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| 1 | Evaluation of latent links between irritable bowel syndrome and sleep quality显示文摘AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study.Data on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson's correlation and Fisher's exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary model.Indeed,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary model.Age was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older patients.Higher daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep disturbances.CONCLUSION:The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. | Massimo Bellini Angelo Gemignani Dario Gambaccini Simona Toti Danilo Menicucci Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Remo Bedini Nicola de Bortoli Santino Marchi | 2011 | World Journal of Gastroenterology2011，17，46： | 17 |
| 2 | How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related?显示文摘AIM:To investigate the prevalence of gastroesophageal reflux disease(GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux(LPR).METHODS:Between May 2011 and October 2011,41 consecutive patients with laryngopharyngeal symptoms(LPS) and laryngoscopic diagnosis of LPR were empirically treated with proton pump inhibitors(PPIs) for at least 8 wk,and the therapeutic outcome was assessed through validated questionnaires(GERD impact scale,GIS;visual analogue scale,VAS).LPR diagnosis was performed by ear,nose and throat specialists using the reflux finding score(RFS) and reflux symptom index(RSI).After a 16-d wash-out from PPIs,all patients underwent an upper endoscopy,stationary esophageal manometry,24-h multichannel intraluminal impedance and pH(MII-pH) esophageal monitoring.A positive correlation between LPR diagnosis and GERD was supposed based on the presence of esophagitis(ERD),pathological acid exposure time(AET) in the absence of esophageal erosions(NERD),and a positive correlation between symptoms and refluxes(hypersensitive esophagus,HE).RESULTS:The male/female ratio was 0.52(14/27),the mean age ± SD was 51.5 ± 12.7 years,and the mean body mass index was 25.7 ± 3.4 kg/m 2.All subjects reported one or more LPS.Twenty-five out of 41 patients also had typical GERD symptoms(heartburn and/or regurgitation).The most frequent laryngoscopic findings were posterior laryngeal hyperemia(38/41),linear indentation in the medial edge of the vocal fold(31/41),vocal fold nodules(6/41) and diffuse infraglottic oedema(25/41).The GIS analysis showed that 10/41 patients reported symptom relief with PPI therapy(P < 0.05);conversely,23/41 did not report any clinical improvement.At the same time,the VAS analysis showed a significant reduction in typical GERD symptoms after PPI therapy(P < 0.001).A significant reduction in LPS symptoms.On the other hand,such result was not recorded for LPS.Esophagitis was detected in 2/41 patients,and ineffective esophageal motility was found in 3/41 patients.The MII-pH analysis showed an abnormal AET in 5/41 patients(2 ERD and 3 NERD);11/41 patients had a normal AET and a positive association between symptoms and refluxes(HE),and 25/41 patients had a normal AET and a negative association between symptoms and refluxes(no GERD patients).It is noteworthy that HE patients had a positive association with typical GERD-related symptoms.Gas refluxes were found more frequently in patients with globus(29.7 ± 3.6) and hoarseness(21.5 ± 7.4) than in patients with heartburn or regurgitation(7.8 ± 6.2).Gas refluxes were positively associated with extraesophageal symptoms(P < 0.05).Overall,no differences were found among the three groups of patients in terms of the frequency of laryngeal signs.The proximal reflux was abnormal in patients with ERD/NERD only.The differences observed by means of MII-pH analysis among the three subgroups of patients(ERD/NERD,HE,no GERD) were not demonstrated with the RSI and RFS.Moreover,only the number of gas refluxes was found to have a significant association with the RFS(P = 0.028 andP = 0.026,nominal and numerical correlation,respectively).CONCLUSION:MII-pH analysis confirmed GERD diagnosis in less than 40% of patients with previous diagnosis of LPR,most likely because of the low specificity of the laryngoscopic findings. | Nicola de Bortoli Andrea Nacci Edoardo Savarino Irene Martinucci Massimo Bellini Bruno Fattori Linda Ceccarelli Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Vincenzo Savarino Stefano Berrettini Santino Marchi | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 3 | Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding显示文摘Chronic intestinal pseudo-obstruction (CIP) is an infre-quent complication of an active systemic lupus erythema-tosus (SLE). We illustrate a case of SLE inactive-related CIP. A 51-year old female with inactive SLE (ECLAM score 2) was hospitalized with postprandial fullness, vomiting, abdominal