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| 1 | Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms显示文摘It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness.However,the collective effects of SNPs have yet to be examined by experimental science.We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations.We identified the minor alleles(MAs)in each panel and the MA content(MAC)that each inbred strain carried for a set of SNPs with genotypes determined in these panels.MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms,including life span,tumor susceptibility,learning and memory,sensitivity to alcohol and anti-psychotic drugs,and two correlated traits poor reproductive fitness and strong immunity.These results suggest that the collective effects of SNPs are functional and do affect reproductive fitness. | YUAN DeJian ZHU ZuoBin TAN XiaoHua LIANG Jie ZENG Chen ZHANG JieGen CHEN Jun MA Long DOGAN Ayca BROCKMANN Gudrun GOLDMANN Oliver MEDINA Eva RICE Amanda D. MOYER Richard W. MAN Xian YI Ke LI YanKe LU Qing HUANG YiMin HUANG Shi | 2014 | Science China(Life Sciences)2014，57，9： | 2 |
| 2 | Real-time PCR with molecular beacons provides a highly accurate assay for detection of Tay-Sachs alleles in single cells显示文摘 | Rice JE Sanchez JA Pierce KE | 2002 | Prenat Diagn2002，22，12： | 1 |
| 3 | Detection of cystic fibrosis alleles from single cells using molecular beacons and a novel method of asymmetric real-time PCR显示文摘 | Pierce KE Rice JE Sanchez JA | 2003 | Mol Hum Reprod2003，9，12： | 1 |
| 4 | Etiology, diagnosis, and man- agement of uterine leiomyomas 显示文摘 | Rice KE Secrist J Woodrow E | 2012 | J Midwifery Women Health2012，57，3： | 1 |
| 5 | Comparison of cell lysis conditions for single cell PCR using molecular beacons to monitor reactions in real time显示文摘 | Rice JE Sanchez JA | 1999 | Fertil Steril1999，72，： | 1 |
| 6 | Marked suppres-sion of gastric ulcerogenesis and intestinal responses to stressby a novel class of drugs 显示文摘 | Gabry KE Chrousos GP Rice KC | 2002 | Mo] Psychiatry2002，7，： | 1 |
| 7 | Etiology, diagnosis, and management of uterine leiomyomas 显示文摘 | Rice KE Secrist JR Woodrow EL | 2012 | J Midwifery Womens Health2012，57，3： | 1 |
| 8 | Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties显示文摘 | Reed KE Rice CM | 2000 | Curt Top Micro-biol Immunol2000，242，： | 1 |
| 9 | Etiology, diagnosis, and management of uterine leiomyomas显示文摘 | Rice KE Secrist JR Woodrow EL | 2012 | J Midwifery Womens Health2012，57，3： | 1 |
| 10 | Real-time PCR using molecular beacons for accurate detection of the Y chromosome in single human blastomeres显示文摘 | Pierce KE Rice JE Aquiles Sanchez J | 2000 | Mol Hum Reprod2000，6，： | 1 |
| 11 | Etiology, diagno-sis, and management of uterine leiomyomas 显示文摘 | Rice KE Secrist JR Woodrow EL | 2012 | J Mid- wifery Womens Health2012，57，3： | 1 |
| 12 | Etiology, diagnosis, and man- agement of uterine leiomyomas 显示文摘 | Rice KE Secrist JR Woodrow EL | 2012 | J Midwifery Womens Health2012，57，3： | 1 |
| 13 | QuantiLyse: reliable DNA amplification from single cells显示文摘 | Pierce KE Rice JE Sanchez JA | 2002 | Biotechniques2002，32，5： | 1 |
| 14 | Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties 显示文摘 | Reed KE Rice CM | 2000 | Curt Top Microbiol Immunol2000，242，： | 1 |
| 15 | Immunohistochemical localization of histamine H3receptors in rodent skin,dorsal root ganglia,superior cervical ganglia,and spinal cord:potential antinociceptive targets显示文摘 | Cannon KE Chazot PL Hann V Shenton F Hough LB Rice FL | 2007 | Pain2007，129，102： | 1 |
| 16 | Overview of hepatitis C virus genome struc-ture, polyprotein processing, and protein properties 显示文摘 | Reed KE Rice CM | 2000 | Curt Top Microbiol immunol2000，242，： | 1 |
| 17 | Real-time PCR using molecular beacons for accurate detection of the Y chromosome in single human blastomeres显示文摘 | Pierce KE Rice JE Sanchez JA | 2000 | Mol Hum Reprod2000，6，12： | 1 |
| 18 | Etiology,diagnosis,and management of uterine leiomyomas 显示文摘 | Rice KE Seerist J Woodrow E | 2012 | Journal of Midwifery dr Women'' s Health2012，57，3： | 1 |
| 19 | Real-time PCR using molecular beacons for accurate detection of the Y chromosome in single human blastomeres显示文摘 | Pierce KE Rice JE Sanchez JA | 2000 | Mol Hum Reprod2000，6，： | 1 |
| 20 | Overview of hepatitis C virus genome structure,polyprotein processing,and protein properties显示文摘 | Rice CM | 2000 | Curr Top Microbiol Immunol2000，242，： | 1 |
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