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| 1 | Predictive biomarkers in precision medicine and drug development against lung cancer显示文摘The molecular characterization of various cancers has shown that cancers with the same origins,histopathologic diagnoses,and clinical stages can be highly heterogeneous in their genetic and epigenetic alterations that cause tumorigenesis.A number of cancer driver genes with functional abnormalities that trigger malignant transformation and that are required for the survival of cancer cells have been identified.Therapeutic agents targeting some of these cancer drivers have been successfully developed,resulting in substantial improvements in clinical symptom amelioration and outcomes in a subset of cancer patients.However,because such therapeutic drugs often benefit only a limited number of patients,the successes of clinical development and applications rely on the ability to identify those patients who are sensitive to the targeted therapies.Thus,biomarkers that can predict treatment responses are critical for the success of precision therapy for cancer patients and of anticancer drug development.This review discusses the molecular heterogeneity of lung cancer pathogenesis;predictive biomarkers for precision medicine in lung cancer therapy with drugs targeting epidermal growth factor receptor(EGFR),anaplastic lymphoma kinase(ALK),c-ros oncogene 1 receptor tyrosine kinase[ROSl),and immune checkpoints;biomarkers associated with resistance to these therapeutics;and approaches to identify predictive biomarkers in anticancer drug development.The identification of predictive biomarkers during anticancer drug development is expected to greatly facilitate such development because it will increase the chance of success or reduce the attrition rate.Additionally,such identification will accelerate the drug approval process by providing effective patient stratification strategies in clinical trials to reduce the sample size required to demonstrate clinical benefits. | Bingliang Fang Reza J Mehran John V Heymach Stephen G Swisher | 2015 | Chinese Journal of Cancer2015，34，7： | 5 |
| 2 | Gray and White Matter Brain Volume in Aged Rats Raised on n-3 Fatty Acid Deficient Diets显示文摘 | Aneeq A Reza M Peter V G | 2004 | Nutritional Neuroscience2004，7，1： | 1 |
| 3 | Effect of PEG stress on germina- tion indices and seedling growth of 12 bread wheat gentypes显示文摘 | Taregh G Mostafa V Reza S etal | 2011 | Ad- vances in Environmental Biology2011，5，6： | 1 |
| 4 | Global identification of conserved post-transcriptional regulatory programs in trypanosomatids显示文摘 | Hamed S. Najafabadi Zhiquan Lu Chad MacPherson Vaibhav Mehta Véronique Adoue Tomi Pastinen Reza Salavati | 2013 | Nucleic Acids Research2013，，： | 1 |
| 5 | Reliable Design of aLogistics Network under Uncertainty : A Fuzzy Possibilitic-queuing Model显示文摘 | Behnam V Reza T M Fariborz J | 2013 | Applied Mathematical Modeling2013，，37： | 1 |
| 6 | Computer simulation of the optical properties of high- temperature cemet solar selective coating显示文摘 | Reza Nejati M Fathollahi V Khalaji Asadi M | 2005 | Solar Energy2005，78，2： | 1 |
| 7 | Effect of PEG stress on germination indices and seedling growth of 12 bread wheat gentypes 显示文摘 | TAREGH G MOSTAFA V REZA S | 2011 | Advances in Environmental Biology2011，，6： | 1 |
| 8 | Separation of 1-lysine from dilute aqueous solution using molecular imprinting technique显示文摘 | Reza P Ebrahim V F Seyed A S | 2007 | Biochemical Engineering Journal2007，，35： | 1 |
| 9 | Zucker diabetic fatty rat:a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity显示文摘 | Slavkovsky R Kohlerova R Tkacova V Jiroutova A Tahmazoglu B Velebny V Reza?ováM Sobotka L Kanta J | 2011 | Wound Repair Regen2011，19，4： | 1 |
| 10 | Computer simulation of the optical properties of high-temperature cermet solar selective coatings 显示文摘 | Reza Nejati M Fathollahi V Khalaji Asadi M | 2005 | Solar Energy2005，78，2： | 1 |
| 11 | PGC-1[alpha] promotes recovery after acute kidney injury during systemic inflammation in mice显示文摘 | Tran Mei Tam Denise Bardia Amit Bhasin Manoj Rowe Glenn C Kher Ajay Zsengeller Zsuzsanna K Akhavan-Sharif M Reza Khankin Eliyahu V Saintgeniez Magali David Sascha Burstein Deborah Karumanchi S Ananth Stillman Isaac E Arany Zoltan Parikh Sa | 2011 | Journal of Clinical Investigation2011，，10： | 1 |
| 12 | Ultrahigh purcell factors and lamb shifts in slow-light metamaterial waveguides显示文摘 | Yao P J Vlack C V Reza A | | 0，，： | 1 |
| 13 | A two-dimensional flow model for the process simulation of complex shape composite laminates 显示文摘 | Hubert P Reza V Anoush P | 1999 | International Journal of Numerical Mathematic Engineer1999，44，1： | 1 |
| 14 | Separation of L-lysine from di- lute aqueous solution using molecular imprinting technique显示文摘 | REZA P EBRAHIM V F SEYED A S | 2007 | Biochem Eng J2007，35，： | 1 |
| 15 | Comparison of evapotranspiration models for estimating reference evapotranspiration in arid environment显示文摘 | Mohammad M H Reza N N Mohammad V | 2013 | Middle-East Journal of Scientific Research2013，15，9： | 1 |
| 16 | SchaefferChitosan scaffolds: lnterconnective pore size and cartilage engineering 显示文摘 | Dominique J Reza S David V | 2006 | Acta Biomaterialia2006，2，3： | 1 |
| 17 | RSS-based sensor localization in the presence of unknown channel parameters显示文摘 | MOHAMMAND R G REZA M V ERIK G S | 2013 | IEEE Transactions on Signal Processing2013，61，15： | 1 |
| 18 | Cooperative received signal strength-based sensor localization with unknown transmit powers显示文摘 | REZA M V MOHAMMAD R G R M BUEHRER | 2013 | IEEE Transactions on Signal Processing2013，61，6： | 1 |
| 19 | Free Volume and Elastic Properties Changes in Cu-Zr-Ti-Pd Bulk Glassy Alloy on Heating显示文摘 | DMITRI V LOUZGUINE-LUZGIN ALAIN REZA YAVARI MIKIO FUKUHARA | 2007 | Journal of Alloys and Compounds2007，431，： | 1 |
| 20 | Reliable design of a logis- tics network under uncertainty: A fuzzy possibilitic - queuing model 显示文摘 | BEHNAM V REZA T M FARIBORZ J | 2013 | Applied Mathematical Modeling2013，，37： | 1 |
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