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| 1 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 2 | The road to bioabsorbable stents:Reaching clinical reality?显示文摘 | Erne P Schier M Resink T J | 2006 | Cardiovascular Int Radiology2006，29，1： | 1 |
| 3 | Pimoide modulates the luteinizing hormone-releasing hormone effect on gonadotropin release in the African catfish显示文摘 | De Leeuw R J W Resink E J M Rooyakers | 1985 | Clarias Lazera Gen Comp Endocrinol1985，58，： | 1 |
| 4 | Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye显示文摘 | Hammer J Pache M and Resink T | 2001 | Prog Retin Eye Res2001，20，3： | 1 |
| 5 | Peptide vasoconstrictors, vessel structure, and vascular smooth - muscle proliferation 显示文摘 | HAHN A W RESINK T J KERN F | 1993 | J Cardiovasc Pharmacol1993，22，5： | 1 |
| 6 | Low- and high-density lipoproteins as mitogenic factors for vascular smooth muscle cells: individual,additive and synergistic effects 显示文摘 | Resink T J Bochkov V N Hahn A W | 1995 | J Vasc Res1995，32，5： | 1 |
| 7 | Penetration of liquid urea-formaldehyde adhesive into beech wood显示文摘 | Sernek M Resink J Kamke F A | 1999 | Wood and Fiber Science1999，19，1： | 1 |
| 8 | The road to bioabsorbable stents: reaching clinical reality? 显示文摘 | Erne P Schier M Resink T J | 2006 | Cardiovasc Intervent Radiol2006，29，： | 1 |
| 9 | The road to bioab- sorbable stents: reaching clinical reality? 显示文摘 | Erne Paul Schier Matthias Resink Therese J | 2006 | Cardiovascular and Interventional Radiology2006，29，1： | 1 |
| 10 | Activation of phospholipase A2 by endothelin in cultrued vascular smooth muscle cells显示文摘 | Resink TJ Scott-Barden J Buhler FR | 1989 | Biochem Biophys Res Commun1989，158，12： | 1 |
| 11 | The seminal vesicle as source of sex attracting substances in the African catfish, Clarias gariepinus显示文摘 | Hurk R V D Zoelen R F O G V | 1987 | Aquaculture1987，63，： | 1 |
| 12 | The chemical nature of sex attracting pheromones from the seminal vesicle of the African catfish Clarias gariepinus显示文摘 | Schoonen W G E J Albers P C H | 1989 | Aquaculture1989，83，： | 1 |
| 13 | Phero- mone detection and olfactory pathways in the brain of female African catfish, Clarias gariepinus显示文摘 | Resink J W Voorthuis P K Van Den Hurk R | 1989 | Cell Tissue Res1989，256，2： | 1 |
| 14 | Male reproductive system as sex pheromone producer in teleost fish显示文摘 | Resink J W | 1992 | J Exp Zool1992，261，： | 1 |
| 15 | Cellular signalling by lipoprotein in cultured smooth muscle cells from spontaneously hypertensive rals 显示文摘 | Resink TJ Rybin V Bernhardt J | 1993 | J Vasc Res1993，30，3： | 1 |
| 16 | The Road to Bioabsorbable Stents: Reaching Clinical Reality 显示文摘 | Erne P Schier M Resink T J | 2006 | Cardiovasc lntervent Radi- ol2006，，29： | 1 |
| 17 | Male reproductive-system as sex-pheromone producer in teleost fish 显示文摘 | VAN DEN HURK R RESINK J W | 1992 | Jour Exp Zool1992，261，2： | 1 |
| 18 | Induction of gonadotropin release andovulation by pheromone in the African catfish, Clarias gariepiuus 显示文摘 | RESINK J W VAN DEN BERG T W M VAN DEN HURK R | 1989 | Aquaculture1989，83，： | 1 |
| 19 | 显示文摘 | Resink TJ Bernhardt J | 1991 | Biochem Biophys Res Commun1991，178，： | 1 |
| 20 | Steroid glucuronides as male pheromones in the reproduction of the African catfish Clarias gariepinus-a brief review显示文摘 | Lambert J G Resink J W | 1991 | The Journal of Steroid Biochemistry and Molecular Biology1991，40，： | 1 |
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