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| 1 | Colorectal cancer of the young displays distinct features of aggressive tumor biology:A single-center cohort study显示文摘BACKGROUND In recent years,a decrease in incidence and mortality of colorectal cancer(CRC)has been observed in developed nations,presumably through public disease awareness and increased screening efforts.However,a rising incidence of CRC in young patients below the age of 50 years has been reported in several studies.AIM To study tumor biology in CRC patients below 50 years of age.METHODS All patients with CRC were prospectively enrolled in our single-center oncologic database from January 2013 to December 2018 and were grouped and analyzed according to age(≥50 and<50 years).Clinical as well as histopathological features were analyzed and compared.The study was approved by the local Ethics Committee.Fisher’s exact test or t-test was used to test for differences between the groups,as appropriate.All statistical analysis was performed with IBM SPSS software Version 25(SPSS Inc,Armonk,NY,United States)and with RStudio using R Version 3.4.1(RStudio,Boston,MA,United States).RESULTS Seventeen percent of the 411 patients were younger than 50 years.Young patients were more often diagnosed with locally advanced T4-tumors and lymph node metastases(36.6%and 62%vs 17.7%and 42%;P<0.01).In addition,a higher frequency of poorly differentiated(G3)tumors(40%vs 22.4%P<0.05)was observed.More than every second patient below 40 years of age(51.8%)had distant metastases at diagnosis with a significant higher rate ring of signet cell differentiation compared to patients≥50 years(14.8%,P<0.05).Mutational status(KRAS,NRAS,BRAF,MSI)as well as selected behavioral risk factors showed no significant differences.CONCLUSION Distinct histopathologic features of increased biologic aggressiveness are found in patients with CRC of young-onset.Those patients present more frequently with more advanced tumor stages compared to older patients.Features of aggressive tumor biology underscore the need for earlier uptake of routine screening measures. | Matteo Mueller Marcel Andre Schneider Barla Deplazes Daniela Cabalzar-Wondberg Andreas Rickenbacher Matthias Turina | 2021 | World Journal of Gastrointestinal Surgery2021，13，2： | 3 |
| 2 | N - terminal pro brain natriuretic peptide - guided management in patients with heart failure and preserved ejection fraction: findings from the Trial of Intensified versus standard medical therapy in elderly patients with congestive heart failure (TIME - CHF) 显示文摘 | MAEDER M T RICKENBACHER P RICKI H | 2013 | Eur J Heart Fail2013，15，10： | 1 |
| 3 | Algorithmic models of interference in wireless Ad hoc and sensor networks显示文摘 | VON RICKENBACH P WATTENHOFER R ZOLLINGER A | 2009 | IEEE/ACM Trans on Networking2009，17，1： | 1 |
| 4 | Systematic evaluation of surgical strategies for acute malignant left-sided colonic obstruction显示文摘 | Breitenstein S Rickenbacher A Berdajs D | 2007 | Br J Surg2007，94，12： | 1 |
| 5 | Incidence and severity of transplant coronary artery disease early and up to 15 years after transplantation as detected by intravascular ultrasound显示文摘 | Rickenbacher PR Pinto FJ Chenzbraun A | 1995 | J Am Coll Cardiol1995，25，1： | 1 |
| 6 | Association between two distinct executive tasks in schizophrenia: Functional transcranial Doppler sonography study 显示文摘 | Feldmann D Schuepbach D yon Rickenbach B | 2006 | BMC Psychiatry2006，6，： | 1 |
| 7 | Late Clinical Events After Clopidogrel Discontinuation May Limit the Benefit of Drug-Eluting Stents显示文摘 | Matthias Pfisterer Hans Peter Brunner-La Rocca Peter T. Buser Peter Rickenbacher Patrick Hunziker Christian Mueller Raban Jeger Franziska Bader Stefan Osswald Christoph Kaiser | 2006 | Journal of the American College of Cardiology2006，，12： | 1 |
| 8 | System- atic evaluation of surgical strategies for acute malignant left-sided colonic obstruction 显示文摘 | Breitenstein S Rickenbacher A Berdajs D | 2007 | Br J Surg2007，94，12： | 1 |
| 9 | Decreasing mortality and changing patterns of causes of death in the S wiss HIV C ohort S tudy显示文摘 | R Weber M Ruppik M Rickenbach A Spoerri H Furrer M Battegay M Cavassini A Calmy E Bernasconi P Schmid M Flepp J Kowalska B Ledergerber | 2012 | HIV Med2012，，4： | 1 |
| 10 | Non-Hodgkin Lymphoma incidence in the Swiss HIV Cohort Study before and after highly active an- tiretmviral therapy 显示文摘 | Polesel J Clifford GM Rickenbach M | 2008 | AIDS2008，22，2： | 1 |
| 11 | A multicenter randomized clinical trial of primary anastomosis or Hartmann's procedure for perforated left colonic diverticulitis with purulent or fecal peritonitis显示文摘 | Oberkofler CE Rickenbacher A Raptis DA | 2012 | Ann Surg2012，256，： | 1 |
| 12 | Systematic evaluation of surgical strategies for acute malignant left-sided colonic obstruction显示文摘 | Breitenstein S Rickenbacher A Berdajs D | | 0，，12： | 1 |
| 13 | Systematic evaluation of surgical strategies for acute malignant left-sided colonic obstruction 显示文摘 | Breitenstein S Rickenbacher A Berdajs D | 2007 | Br J Surg2007，94，12： | 1 |
| 14 | Chemotherapy before liver resection of colorectal metastases: tiiend or foe? 显示文摘 | Lehmann K Rickenbacher A Weber A | 2012 | AnnSurg2012，255，2： | 1 |
| 15 | Trends in cardiovascular risk factors (1984- 1993) in a Swiss region: results of three population surveys显示文摘 | Wietlisbach V Paccaud F Rickenbach M | 1997 | Preventive Medicine1997，26，4： | 1 |
| 16 | Systematic e- valuation of surgical strategies for acute malignant left-sided colonic obstruction 显示文摘 | Breitenstein S Rickenbacher A Berdajs D | 2007 | BrJ Surg2007，94，12： | 1 |
| 17 | Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells显示文摘 | Hammar EB Irminger JC Rickenbach K | 2005 | J Biol Chem2005，280，30： | 1 |
| 18 | Algo- rithmic models of interference in wireless ad hoe and sensor net- works显示文摘 | RICKENBACH P V WATTENHOFER R ZOLLINGER A | 2009 | IEEE/ACM Transactions on Networking2009，17，1： | 1 |
| 19 | Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration 显示文摘 | Lehmann K Tschuor C Rickenbacher A | 2012 | Gastroenterology2012，143，6： | 1 |
| 20 | Forest certification of small ownerships-- some practical challenges 显示文摘 | RICKENBACH M G | 2002 | Journal of Forestry2002，100，6： | 1 |
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