|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Feasibility of transure- thral resection for muscle infiltrating carcinoma of the blad der~long-term follow-up of a prospective study显示文摘 | Solsona E Iborra L Ricos J | 1998 | J Urol1998，159，： | 1 |
| 3 | Wetting angles and photocatalytic activities of illuminated TiO2 thin films 显示文摘 | V Rico P Romero J L Hueso | 2009 | Catalysis Today2009，143，： | 1 |
| 4 | Characterisation of solid and liquid fractions of dairy manure with regard to their component distribution and methane production显示文摘 | Rico J L Garcia H Rico C | 2007 | Bioresource Technology2007，98，： | 1 |
| 5 | Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells显示文摘 | Gonzalez MA Gonzalez-Rey E Rico L | 2009 | Arthritis Rheum2009，60，4： | 1 |
| 6 | The Anti-epileptic Drug Levetiracetam Reverses the Inhibition by Negative Allosteric Modulators of Neuronal GABA-and Glycine-gated Currents显示文摘 | Rico JM Hans G Nguyen L | 2002 | Br J Pharmacol(S0007-1188)2002，136，5： | 1 |
| 7 | Acute myelogenous leukemia stem cells: from Bench to Bedside 显示文摘 | FELIPE RICO J HASSANE DC GUZMAN M L | 2013 | Cancer Lett2013，338，1： | 1 |
| 8 | Approximate cost of theelimination of boron in desalinated water by reverse osmosis andion exchange resins显示文摘 | Ariasd M F C Bru L V Rico D P | 2011 | Desalination2011，273，23： | 1 |
| 9 | Phenolic composition of skins from four Carmenet grape varieties ( Vitis vinifera L.) during ripening显示文摘 | Elías Obreque-Slier álvaro Pe?a-Neira Remigio López-Solís Alejandro Cáceres-Mella Héctor Toledo-Araya Américo López-Rivera | 2013 | LWT - Food Science and Technology2013，，： | 1 |
| 10 | Enhanced pho- toactivity for the phenol mineralization on ZnA1La mixed oxides prepared from calcined LDHs 显示文摘 | TZOMPANTZI F DAMIAN G M RICO J L | 2014 | Catalysis Today2014，22，： | 1 |
| 11 | Biosorption of hexavalent chromium from aqueous solution by Sargassum muticum brown alga: application of statistical design for process optimization 显示文摘 | BERMUDEZ Y G RICO I L R GUIBAL E | 2012 | Chemical Engineering Journal2012，183，： | 1 |
| 12 | A more general mobility criterion for parallel platforms显示文摘 | RICO J M AGUILERA L D | 2006 | ASME Journal of Mechanical Design2006，128，： | 1 |
| 13 | Treatment of experimen-tal arthritis by inducing immune tolerance with human adipose-de-rived mesenchymal stem cells显示文摘 | Gonzalez MA Gonzalez-Rey E Rico L | 2009 | Arthritis Rheum2009，60，4： | 1 |
| 14 | Adipose-derived mesenehymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses 显示文摘 | Gonzalez MA Gonzalez-Rey E Rico L | 2009 | Gastroenterology2009，136，3： | 1 |
| 15 | Removal of carbon dioxide from a breating gas mixtures using a hollow-fiber permeator with purge and absorption 显示文摘 | Li L Chen Y rico K W | 1995 | Gas Separation and Purification1995，9，2： | 1 |
| 16 | Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients显示文摘 | Leung J M Sands L P Rico M | 2006 | Neurology2006，67，7： | 1 |
| 17 | Predicting Fluid Responsiveness in Patients Undergoing Orthotopic Liver Transplantation: Effects on Intraoperative Blood Transfusion and Postoperative Complications显示文摘 | N. Lekerika R.M. Gutiérrez Rico J. Arco Vázquez L. Prieto Molano E. Arana-Arri L. Martínez Indart A. Martínez Ruiz J. Ortiz de Urbina López | 2014 | Transplantation Proceedings2014，，9： | 1 |
| 18 | Preliminary investigation onthe relationship of Raman spectra of sheep meat with shear forceand cooking loss显示文摘 | Heinar S Rico S David L H | 2013 | Meat Science2013，93，1： | 1 |
| 19 | Design and synthesis of a novel class of histone deacetylase inhibitors显示文摘 | Rico L Giliane B Sylvie F | 2001 | Bioorg Med Chem Lett2001，11，21： | 1 |
| 20 | Concise review: bone marrow mononuclear cells for the treatment of ischemic syndromes: medicinal product or cell transplantation? 显示文摘 | Cuende N Rico L Herrera C | 2012 | Stem Cells Transl Med2012，1，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员