| 1 | Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy显示文摘Bone marrow mesenchymal stem cells can differentiate into neurons and astrocytes after transplantation in the spinal cord of rats with ischemia/reperfusion injury. Although bone marrow mesenchymal stem cells are known to protect against spinal cord ischemia/reperfusion injury through anti-apoptotic effects, the precise mechanisms remain unclear. In the present study, bone marrow mesenchymal stem cells were cultured and proliferated, then transplanted into rats with ischemia/reperfusion injury via retro-orbital injection. Immunohistochemistry and immunofluorescence with subsequent quantification revealed that the expression of the axonal regeneration marker, growth associated protein-43, and the neuronal marker, microtubule-associated protein 2, significantly increased in rats with bone marrow mesenchymal stem cell transplantation compared with those in rats with spinal cord ischemia/reperfusion injury. Furthermore, the expression of the autophagy marker, microtubule-associated protein light chain 3B, and Beclin 1, was significantly reduced in rats with the bone marrow mesenchymal stem cell transplantation compared with those in rats with spinal cord ischemia/reperfusion injury. Western blot analysis showed that the expression of growth associated protein-43 and neurofilament-H increased but light chain 3B and Beclin 1 decreased in rats with the bone marrow mesenchymal stem cell transplantation. Our results therefore suggest that bone marrow mesenchymal stem cell transplantation promotes neurite growth and regeneration and prevents autophagy. These responses may likely be mechanisms underlying the protective effect of bone marrow mesenchymal stem cells against spinal cord ischemia/reperfusion injury. | Fei Yin Chunyang Meng Rifeng Lu Lei Li Ying Zhang Hao Chen Yonggang Qin Li Guo | 2014 | Neural Regeneration Research2014，9，18： | 16 |
| 2 | Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis显示文摘DearEditor,Indole-3-carboxaldehyde(ICA)is a gut microbe-derived tryptophan metabolite.Here,we explored the role of ICA in atherosclerosis.Plasma tryptophan metabolites were measured in healthy individuals and patients with atherosclerosis(Supplementary Table S1).The latter group showed disturbed tryptophan metabolism,while no difference was observed in tryptophan levels between the two groups(Fig.1a).ICA concentration is lower in the patients group(Fig.1b),consistent with previous clinical studies.1 The concentration of other metabolites of kynurenine or serotonin pathway showed no variations between the control and the patients(Supplementary Fig.1a). | Yijing Lu Wenlong Yang Zhiyong Qi Rifeng Gao Jing Tong Tingwen Gao Yin Zhang Aijun Sun Shuning Zhang Junbo Ge | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
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