bloating and abdominal pain. She had had no bowel movements for five days. Plain abdominal X-ray revealed multiple fluid levels and dilated small and large bowel loops with air-fluid levels. Intestinal contrast radiology detected dilated loops. CIP was diagnosed. The patient was treated with prokinetics, octreotide, claritromycin, rifaximin, azathioprine and tegaserod without any clinical improvement. Then methylprednisolone (500 mg iv daily) was started. After the first administration, the patient showed peristaltic movements. A bowel movement was reported after the second administration. A plain abdominal X-ray revealed no air-fluid levels. Steroid therapy was slowly reduced with complete resolution of the symptoms. The patient is still in a good clinical condition. SLE-related CIP is generally reported as a complication of an active disease. In our case, CIP was the only clinical demonstration of the SLE. | Giulia Leonardi Nicola de Bortoli Massimo Bellini Maria Gloria Mumolo Francesco Costa Angelo Ricchiuti Stefano Bombardieri Santino Marchi | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，6： | 3 |
| 4 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 5 | Gastrointestinal manifestations in myotonic muscular dystrophy显示文摘Myotonic (MD ) 被肌强直的现象和进步肌肉发达的软弱描绘。胃肠道的参与是经常的并且可以发生在任何水平。临床的表明以前被归因于改变的平滑肌损坏,而是 histologic 证据引起的活动性混乱少见、冲突。一个神经因素也被假设了。,在更低的道在上面的消化道,咽下困难,心痛,流回和消化不良是最普通的抱怨,腹的疼痛,膨胀并且在肠习惯的变化经常被报导。消化症状可以是营养不良的疾病的第一症状并且可以先于肌与骨的特征。胃肠的功能的缺陷可能有时是那么渐渐的病人与症状的很少了解适应它。不在内视镜的如此的情况常规和 ultrasonographic 评估是足够、指向的技术(胃电描记法,测压法,肌电描记法,功能的 ultrasonography, scintigraphy,等等) 被需要。而与骨胳的肌肉疾病的持续时间的积极关联被报导了,在胃肠的骚乱的骨胳的肌肉参与和存在和严厉的度之间有低关联。这些药为对待象专业版那样的胃肠的抱怨推荐了运动的、反消化不良的药和 laxatives,主要针对改正活动性混乱。自从许多重要问题仍然是未解决的,在 MD 的胃肠的参与仍然是一个复杂、吸引人的条件。专注于基因方面,早诊断的技术和新治疗学的策略的发展的进一步的研究被需要改进我们 MD 的胃肠的表明的管理。 | Massimo Bellini Sonia Biagi Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Santino Marchi | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 6 | Cardiac troponin Ⅰ and T alterations in dog hearts with myocardial infarction:correlation with infarct size显示文摘 | Sharkey S W Murakami M M | 1998 | Am J Clin Pathol1998，110，： | 1 |
| 7 | Estradiol increases angiotensin Ⅱ type 1 receptor in hearts of ovariectomized rats显示文摘 | Ricchiuti V Lian CG Oestreicher EM | 2009 | J Endocrinol2009，200，1： | 1 |
| 8 | Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin,peroxisome proliferator-activated receptor- , and proinflammatory adipokines 显示文摘 | Guo C Ricchiuti V Lian BQ | 2008 | Circulation2008，117，17： | 1 |
| 9 | Mineralocorticoid recep-tor blockade reverses obesity-related changes in expression of adiponectin,peroxisome proliferator-activated receptor-gamma,and proinflammatory adipokines显示文摘 | Guo C Ricchiuti V Lian BQ | | 0，，17： | 1 |
| 10 | Staged ret-rograde endoscopic lithotripsy as alternative to PCNL in selectpatients with large renal calculi显示文摘 | Ricchiuti D J Smaldone M C Jacobs B L | 2007 | J Endourol2007，21，12： | 1 |
| 11 | Inflammation and Hypertension:The Interplay of Interleukin-6,Dietary Sodium,and the Renin–Angiotensin System in Humans显示文摘 | Chamarthi B Williams GH Ricchiuti V | 2011 | American Journal of Hypertension2011，24，： | 1 |
| 12 | Use of arterial conduit as an alternative technique in arterial revascularization during orthotopic liver transplantation 显示文摘 | Zamboni F Franchello A Ricchiuti A | 2002 | Dig Liver Dis2002，34，2： | 1 |
| 13 | Laparoscopic repair of a trau-matic bladder rupture显示文摘 | Marchand TD Cuadra RH Ricchiuti DJ | 2012 | JSLS2012，16，1： | 1 |
| 14 | Monitoring Plasma Cardiac Troponin I for the Detection of Myocardial Injury after Percutaneous Transluminal Coronary Angioplasty 显示文摘 | Ricchiuti V Shear W S Henry T D | 2000 | Clinica Chimica Acta2000，302，12： | 1 |
| 15 | 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block显示文摘 | Fritsch C Hoebeke J Dali H Ricchiuti V Isenberg DA Meyer O | 2006 | Arthritis Res Ther2006，8，1： | 1 |
| 16 | Power supply decoupling on fully populated high-speed digital PCBs 显示文摘 | Ricchiuti V | 2001 | IEEE Trans Electromagn Compat2001，43，4： | 1 |
| 17 | Power bus signal integrity improvement and EMI mitigation on multilayer high-speed digital PCBs with embedded capacitance显示文摘 | Vittorio Ricchiuti | 2003 | IEEE Transaction on Mobile Computing2003，2，4： | 1 |
| 18 | Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin,peroxisome proliferator-activated receptor-gamma,and proinflammatory adipokines显示文摘 | Guo C Ricchiuti V Lian BQ | | 0，，： | 1 |
| 19 | Cardiac troponin Ⅰ and T alterations in hearts with severe left ventricular remodeling显示文摘 | Ricchiuti V Zhang J Apple FS | 1997 | Clin Chem1997，43，61： | 1 |
| 20 | Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adipone- ctin,peroxisome proliferator-activated receptor-gamma, and proin- flammatory adipokines 显示文摘 | Guo C Ricchiuti V Lian BQ | 2008 | Circulation2008，117，17： | 1 |
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