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| 1 | Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease显示文摘Gastro-esophageal reflux disease(GERD)is one of the most prevalent chronic diseases.Although proton pump inhibitors(PPIs)represent the mainstay of treatment both for healing erosive esophagitis and for symptom relief,several studies have shown that up to 40%of GERD patients reported either partial or complete lack of response of their symptoms to a standard PPI dose once daily.Several mechanisms have been proposed as involved in PPIs resistance,including ineffective control of gastric acid secretion,esophageal hypersensitivity,ultrastructural and functional changes in the esophageal epithelium.The diagnostic evaluation of a refractory GERD patients should include an accurate clinical evaluation,upper endoscopy,esophageal manometry and ambulatory pH-impedance monitoring,which allows to discriminate non-erosive reflux disease patients from those presenting esophageal hypersensitivity or functional heartburn.Treatment has been primarily based on doubling the PPI dose or switching to another PPI.Patients with proven disease,not responding to PPI twice daily,are eligible for anti-reflux surgery. | Michele Cicala Sara Emerenziani Michele Pier Luca Guarino Mentore Ribolsi | 2013 | World Journal of Gastroenterology2013，19，39： | 38 |
| 2 | Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up显示文摘AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal. | Renato Caviglia Mentore Ribolsi Marina Rizzi Sara Emerenziani Maria Laura Annunziata Michele Cicala | 2007 | World Journal of Gastroenterology2007，13，39： | 14 |
| 3 | Regional oesophageal sensitivity to acid and weakly acidic reflux in patients with non-erosive reflux disease 显示文摘 | Emerenziani S Ribolsi M Sifrim D | 2009 | Neurogastroenterol Motil2009，21，3： | 1 |
| 4 | Regional oesophageal sensitivity to acid and weakly acidic reflux in patients with nonerosive reflux disease显示文摘 | Emerenziani S Ribolsi M Sifrim D | 2009 | Neurogastroenterol Motil2009，21，3： | 1 |
| 5 | Regional oesophageal sensitivity to acid and weakly acidic reflux in patients with non-erosive reflux disease显示文摘 | Emerenziani S Ribolsi M Sifrim D | | 0，，： | 1 |
| 6 | Intercellular space diameters of the oesophageal epithelium in NERD patients= head to head comparison between light and electron microscopy analysis显示文摘 | Ribolsi M Perrone G Caviglia R | 2009 | Dig Liver Dis2009，41，1： | 1 |
| 7 | Abnormal brain later- alization and connectivity in schizophrenia 显示文摘 | RIBOLSI M KOCH G MAGNI V | 2009 | Rev Neurosci2009，20，1： | 1 |
| 8 | Dilated in-tercellular spaces of esophageal epithelium in nonero-sive reflux disease patients with physiological esopha-geal acid exposure显示文摘 | Caviglia R Ribolsi M Maggiano N | 2005 | Am J Gastroenterol2005，100，： | 1 |
| 9 | Regional oesophageal sensitivity to acid and weakly acidic reflux in patients with non-erosive reflux disease 显示文摘 | Emerenziani S Ribolsi M Sifrim D | 2009 | Neurogastroenterol Motil2009，21，3： | 1 |
| 10 | Increased frequency and enhanced perception of reflux in non-erosive reflux disease patients non-responders to proton pump inhibitors显示文摘 | Mentore Ribolsi Sara Emerenziani Tommasangelo Petitti Maria Chiara Addarii Paola Balestrieri Michele Cicala | 2012 | Digestive and Liver Disease2012，，7： | 1 |
| 11 | Oesophageal mucosal intercellular space diameter and reflux pattern in childhood erosive and non-erosive reflux disease显示文摘 | Valentina Mancini Mentore Ribolsi Massimo Gentile Gianluigi de’Angelis Barbara Bizzarri Keith J. Lindley Salvatore Cucchiara Michele Cicala Osvaldo Borrelli | 2012 | Digestive and Liver Disease2012，，12： | 1 |
| 12 | Dilated intercellular spaces and acid reflux at the distal and proximal oesophagus in patients with non-erosive gasreo-oesophageal reflux disease显示文摘 | Caviglia R Ribolsi M Gentile M | 2007 | Aliment Pharmacol Ther2007，25，5： | 1 |
| 13 | Abnormal brain lateralization and connectivity in schizophrenia显示文摘 | Ribolsi M Koch G Magni V | 2009 | Rev Neurosci2009，20，1： | 1 |
| 14 | Dilated intercel-lular spaces of esophageal epithelium in nonerosive refluxdisease patients with physiological esophageal acid expo-sure显示文摘 | Caviglia R Ribolsi M Maggiano N | 2005 | Am J Gastroenterol2005，100，3： | 1 |
| 15 | Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure 显示文摘 | Caviglia R Ribolsi M Maggiano N | 2005 | Am J Gastroenterol2005，100，： | 1 |
| 16 | 显示文摘 | Caviglia R Ribolsi M Maggiano N | 2005 | Am J Gastroenterol2005，100，3： | 1 |
| 17 | Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure显示文摘 | Caviglia R Ribolsi M Maggiano N | 2005 | Am J Gastroenterol2005，100，： | 1 |
| 18 | Intercellular space diameters of the oesophageal epithelium in NERD patients : head to head compari- son between light and electron microscopy anMysis 显示文摘 | Ribolsi M Perrone G Caviglia R | 2009 | Dig Liver Dis2009，41，1： | 1 |
| 19 | Increased frequency and enhanced perception of reflux in non-erosive reflux disease patients non-responders to proton pump inhibitors显示文摘 | Mentore Ribolsi Sara Emerenziani Tommasangelo Petitti Maria Chiara Addarii Paola Balestrieri Michele Cicala | 2012 | Digestive and Liver Disease2012，，7： | 1 |
| 20 | Dilated interceLl ularspaces esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure 显示文摘 | CAVIGLIA R RIBOLSI M | 2005 | Am J Gastroenterol2005，100，3： | 1 |
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