维普中文期刊产品整合服务
58篇 您的检索式:作者名="Revilla L"
    题名 作者 年代 出处 被引量
1Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns 2015World Journal of Gastroenterology2015,21,17:4
2Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats显示文摘Gomez-Amores L Mate A Revilla E 2006Life Sci2006,78,17:1
3Studies on the hydraulic behaviour ofstepped spillways显示文摘DIEZ-CASCON J BLANCO J L REVILLA J and GARCIA R 1991Water Power and Dam Construction1991,,9:1
4Isolation of endophytic di- azotrophic bacteria from wetland rice显示文摘Barraquio W L Revilla and Ladha JK 1997Plant and Soil1997,194,:1
5Isolation of endophytic bacteria from wetland rice显示文摘Barraquio W L Revilla L Ladha J K 1997Plant and Soil1997,194,:1
6Pbenotypie characterization of pig IFN-γ-producing lym- phocytes by flow cytometry 显示文摘Rodriguez-Carreno M P Lopez-Fuertes L Revilla C 2002Journal of Immunological Methos2002,259,12:1
7The decision of the supply chain executive to support or impede supply chain integration: A muhidisciplinary behavioral agency perspective显示文摘Villena V H Gomez Mejia L R Revilla E 2009Decision Sciences2009,40,4:1
8Expression of the neuronal calcium sensor protein family in the rat brain 显示文摘Paterlini M Revilla V Grant A L 2000Neuroscience2000,99,2:1
9Epigenetic changes detected in micropropagated hop plants显示文摘Peredo E L Arroyo-Garcia R Revilla M 2009Plant Physiol2009,166,:1
10Antioxidant activity of propionyl-L-carnitine in liver and hear of spontaneously hypertensive rats显示文摘Gomez A L Mate A Revilla E 2006Life Sci2006,78,17:1
11Transient dissociation of bone metabolism induced by high performance exercise:a study in elite marathon runners显示文摘Crespo R Revilla M Villa L F 1999Calcif Tissue Int1999,64,:1
12Multivariate evaluation of changes induced in red wine characteristics by the use of extracting agents显示文摘Revilla I Gonzalez-SanJose M L 2002J Agric Food Chem2002,50,16:1
13Determination of rimantadine in pharmaceutical preparations by capillary zone electrophoresis with indirect detection or after derivatization显示文摘REVILLA A L HAMACEK J LUBAL P 1998Chromatogr1998,47,78:1
14Does the bathing water classification depend on sampling strategy? A bootstrap approach for bathing water quality assessment, according to Directive 2006/7/EC requirements显示文摘Iago López César álvarez José L. Gil José A. Revilla 2012Journal of Environmental Management2012,,:1
15Differentiating the workforce:the performance effects of using contingent labor in a context of high-performance work systems显示文摘STIRPE L BONACHE J REVILLA A 2014Journal of Business Research2014,67,7:1
16MASON: A multiagent simulation environment显示文摘Luke S Ciofi%Revilla C Panait L 2005Simulation2005,81,7:1
17Isolation of endophytic diazotrophic bacteria from wetland rice 显示文摘Barraquio W L Revilla L Ladha J K 1997Plant and Soil1997,194,1:1
18Methanol release during fermentation of red grapes treated with pectolytic enzymes显示文摘REVILLA I GONZ LEZ-SANJOS M L 1998Food chemistry1998,,3:1
19Identification of anthocyanin derivatives in grape skin extracts and red wines by liquid chromatography with diode array and mass spectromet- ric detection显示文摘REVILLA I PEREZ-MAGARINO S GONZALEZ-SANJOSE M L 1999Journal of Chromatography A1999,847,12:1
20Capillary zone electrophoresis of hydroxynaphthalenecarboxylic acids - Purity monitoring ofβ-ydroxynaphthoic acid in industry 显示文摘Revilla A L Havel J Borovcova J 1997Journal of Chromatography A1997,772,:1
返回顶部 每页显示:
共3页 首页 上一页 第1页 下一页 末页 /3 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费