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| 1 | Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer显示文摘17β-hydroxysteroid dehydrogenase(17β-HSD)type 1 is known as a critical target to block the final step of estrogen production in estrogen-dependent breast cancer.Recent confirmation of the role of dyhydroxytestosterone(DHT)in counteracting estrogeninduced cell growth prompted us to study the reductive 17β-HSD type 7(17β-HSD7),which activates estrone while markedly inactivatingDHT.The role ofDHTin breast cancer cell proliferation isdemonstratedby its independent suppression of cell growthin the presence of a physiological concentration of estradiol(E2).Moreover,an integral analysis of a large number of clinical samples in Oncomine datasets demonstrated the overexpression of 17β-HSD7 in breast carcinoma.Inhibition of 17β-HSD7 in breast cancer cells resulted in a lower level of E2 and a higher level of DHT,successively induced regulation of cyclinD1,p21,Bcl-2,and Bik,consequently arrested cell cycle in the G0/G1 phase,and triggered apoptosis and auto-downregulation feedback of the enzyme.Such inhibition led to significant shrinkage of xenograft tumors with decreased cancer cell density and reduced 17β-HSD7 expression.Decreased plasma E2 and elevated plasma DHT levels were also found.Thus,the dual functional 17β-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of E2 andDHT.Thisdemonstrates aconceptual advance on the general belief that the major role of this enzyme is in cholesterol metabolism. | Xiaoqiang Wang Catherine Gérard Jean-Francois Thériault Donald Poirier Charles J.Doillon Sheng-Xiang Lin | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 2 | MUC16 (CA125) regulates epithelial ovarian cancer cell growth,tumorigenesis and metastasis显示文摘 | Thériault C Pinard M Comamala M | 2011 | Gynecol Oncol2011，121，3： | 1 |
| 3 | Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer显示文摘 | Thériault BL Basavarajappa HD Lim H | 2014 | PLo S One2014，9，91： | 1 |
| 4 | Risk of bladder cancer in foundry workers:a meta-analysis显示文摘 | Gaertner RRW Thériault GP | 2002 | Occup Environ Med2002，59，10： | 1 |
| 5 | Two-dimensional electrophoresis of proteins discriminates aphid clones of Sitobion avenae differing in BYDV-PAV transmission显示文摘 | Papura D Jacquot E Dedryver C A Luche S Riault G Bossis M Rabilloud T | | 0，，： | 1 |
| 6 | Power-frequency electric and magnetic fields and risk of childhood leukemia in Canada显示文摘 | Mc Bride ML Gallagher RP Thériault G | 1999 | Am J Epidemiol1999，149，9： | 1 |
| 7 | Effects of exercise-training and detraining on fat cell lipolysis in men and women显示文摘 | J. P. Després C. Bouchard R. Savard A. Tremblay M. Marcotte G. Thériault | 1984 | European Journal of Applied Physiology and Occupational Physiology1984，，1： | 1 |
| 8 | Overtime work and stress response in a group of Japanese workers显示文摘 | Sato Y Miyake H Thériault G | 2009 | Occup Med(Lond)2009，59，1： | 1 |
| 9 | Kinesin family member 14:an independent prognostic marker and potential therapeutic target for ovarian cancer显示文摘 | TH(E)RIAULT BL PAJOVIC S BERNARDIN MQ | 2012 | Int J Cancer2012，130，8： | 1 |
| 10 | Analysis of Accumulation Patterns of Barley yellow dwarf virus-PAV (BYDV-PAV) in Two Resistant Wheat Lines显示文摘 | Florian Chain Gérard Riault Maxime Trottet Emmanuel Jacquot | 2005 | European Journal of Plant Pathology2005，，4： | 1 |
| 11 | Passive standoff detection of chemical warfare agents on surfaces显示文摘 | THéRIAULT J M PUCKRIN E HANCOCK J | 2004 | Applied Optics2004，43，31： | 1 |
| 12 | Improvement of Barley yellow dwarf virus -PAV detection in single aphids using a fluorescent real time RT-PCR显示文摘 | Frédéric Fabre Christine Kervarrec Lucie Mieuzet Gérard Riault Aude Vialatte Emmanuel Jacquot | 2003 | Journal of Virological Methods2003，，1： | 1 |
| 13 | Passive standoff detection of surface contaminants: a novel approach by differential polarization FTIR spectrometry显示文摘 | LAVOIE H THéRIAULT J M PUCKRIN E | 2008 | International Journal of High Speed Electronics and Systems2008，18，2： | 1 |
| 14 | Analysis of accumulation patterns of barley yellow dwarf virus-PAV (BYDV-PAV) in two resistant wheat lines显示文摘 | Florian Chain Gerard Riault Maxime Trottet | 2005 | European Journal of Plant Pathology2005，113，： | 1 |
| 15 | Fuzzy semantics for direction relations between composite regions显示文摘 | CLARAMUNT C THRIAULT M | 2004 | Information Sciences2004，160，1： | 1 |
| 16 | Analysis of accumulation patterns of Barley yellow dwarf virus-PAV (BYDV-PAV) in two resistant wheat lines 显示文摘 | Chain F Riault G Trotter M | 2005 | European Journal of Plant Pa- thology2005，113，4： | 1 |
| 17 | Accuracy of real-time ultrasound measurements of total tissue,fat,and muscle depths at different measuring sites in lamb显示文摘 | THRIAULT M POMAR C CASTONGUAY F W | 2009 | J Animal Science2009，87，： | 1 |
| 18 | Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer显示文摘 | Brigitte L.Thériault SanjaPajovic Marcus Q.Bernardini Patricia A.Shaw Brenda L.Gallie | 2012 | Int. J. Cancer2012，，： | 1 |
| 19 | Hypoxia alters contractile protein homeostasis in L6myotubes显示文摘 | Marc-AndréCaron Marie-Eve Thériault Marie-ève Paré etal | 2009 | FEBS Lett2009，583，9： | 1 |
| 20 | High-g accelerometer based on an in-fiber bragg grating sensor显示文摘 | Sylvain Thériault Kenneth O. Hill Francois Bilodeau Derwyn C. Johnson Jaques Albert Gédéon Drouin Alain Béliveau | 1997 | Optical Review1997，，1： | 1 |
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