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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | American College of Gastroenterology guidelines for colorectal cancer screening 2009显示文摘 | REX D K JOHNSON D A ANDERSON J C | 2009 | Am J Gastroenterol2009，104，3： | 1 |
| 4 | Vascular signal transducerand activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke显示文摘 | Hoffmann C J Harms U Rex A | 2015 | Circulation2015，131，20： | 1 |
| 5 | Radical hysterectomy and pelvic lymphadenectomy for stage IB2 cervical cancer显示文摘 | Laura J Havrilesky Charles A Leath Warner Huh Brian Calingaert Rex C Bentley John T Soper Angeles Alvarez Secord | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 6 | Screening and surveillance for eolorectal cancer: state of the art 显示文摘 | KAHI C ANDERSON J C REX D K | 2013 | Ga~rointest Endosc2013，77，： | 1 |
| 7 | Keratinocyte growth factor protects mice from chemotherapy and radiation - in- duced gastrointestinal injury and mortality显示文摘 | FARRELL C L BREADY J V REX K L | 1998 | Cancer Research1998，58，5： | 1 |
| 8 | Cooling and uplift histories of the crystalline thrust stack of the Indian Plate internalzones west of Nanga Parbat, Pakistan Himalaya显示文摘 | TRELOAR P J REX D C | 1990 | Tectonophysics1990，180，： | 1 |
| 9 | Management of primary cutaneous melanoma of the hands and feet: A clinicoprognostic study 显示文摘 | Rex J Paradelo C Mangas C | 2009 | Dermatol Surg2009，35，10： | 1 |
| 10 | Correlated memory defects and hippocampal dendritic spine loss after acute stress involve cortico- tmpin-releasing hormone signaling显示文摘 | Chen Y Rex CS Rice C J | 2010 | Pmc Nat] Acad Sci USA2010，107，13： | 1 |
| 11 | Rectovaginal fistula:complication of low anteriorresection显示文摘 | Rex J C Khubchandani I T | 1992 | Dis Colon Rectum1992，35，： | 1 |
| 12 | Bowel obstruction and pseudo-obstruction显示文摘 | Kahi C J Rex DK | 2003 | Gastroenterol Clin North Am2003，32，4： | 1 |
| 13 | Biofiltration for removal of BOM and residual ammonia following control of bromate formation 显示文摘 | Weft E C Neemann J J Rexing D J | 2008 | Water Res2008，42，1： | 1 |
| 14 | Ozone oxidation of endocrine disruptors and pharmaceuticals in surface water and wastewater显示文摘 | SNYDER S A WERT E C REXING D J | 2006 | Ozone:Science and Engineering2006，28，6： | 1 |
| 15 | Biofiltration for removal of BOM and residual ammonia following control of bromate formation显示文摘 | WERT E C NEEMANN J J REXING D J | 2008 | Water Res2008，42，1： | 1 |
| 16 | Serrated lesions of the colorectum: re-view and recommendations from an expert panel 显示文摘 | Rex D K Ahnen D J Baron J A Batts K P Burke C A Burt R W | 2012 | Am J Gastroenterol?2012，107，： | 1 |
| 17 | Analysis and modeling of intermediate-scale reservoir heterogeneity based on a fluvial point-bar outcrop analog, Williams Fork Formation, Piceance Basin, Colorado 显示文摘 | MATI'EW J P AMANDA I E REX D C | 2007 | AAPG Bulletin2007，91，7： | 1 |
| 18 | Registered nurse-administered propofol sedation for upper endoscopy and colonoscopy:Why? When? How?显示文摘 | REX D K OVERLEY C A WALKER J | 2003 | Rev Gastroenterol Disord2003，3，2： | 1 |
| 19 | Detection of amphotericin B-resistant Candida isolates in a broth-based system显示文摘 | Rex J H Cooper C R Jr Merz W G | 1995 | Antimicrob Agents Chemother1995，39，4： | 1 |
| 20 | Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and US Multi-Society Task Force on Colorectal Cancer 显示文摘 | Rex DK Kahi C J Levin B | 2006 | CA Cancer J Clin2006，56，3： | 1 |
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