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| 1 | 北京友谊医院1998~2001年轮状病毒哨点监测分析显示文摘目的 了解 5岁以下儿童中以医院为基础的轮状病毒流行情况。方法 按WHO轮状病毒监测的通用方法 (CID 98)进行 ,轮状病毒检测采用聚丙烯酰胺凝胶电泳 /酶联免疫吸附试验(ELISA)。毒株分型用ELISA/逆转录聚合酶链反应。结果 从 1998年 4月至 2 0 0 1年 3月收集的4 84份腹泻患儿粪便标本中 ,检出阳性标本 12 3份 ,总的轮状病毒感染检出率为 2 5 .4 % ,住院和门诊患儿检出率分别是 31.6 %和 2 7.3% ,而在轮状病毒流行季节 ,则可以引起高达 4 6 .2 %急性腹泻住院率。腹泻患儿发病呈现两个明显的季节高峰 :一个由细菌性痢疾引起的夏季 (6~ 9月 )发病高峰 ,另一个是轮状病毒感染腹泻造成的秋冬季 (10~ 12月 )发病高峰。轮状病毒感染 96 .8%发生于 3岁以下幼儿 ,主要在 6~ 11月龄 (38.2 % )和 1~ 2岁 (2 8.5 % )年龄组 ,轮状病毒感染率在 6~ 35月龄年龄段最高。流行的轮状病毒G血清型依次为G1(5 5 .3% )、G2 (2 6 .8% )、G3(9.8% )和G4 (0 .8% ) ,没有发现G9型 ,10份 (8.1% )标本未能分型 ,混合感染 (0 .8% )罕见。结论 轮状病毒腹泻是北京市儿童的重要传染病 ,开发应用安全有效的轮状病毒疫苗将对减轻轮状病毒疾病负担有重要作用。 | 童志礼 马莉 章菁 侯安存 郑丽舒 金宗平 谢华萍 马兰 张丽杰 Ivanoff B Glass RI Bresee JS JIANG Xi Kilgore PE 方肇寅 | 2003 | 中华流行病学杂志2003，24，12： | 27 |
| 2 | 长春市儿童医院1998~2001年轮状病毒哨点监测分析显示文摘目的 为在中国开发和应用轮状病毒疫苗提供流行病学背景资料。方法 以医院为基础的哨点监测 ,在长春市儿童医院 5岁以下腹泻患儿中进行 ,收集患儿临床资料和粪便标本 ,轮状病毒检测用聚丙烯酰胺凝胶电泳 (PAGE)和 或酶联免疫吸附试验 (ELISA) ,毒株分型用ELISA和 或逆转录 聚合酶链反应 (RT PCR)。所有资料录入计算机进行数据分析。结果 3年监测中共调查 2 3 4 3例腹泻患儿 ,收集便样 12 11份 ,轮状病毒检出率门诊患儿和住院患儿分别为 3 1.0 %和 52 .9%。轮状病毒感染 95.0 %发生于 2岁以下儿童。每年寒冷季节流行 (11月到次年 3月 )。流行的轮状病毒G血清型依次为G1(82 .4% )、G2 (5.0 % )、G3 (3 .3 % )和G 4(0 .9% ) ,P基因型以P[8]和P[4]为常见。共检出 9种P~G结合的毒株 ,其中世界常见的 4种流行株占 75.6%。结论 轮状病毒流行毒株呈现超常多样性 。 | 孙利炜 童志礼 李丽红 章菁 陈琦 郑丽舒 刘静 谢华萍 王承训 张丽杰 Ivanoff B Glass RI Bresee JS Jiang XI Kilgore PE 方肇寅 | 2003 | 中华流行病学杂志2003，24，11： | 25 |
| 3 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 4 | Differential chaos shift keying: A robust coding for chaos communication显示文摘 | KOLUMBAN G VIZV RI B SCHWARZ W | 1996 | Proc NDES Seville1996，45，8： | 2 |
| 5 | Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications显示文摘 | Alíz Czeglédi Dorina Ujvári Eszter Somogyi Enik? Wehmann Ortrud Werner Béla Lomniczi | 2006 | Virus Research2006，，1： | 2 |
| 6 | Translational mini-review series on TH17 cells: induction of interleukin-17 production by regu- latory T cells显示文摘 | Afzali B Mitehell P Lechler RI | 2010 | Clin Exp Immunol2010，159，2： | 1 |
| 7 | Carbamazepine poisoning:Elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide显示文摘 | Winnicka RI Fopacinski B Szymczak WM | 2002 | Clinical toxicology2002，40，6： | 1 |
| 8 | Pulmonary re-habilitation: Joint ACCP/ A AC VPR evidence-based clin-ical practice guidelines显示文摘 | Ries A L Bauldoff G S Carlin B W | 2007 | Chest2007，131，1： | 1 |
