头破裂) 期间形成。这个模型允许我们在跟随破裂的早阶段期间监视有免疫力的房间人口,房间幸存和 cytokine 表示。而且,这个模型使我们能改变 bioenergetical 条件以便模仿在里面 vivo 状况,它被假定被组织缺氧描绘并且限制了营养素的数量。用这个模型,我们发现有免疫力的房间经由 angiogenic 因素, chemoattractants 和支持 inflammatory 分子的表示适应组织缺氧。另外,联合了氧的限制,滋养的供应与 myeloid 的比较提高了淋巴细胞的选择幸存导出的房间(即, neutrophils ) 。笔记,非限制的 bioenergetical 条件没关于 cytokine 表示或有免疫力的房间子集的不同幸存率显示出任何类似的效果。在结论,我们发现 bioenergetical 条件在导致骨折愈合的起始的煽动性的阶段的关键因素之中并且因此是为在早破裂 hematoma 影响有免疫力的房间的幸存和功能的一个关键步骤。 | Paula Hoff Patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode Gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 3 | Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme pyrrolo-quinoline-quinone:nuleotide sequence and expression in Escherichia coli K-12显示文摘 | Goosen N Harold P A H Rene G M H | 1989 | J Bacteriol1989，171，1： | 1 |
| 4 | Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite 显示文摘 | Rene Haskew Jennifer Wacker | 2001 | European Journal of Pharmacology2001，415，： | 1 |
| 5 | Field dvices-models and their Realisation显示文摘 | RENE S PETER N CHRISTIAN D | 2002 | Industrial Technology2002，4，： | 1 |
| 6 | High-oxygen packaging atmosphere influences protein oxidation and tenderness of porcine longissimus dorsi during chill storage 显示文摘 | Marianne N Lund Rene ' Lametsch Marchen S Hviid | 2007 | Meat Science2007，，77： | 1 |
| 7 | Relationship be- tween fluorouracil systemic exposure and tumor response and patient survival 显示文摘 | MILANO G ETIENNE M C RENEE N | 1994 | J Clin Oncol1994，12，6： | 1 |
| 8 | Lndertreatment of symptoms in patients on maintenance hemodialysis显示文摘 | Rene N Claxton MD Leslie Blackhall MD | 2010 | Pain symptom Manage2010，39，： | 1 |
| 9 | Short bowel syndrome and crohn’s disease显示文摘 | Jon S Thompson Kishore R Iyer John K DiBaise Renee L Young Cindy R Brown Alan N Langnas | 2003 | Journal of Gastrointestinal Surgery2003，，8： | 1 |
| 10 | Modeling MOV-protected series capacitors for short-circuit studies显示文摘 | Coursol M Chinh T N Rene L | | 0，，01： | 1 |
| 11 | Supramaximal dose of candesartan in proteinuric renal disease显示文摘 | Burgess E Muirhead N Rene de Cotret P | 2009 | J Am Soc Nephrol2009，20，4： | 1 |
| 12 | Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite 显示文摘 | JEFFREY N RENE H JENNIFER W | 2001 | Eur J Pharm Sci2001，415，23： | 1 |
| 13 | Pharmacokinetics of sunitinib in hemodialysis 显示文摘 | IZZEDINE H ETIENNE - GRIMALDI M C RENEE N | 2009 | Ann Oncol2009，20，1： | 1 |
| 14 | Isolation, immortal - lization,and charact- erization of a humanbreast epithelial cell linewith stem cell properties显示文摘 | Thorarinn G Rene V Helga L N | 2002 | Genes Dev2002，16，6： | 1 |
| 15 | Sedative and anxiolytic effects of zopichme's enantiomers and metabolite 显示文摘 | Jeffrey N C Rene H Jennifer W | 2001 | European Journal Pharmacology2001，415，： | 1 |
| 16 | Low temperature anaerobic digestion of mixtures of llama, cow and sheep manure for im- proved methane production显示文摘 | Rene' Alvarez Gunnar Lide'n | 2009 | Biomass and Bioenergy2009，33，： | 1 |
| 17 | Endodesmia-diol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides 显示文摘 | Erasmienne T N Rene S F Silvere N | 2008 | Chem Pharm Bull2008，56，3： | 1 |
| 18 | Development of a nucleoprotein-based enzyme-linked immunosorbent assay using a synthetic peptide antigen for detection of avian metapneumovirus antibodies in Turkey sera 显示文摘 | Rene A Kariuki M N Melissa S | 2004 | Clin Diang Lab Immun2004，，24： | 1 |
| 19 | Central nervous system depressant action of flavonoid glycosides显示文摘 | Sebastián P. Fernández Cristina Wasowski Leonardo M. Loscalzo Renee E. Granger Graham A.R. Johnston Alejandro C. Paladini Mariel Marder | 2006 | European Journal of Pharmacology2006，，3： | 1 |
| 20 | The factor age and the recovery of severely burned children 显示文摘 | RENE PRZKORA DAVID N HERNDON MARC G JESCHKE | 2008 | BURNS2008，34，1： | 1 |
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