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| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Kinetic model for noncatalytic supercritical water gasification of cellulose and lignin显示文摘 | Resende F L P Savage P E | | 0，，09： | 1 |
| 3 | Ultrasound guided core needle biopsy of breast masses: How many cores are necessary to diagnose cancer? 显示文摘 | De Lucena C E Dos Santos Junior J L De Lima Resende C A | 2007 | J Clin Ultrasound2007，35，7： | 1 |
| 4 | Increase of tospoviral diversity in Brazil with the identification of two new tospoviruses, one from Chrysanthemum and one from Zucchini显示文摘 | Bezerra I C Resende O de Pozzer L | 1999 | Phytopathology1999，89，： | 1 |
| 5 | Widely linear adaptive equalization of digital communication channel 显示文摘 | de Aquino F J A Resende L S da Rocha C A F | 2010 | IEEE Latin America Transactions2010，8，1： | 1 |
| 6 | A damage mechanics constitutive theory for the inelastic behavior of concrete 显示文摘 | Resende L | 1987 | Computer Methods in Applied Mechanics and Engineering1987，60，： | 1 |
| 7 | Damage mechanics constitutive theory for the inelastic behaviour of concrete 显示文摘 | Resende L A | 1987 | Computer Methods in Applied Mechanics and Engineering1987，60，1： | 1 |
| 8 | A fast least squares algorithm for linearly constrained adaptive filtering显示文摘 | Resende L S Romano J M T Bellanger M G | 1996 | IEEE Trans Signal Processing1996，44，3： | 1 |
| 9 | Sputum cytokine levels in patients with pulmonary tuberculosis as early markers of mycobacterial clearance显示文摘 | RIBEIRO RODRIGUES R RESENDE CO T JOHNSON J L | 2002 | Clin Diagn Lab Immunol2002，9，4： | 1 |
| 10 | Catalytic fast pyrolysis of aspen lignin via Py-GC/MS显示文摘 | ZHANG M RESENDE F L P MOUTSOGLOU A | 2014 | Fuels2014，116，0： | 1 |
| 11 | Transient correlation between viremia levels and IL-10 expression in pigs subclinically infected with porcine circovirus type 2(PCV2)显示文摘 | DARWICH L SEGAIéS J RESENDES A | 2008 | Research in Veterinary Science2008，84，2： | 1 |
| 12 | Speeding updynamic shortest-path algorithms显示文摘 | THORUP M BURIOL L S RESENDE M | 2008 | Informs Journal on Computing2008，2，20： | 1 |
| 13 | Sudden bilateral deafness from hyperleukocytosis in chronic myeloid leukemia显示文摘 | Resende L S R Cloradazi A L Rocha C | 2000 | Acta Hematol2000，104，1： | 1 |
| 14 | A Damage Mechanics Constitutive Theory for the Inclastic Behavior of Concrete 显示文摘 | Resende L | 1987 | Computer Methods in Applied Mechanics and Engineering1987，83，6： | 1 |
| 15 | Pelvic floor muscle training for treatment of pelvic organ prolapse:an assessor-blinded randomized controlled trial显示文摘 | Stupp L Resende AP Oliveira E | 2011 | Int Urogynecol J2011，22，10： | 1 |
| 16 | At the speed of sound: Gene discovery in the auditory system显示文摘 | Barbara L Resendes Robin E | 2001 | Am J Hum Genet2001，69，： | 1 |
| 17 | Prevalence of candida spin hospitalized patients and their risk factors显示文摘 | Resnde J C de Resende M A Saliba J L | 2002 | Mgcoses2002，45，8： | 1 |
| 18 | Energy and protein requirements for maintenance and growth of Boer crossbred kids 显示文摘 | FERNANDES M H M R RESENDE K T TEDES- CHI L O | 2007 | J Anim Sci2007，85，4： | 1 |
| 19 | Transient correlation be- tween viremia levels and IL-10 expression in pigs subclinically infec- ted with porcine eircovirus type 2 (PCV2) 显示文摘 | Darwich L Segale J Resendes A | 2008 | Res Vet Sci2008，84，2： | 1 |
| 20 | Energy and protein requirements for mainte-nance and growth of Boer crossbred kids 显示文摘 | FRENANDES M H M R RESENDE K T TEDES-CHI L O | 2007 | Journalof Animal Science2007，85，： | 1 |
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