| 9 | GGM02 : an improved earth gravity field model from GRACE显示文摘 | TAPLEY B RIES J BETYADPUR S | 2005 | Journal of Geodesy2005，79，8： | 1 |
| 10 | Study of humic-like substances in fog and interstitial aerosol by size-exclusion chromatography and capillary electrophoresis显示文摘 | Z Krivácsy Gy Kiss B Varga I Galambos Zs Sárvári A Gelencsér á Molnár S Fuzzi M.C Facchini S Zappoli A Andracchio T Alsberg H.C Hansson L Persson | 2000 | Atmospheric Environment2000，，25： | 1 |
| 11 | Estimation of biomass in aneotropical forest of French Guiana:spatial and temporal variability显示文摘 | Chave J Riéra B Dubois M A | 2001 | Journal ofTropical Ecology2001，17，： | 1 |
| 12 | Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes显示文摘 | Ries C Loher F Zang C B | 1999 | Clin Cancer Res1999，5，5： | 1 |
| 13 | Monitoring of gully erosion in the CentralEbro Basin by large-scale aerial photography taken from a re-motely controlled blimp显示文摘 | Ries J B Marzolff I | 2003 | Catena2003，50，24： | 1 |
| 14 | E-commerce recommendation applications显示文摘 | SCHAFER J B KONGSTAN J A RIED J | 2001 | Data Mining and Knowledge Discovery2001，5，12： | 1 |
| 15 | Review: geological and experimental evidence for secular variation in seawater Mg/Ca (calcite-aragonite seas) and its effects on marine biological calcification显示文摘 | Ries J. B | 2010 | Biogeosciences2010，，73： | 1 |
| 16 | CO2-in- duced ocean acidification impairs calcification in the tropical urchin Echinometra viridis显示文摘 | COURTNEY T WESTFIELD I RIES J B | 2013 | Journal of Ex- perimental Marine Biology and Ecology2013，440，1： | 1 |
| 17 | Frequent pro- moter hypermethylation of the O^6 - methylguanine - DNA methyl - transferase ( MGMT ) gene in testicular cancer 显示文摘 | Smith - Sorensen B Lind GE Skotheim RI | 2002 | Oncogene2002，21，57： | 1 |
| 18 | Advanced shape memory alloys processed by powder metallurgy显示文摘 | PI~RI~SAEZ R B RECARTE V N(SM L | 2000 | Advanced Engineering Materials2000，2，12： | 1 |
| 19 | K<sup>+</sup> depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study显示文摘 | A Heinrich RD Andó G Túri B Rózsa B Sperlágh | 2012 | British Journal of Pharmacology2012，，5： | 1 |
| 20 | Pharmacological characterization of the novel nonpeptide angiotensinⅡ receptor antagonist, BIBR 277显示文摘 | Wienen W Hauel N Van Meel JC Narr B Ries U Entzeroth M | 1993 | Br J Pharmacol1993，110，1： | 1 |
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