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| 1 | Isolated limb infusion chemotherapy with or without hemofiltration for recurrent limb melanoma显示文摘AIM: To better define the efficacy and the safety of intra-arterial infusion performed with or without hemofiltration for recurrent limb melanoma. METHODS: Patients with the following characteristics were included in the study: recurrent limb melanoma not indicated for surgical resection, measurable disease in the extremity, > 18 years, performances status(Eastern Cooperative Oncology Group) was 0-1 and life expectancy of at least 6 mo. Twenty nine consecutive patients were enrolled in the study. Patients underwent fluoroscopic placement of angiographic arterial and venous catheters to infuse the drug in the artery [isolated limb infusion(ILI)], and to stop the out flow(venous). Melphalan was rapidly infused into the isolated limb via the arterial catheter after the inflation of venous balloon catheter. Then the circulation of the limb was completely blocked with a pneumatic cuff at the root of the limb. Haemofiltration(HF) was available only in the main center, and was performed with an extracorporeal perfusion system, in order to reduce high systemic toxic peaks of drug.RESULTS: Thirty seven ILI were done in 29 cases(31 ILI-HF and 6 ILI) between 2001 and 2014 at Ancona and Pesaro Hospitals, Italy. Clinical outcomes were monitored 30 d after treatment. Eleven patients(38%) received infusion of melphalan alone, 7(24%) melphalan associated to mitomicin C and 7(24%) melphalan associated to cisplatin, the remaining 4 were treated with cisplatin, melphalan and epirubicin or cisplatin and mitomicin C. The overall response rate was 66%, in particular, 3 patients(10%) were complete responders and 16(56%) were partial responders; whereas 7 patients(24%) had stable disease, and 3(10%) showed progressive disease. Limb toxicity was assessed adopting Wieberdink scale, with evidence of 90% of low grade(I and II) toxicity.CONCLUSION: ILI-HF and ILI are effective and safe treatments for recurrent non-resectable limb melanoma. They present evidence of favorable clinical benefit and is effective in delaying progression. | Sara Cecchini Donatella Sarti Stefano Ricci Ludovico Delle Vergini Manuela Sallei Stefano Serresi Giuseppe Ricotti Luca Mulazzani Fabrizia Lattanzio Giammaria Fiorentini | 2015 | World Journal of Clinical Oncology2015，6，4： | 2 |
| 2 | In vitro schedualdependent interaction between docetaxel and gemcitabine in human gastric cancer cell lines显示文摘 | Ricotti L Tesei A Frassineti GL | 2003 | PClin Cancer Res2003，9，： | 1 |
| 3 | Two-phase pressure drops in a helically coiled steam generator显示文摘 | Lorenzo Santini Andrea Cioncolini Carlo Lombardi Marco Ricotti | 2008 | International Journal of Heat and Mass Transfer2008，，19： | 1 |
| 4 | Chitosan and gelatin as engineered dressing for wound repair显示文摘 | Ricotti G Mattioli-Belmonte M | 2001 | Journal of Bioactive and Compatible Polymers(English)2001，16，2： | 1 |
| 5 | Pediatric obesity and vitamin D deficiency:a proteomic approach identifies muhimeric adiponectin as a key link between these conditions 显示文摘 | Walker GE Ricotti R Roccio M | 2014 | PLoS One2014，9，83： | 1 |
| 6 | Docetaxel and gemcit- abine activity in NSCI~C cell lines and in primary cultures from human lung cancer显示文摘 | Zoli W Ricotti L Dal Susino M | 1999 | Br J Cancer1999，81，4： | 1 |
| 7 | Microscopic and physi-ologic evidence for biofilm-associated wound colonization in vivo 显示文摘 | Davis SC Ricotti C Cazzaniga A | 2008 | Wound Repair Regen2008，16，1： | 1 |
| 8 | In vitro schedule-dependent interactions between the muhitargeted antifolate LY231514 and gemcitabine in human colon denocarcinoma cell lines 显示文摘 | Tesei A Ricotti L De Paola F | 2002 | Clin Cancer Res2002，8，1： | 1 |
| 9 | Deter- mination of hydroxyl free radical formation in human platelets using high-performance liquid chromatography with electrochemical detection显示文摘 | BLANDINI F MARTIGNONI E RICOTTI R | 1999 | Journal of Chroma- tography B1999，732，： | 1 |
| 10 | In vitro schedule-dependent interaction between docetaxel and gemcitabine in human gastric cancer cell lines 显示文摘 | Ricotti L Tesei A De Paola F | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 11 | Study of metal protective hydrophobic coatings from waterborne polyurethane ionomers 显示文摘 | Delucchi M Trombetta T Ricotti R | 2009 | Journal of Applied Electrochemistry2009，39，： | 1 |
| 12 | Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds 显示文摘 | RICOTTI L POLINI A GENCHI G G | 2012 | Biomed Mater2012，7，03： | 1 |
| 13 | Neural network approach to sensitivity and uncertainty analysis显示文摘 | Ricotti M E Zio E | 1999 | Reliability Engineering and Sys- tem Safety1999，64，1： | 1 |
| 14 | Evaluation of erosion-corrosion in multiphase flow via CFD and experimental analysis 显示文摘 | Bozzini B Ricotti M E Boniardi M | 2003 | Wear2003，255，： | 1 |
| 15 | Evaluation of Erosion-Corrosion in Multiphase Flow via CFD and Experimental Analysis显示文摘 | Bozzini Benedetto Ricotti Marco E | 2003 | Wear2003，255，1： | 1 |
| 16 | Docetaxel and gemictabine activity in NSCLC cell lines and in primary cultures from human lung cancer显示文摘 | Ricotti L Dal Susino M | 1999 | Br J Cancer1999，81，4： | 1 |
| 17 | Jr Laser-assisted tattoo removal with topical 5% imiquimod cream显示文摘 | Ricotti CA Colaco SM Shamma HN | 2007 | Dermatol Surg2007，33，9： | 1 |
| 18 | Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo显示文摘 | Davis SC Ricotti C Cazzaniga A | 2008 | Wound Repair Regen2008，16，1： | 1 |
| 19 | Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy 显示文摘 | Schwartzberg JB Ricotti CA Jr Ballard CJ | 2007 | Int J Dermatol2007，46，2： | 1 |
| 20 | CIM +/CD56 + Hematodermic neoplasm (plasmacytoid dendritic cell tumor 显示文摘 | Shiman M Marchione R Ricotti C el al | 2008 | Dermatol Online J2008，14，11： | 1 |
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