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| 1 | Chimeric Newcastle Disease Virus-like Particles Containing DC-Binding Peptide-Fused Haemagglutinin Protect Chickens from Virulent Newcastle Disease Virus and H9N2 Avian Influenza Virus Challenge显示文摘Newcastle disease virus(NDV)and H9N2 subtype Avian influenza virus(AIV)are two notorious avian respiratory pathogens that cause great losses in the poultry industry.Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses,while an attenuated live vaccine bears the risk of mutation.Dendritic cell(DC)targeting strategies are attractive for their potent mucosal and adaptive immune-stimulating ability against respiratory pathogens.In this study,DC-binding peptide(DCpep)-decorated chimeric virus-like particles(cVLPs),containing NDV haemagglutinin–neuraminidase(HN)and AIV haemagglutinin(HA),were developed as a DC-targeting mucosal vaccine candidate.DCpep-decorated cVLPs activated DCs in vitro,and induced potent immune stimulation in chickens,with enhanced secretory immunoglobulin A(sIgA)secretion and splenic T cell differentiation.40μg cVLPs can provide full protection against the challenge with homologous,heterologous NDV strains,and AIV H9N2.In addition,DCpep-decorated cVLPs could induce a better immune response when administered intranasally than intramuscularly,as indicated by robust s IgA secretion and a reduced virus shedding period.Taken together,this chimericVLPs are a promising vaccine candidate to control NDV and AIV H9N2 and a useful platform bearing multivalent antigens. | Xiaohong Xu Jing Qian Lingsong Qin Jindou Li Cong Xue Jiaxin Ding Weiqi Wang Wei Ding Renfu Yin Ningyi Jin Zhuang Ding | 2020 | Virologica Sinica2020，35，4： | 4 |
| 2 | H5N6禽流感病毒的基因起源、进化和流行显示文摘2014~2016年间对我国16个省份活禽市场的监测,共鉴定了3174份流感阳性样品,分离并测序了1135份禽流感病毒,分属于31种亚型。 | yuhai bi quanjiao chen qianli wang jianjun chen tao jin gary wong chuansong quan jun liu jun wu renfu yin lihua zhao mingxin li zhuang ding rongrong zou wen xu hong li huijun wang kegong tian guanghua fu yu huang alexander shestopalov shoujun li bing xu hongjie yu tingrong luo lin lu xun xu yang luo 刘映霞 史卫峰 刘翟 高福 | 2017 | 科学新闻2017，0，4： | 2 |
| 3 | Selection and evaluation of stable housekeeping genes for gene expression normalization in carbon nanoparticle-induced acute pulmonary inflammation in mice显示文摘 | Renfu Yin Furong Tian Birgit Frankenberger Martin Hrabé de Angelis Tobias Stoeger | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 1 |
| 4 | Inhibition of Newcastle disease virus replication by RNA interference targeting the matrix protein gene in chicken embryo fibroblasts显示文摘 | Renfu Yin Zhuang Ding Xinxin Liu Lianzhi Mu Yanlong Cong Tobias Stoeger | 2010 | Journal of Virological Methods2010，，1： | 1 |
| 5 | An improved reverse genetics system for Newcastle disease virus genotype Ⅶ显示文摘Dear Editor,Newcastle disease virus(NDV),also known as avian paramyxovirus serotype 1(APMV-1),is a member of the genus Avulavirus within the family Paramyxoviridae,order Mononegavirales(Miller et al.,2010).Although all isolated NDV strains belong to a single serotype,epidemiological studies have revealed that the genotype | Yuzhang Sun Mingjun Sun Yonglian Dai Renfu Yin Zhuang Ding | 2016 | Virologica Sinica2016，31，6： | 1 |
| 6 | Inhibition of New- castle disease virus replication by RNA interference targeting the matrix protein gene in chicken embryo fibroblasts显示文摘 | Renfu Yin Zhuang Ding Xinxin Liu | 2010 | Journal of Virological Methods2010，167，： | 1 |
| 7 | Inhibition of Newcastle disease virus replication by RNA interference targeting the matrix protein gene in chicken embryo fibroblasts显示文摘 | Renfu Yin Zhuang Ding Xinxin Liu Lianzhi Mu Yanlong Cong Tobias Stoeger | 2010 | Journal of Virological Methods2010，，1： | 1 |
| 8 | CASCIRE surveillance network and work on avian influenza viruses显示文摘Studies on influenza virus by Chinese Academy of Sciences(CAS)could be traced back as early as 2005 by the CAS Key Laboratory of Pathogenic Microbiology and Immunology(CASPMI),who discovered that Qinghai-like Clade 2.2H5N1 subtype highly pathogenic avian influenza virus(HPAIV)first caused severe outbreak in wild birds in Qinghai Lake(Liu et al.,2005). | Yuhai Bi Weifeng Shi Jianjun Chen Quanjiao Chen Zhenghai Ma Gary Wong Wenxia Tian Renfu Yin Guanghua Fu Yongchun Yang William J.Liu Chuansong Quan Qianli Wang Shenghu He Xiangdong Li Qianfeng Xia Lixin Wang Zhaohui Pan Laixing Li Hong Li Wen Xu Ying Luo Hui Zeng Lianpan Dai Haixia Xiao Kirill Sharshov Alexander Shestopalov Yi Shi Jinghua Yan Xuebing Li Yingxia Liu Fumin Lei Wenjun Liu George F.Gao | 2017 | Science China(Life Sciences)2017，60，12： | 0 |
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