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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Montelukast was inefficient in maintaining steroid-induced remission in adult eosinophilic esophagitis 显示文摘 | Lucendo AJ De Rezende LC Jimenez-Contreras S | 2011 | Dig Dis Sci2011，56，12： | 1 |
| 3 | Montelukast was inefficient in maintaining steroid-induced re- mission in adult eosinophilic esophagitis显示文摘 | Lucendo AJ De Rezende LC Jimenez-Contreras S | 2011 | Dig Dis Sci2011，56，12： | 1 |
| 4 | Regulatory T cell as atai^et for cancer therapy 显示文摘 | de Rezende LC Silva IV Rangel LB | 2010 | Arch Immunol Ther Exp ( Warsz)2010，58，3： | 1 |
| 5 | Regulatory T cell as atarget for cancer therapy显示文摘 | de Rezende LC Silva IV Rangel LB | 2010 | Arch Immunol Ther Exp (Warsz)2010，58，3： | 1 |
| 6 | Pelvic peritoneum in male armadillo and anteater (Xenarthra,Mammalia):a comparative survey显示文摘 | Rezende LC Ferreira JR | 2013 | Zoolog Sci2013，30，1： | 1 |
| 7 | Regulatory T cell as a tar-get for cancer therapy显示文摘 | de Rezende LC Silva IV Rangel LB | 2010 | Arch Immunol Ther Exp(Warsz)2010，58，3： | 1 |
| 8 | Evaluation of PvuⅡ and XbaI polymorphisms in the estrogen receptor alpha gene (ESR1) in relation to menstrual cycle timing and reproductive parameters in post-menopausal woman显示文摘 | Silva IV Rezende LC Lanes SP | 2010 | Maturitas2010，67，4： | 1 |
| 9 | 补充维生素D、ω-3脂肪酸或力量训练运动项目对老年人临床结局的影响:DO-HEALTH随机临床试验显示文摘维生素D、ω-3脂肪酸和运动对疾病预防的获益仍不明确。该研究旨在评估维生素D、ω-3脂肪酸和力量训练运动项目单独或联合进行是否可改善老年人6种健康结局。设计、设置和参与者:该试验为双盲、安慰剂对照、2×2×2阶乘随机临床试验,纳入年龄≥70岁的老年人2 157例,参与者纳入时5年内无主要健康事件,有足够的运动能力和良好的认知状况。主要结局和检测指标:6种主要结局为3年间收缩压、舒张压、简易体能状况量表(short physical performance battery,SPPB)、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、非脊柱骨折及感染的发生率。结果:2 157例随机参与者(平均年龄74.9岁,61.7%为女性)中,1 900例(88%)完成研究。 | 袁源(摘译) 练桂丽(审校) Bischoff-Ferrari HA Vellas B Rizzoli R Kressig RW daSilva JAP Blauth M Felson DT McCloskey EV Watzl B Hofbauer LC Felsenberg D Willett WC Dawson-Hughes B Manson JE Siebert U Theiler R Staehelin HB de Godoi Rezende Costa Molino C Chocano-Bedoya PO Abderhalden LA Egli A Kanis JA Orav EJ DO-HEALTH Research Group | 2021 | 中华高血压杂志2021，29，1： | 0 |
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