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12篇 您的检索式:作者名="Renia"
    题名 作者 年代 出处 被引量
1In vitro activity of CD4+ and CD8+ T lymphocytes from mice immunized with a synthetic malaria peptide显示文摘Renia L Marussig MS Grillot D et ol 1991Proc Natl Acad Sci USA1991,88,18:1
2Malaria spomzoite : migrating for a living 显示文摘SILVIE O FRANETICH J F RENIA L 2004Trends Mol Med2004,10,3:1
3Effector functions of circumsporozoite peptide-primed CD4+ T cell clones against Plasmodium yoelii liver stages显示文摘Renia L Grillot D Marussig M 1993J Immunol1993,150,4:1
4In vivo induction of the nitric oxide pathway in hepatocytes after injection with irradiated malaria sporozoites, malaria blood parasites or adjuvants显示文摘Nussler AK Renia L Pasquetto V 1993Eur J Immunol1993,23,4:1
5Targeting the olfactory bulb during ex- perimental cerebral malaria 显示文摘Renia L Howland SW 2014Trends Parasitol2014,,:1
6Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells显示文摘Tourneur L Mistou S Michiels F M Devauchelle V Renia L Feunteun J 2003Oncogene2003,22,:1
7Inhibitory activity of IL-6 on malaria hepatic stages 显示文摘Pied S Renia L Nussler A 1991Parasite Immunol1991,13,2:1
8Effects of hepatocellular iron imbalance on nitric oxide and reactive oxygen intermediates production in a model of sepsis显示文摘Jung M Drapier JC Weidenbach H Renia L Oliveira L Wang A 2000J Hepatol2000,33,3:1
9Current status of the TPS technology in the world 显示文摘Almekinders C J M Chilver A S Renia tl M 1996Potato Research1996,39,2:1
10Targeting Plasmodium PI4K to eliminate malaria 显示文摘McNamara CW Lee MC Lim CS Lim SH Roland J Nagle A Simon O Leung BK Chatterjee AK McCormack SL Manary MJ Zeeman AM Dechering KJ Kumar TR Henrich PP Gagaring K Ibanez M Kato N Kuhen KL Fischli C Rottmann M Plouffe DM Bursulaya B Meister S Rameh L Trappe J Haasen D Timmerman M Sauerwein RW Suwanarusk R Russell B Renia L Nosten F Tully DC Kocken CH Glynne RJ Bodenreider C Fidock DA Diagana TT Winzeler EA 2013Nature2013,504,7479:1
11Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo显示文摘Vincent O. Mallet Claudia Mitchell Eva Mezey Monique Fabre Jacques-Emmanuel Guidotti Laurent Renia Laure Coulombel Axel Kahn Hélène Gilgenkrantz 2002Hepatology2002,,4:1
12Engineering immunosuppressive drug-resistant armored(IDRA)SARS-CoV-2 T cells for cell therapy显示文摘Solid organ transplant(SOT)recipients receive immunosuppressive drugs(ISDs)and are susceptible to developing severe COVID-19.Here,we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients(n=136)treated with different ISDs.We demonstrate that a combination of a calcineurin inhibitor(CNI),mycophenolate mofetil(MMF),and prednisone(Pred)treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular response.Such defects have clinical consequences because the magnitude of vaccine-induced Spike-specific T cells was directly proportional to the ability of SOT patients to rapidly clear SARS-CoV-2 after breakthrough infection.To then compensate for the T-cell defects induced by immunosuppressive treatment and to develop an alternative therapeutic strategy for SOT patients,we describe production of 6 distinct SARS-CoV-2 epitope-specific ISD-resistant T-cell receptor(TCR)-T cells engineered using the mRNA electroporation method with reactivity minimally affected by mutations occurring in Beta,Delta,Gamma,and Omicron variants.This strategy with transient expression characteristics marks an improvement in the immunotherapeutic field and provides an attractive and novel therapeutic possibility for immunosuppressed COVID-19 patients.Qi Chen Adeline Chia Shou Kit Hang Amy Lim Wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti 2023Cellular & Molecular Immunology2023,20,11:0
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