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| 1 | Chronic hepatitis C:This and the new era of treatment显示文摘Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This occurred for the availability of direct-acting antiviral agents that allow to reach sustained virologic response in approximately 90% of cases. In the near future further progress will be achieved with the use of pan-genotypic drugs with high efficacy but without side effects. | Gaetano Bertino Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Shirin Demma MariaIrene Ruggeri Laura Scuderi Giulia Malaguarnera Nicoletta Bertino Venerando Rapisarda Isidoro Di Carlo Adriana Toro Federico Salomone Mariano Malaguarnera Emanuele Bertino Michele Malaguarnera | 2016 | World Journal of Hepatology2016，8，2： | 10 |
| 2 | The potential of natural products for targeting PPARα显示文摘Peroxisome proliferator activated receptors(PPARs) α,-γ and-β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia(fibrates, e.g. fenofibrate and gemfibrozil) and diabetes(thiazolidinediones, e.g. rosiglitazone and pioglitazone) are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this 'hot' target. | Daniela Rigano Carmina Sirignano Orazio Taglialatela-Scafati | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 3 | Hepatocellular carcinoma and the risk of occupational exposure显示文摘Hepatocellular carcinoma(HCC)is the most common type of liver cancer.The main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,aflatoxin,hemochromatosis,Wilson’s disease and hemophilia.Occupational exposure to chemicals is another risk factor for HCC.Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent.This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. | Venerando Rapisarda Carla Loreto Michele Malaguarnera Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Maria Irene Ruggeri Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Vito Emanuele Catania Isidoro Di Carlo Adriana Toro Emanuele Bertino Dario Mangano Gaetano Bertino | 2016 | World Journal of Hepatology2016，8，13： | 5 |
| 4 | Umbilical vein blood flow in growth-restricted fetuses显示文摘 | Ferrazzi E Rigano S Bozzo M | | 0，，05： | 1 |
| 5 | Formulating Facial Masks显示文摘 | Rigano L | 2008 | Cosm & Toil2008，129，8： | 1 |
| 6 | Vaccine antigen production in transgenic plants: strategies, gene constructs and perspectives显示文摘 | Sala F Rigano MM Barbante A | 2003 | Vaccine2003，21，78： | 1 |
| 7 | An Update on Immunodiagnosis of Cystic Echinococcosis显示文摘 | Elena Ortona Rachele Rigano Brigitta Buttari | 2003 | Acta Tropica2003，85，： | 1 |
| 8 | Protection against neurodegenerative diseases of iris pseudopumila extracts and their constituents fitoterapia显示文摘 | Conforti F Rigano D Menichini F | | 0，，： | 1 |
| 9 | Modulation of human immune response by Echinococcus granulosus antigen B and itspossible role in evading host defenses显示文摘 | Rigano R Profumo E Brusehi F | 2001 | Infect Immun2001，69，1： | 1 |
| 10 | Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses 显示文摘 | Rigano R Profumo E Bruschi F | 2001 | Infect Immun2001，69，1： | 1 |
| 11 | Targeting of plantderived vaccine antigens to immunoresponsive mucosal sites 显示文摘 | Rigano MM Sala F Arntzen CJ | 2003 | Vaccine2003，21，78： | 1 |
| 12 | Cytokine expression in circulating T lymphocytes from patients undergoing carotid endarterectomy显示文摘 | Rigano R | 2003 | J Cardiovasc Surg (Torino)2003，44，： | 1 |
| 13 | Controlled syn thesis of the DSF cell cell signal is required for biofilm forma tion and virulence in Xanthomonas campestris显示文摘 | Torres P S Malamud F Rigano L A | 2007 | Environ Mi crobiol2007，9，8： | 1 |
| 14 | Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses显示文摘 | Rigano R Profumo E Bruschi F | 2001 | Infect Immun2001，69，： | 1 |
| 15 | In vitro production of cytokines by peripheral blood monouclear cells hom hydatid patients显示文摘 | Rigano R Profmmo E Ioppolo S | 1995 | Clin Exp Immunol1995，99，： | 1 |
| 16 | Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis显示文摘 | Rigano R Buttari B De Falco E | 2004 | Parasit Immunol2004，26，： | 1 |
| 17 | Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses显示文摘 | Rigano R Profumo E Bruschi F | 2002 | Infect Immun2002，69，： | 1 |
| 18 | Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease显示文摘 | Rigano R Profumo E Ioppolo S | 1995 | Clin Exp Immunol1995，102，： | 1 |
| 19 | Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis:results from a phase 2,randomized,parallel-arm,open-label study显示文摘 | Forni GL Perrotta S Giusti A Quarta G Pitrolo L Cappellini MD D'Ascola DG Borgna Pignatti C Rigano P Filosa A Iolascon G Nobili B Baldini M Rosa A Pinto V Palummeri E | | 0，，： | 1 |
| 20 | Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease显示文摘 | Profumo E Ioppolo S | 1995 | Clin Exp Immunol1995，102，2： | 1 |
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