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| 1 | Birth defects in pregestational diabetes:Defect range,glycemic threshold and pathogenesis显示文摘Currently,60 million women of reproductive age(18-44 years old) worldwide,and approximately 3 million American women have diabetes mellitus,and it has been estimated that this number will double by 2030.Pregestational diabetes mellitus(PGD) is a significant public health problem that increases the risk for structural birth defects affecting both maternal and neonatal pregnancy outcome.The most common types of human structural birth defects associated with PGD are congenital heart defects and central nervous system defects.However,diabetes can induce birth defects in any other fetal organ.In general,the rate of birth defects increases linearly with the degree of maternal hyperglycemia,which is the major factor that mediates teratogenicity of PGD.Stringent prenatal care and glycemic control are effective means to reduce birth defects in PGD pregnancies,but cannot reduce the incidence of birth defects to the rate of that is seen in the nondiabetic population.Studies in animal models have revealed that PGD induces oxidative stress,which activates cellular stress signalling leading to dysregulation of gene expression and excess apoptosis in the target organs,including the neural tube and embryonic heart.Activation of the apoptosis signalregulating kinase 1(ASK1)-forkhead transcription factor 3a(Fox O3a)-caspase 8 pathway causes apoptosis in the developing neural tube leading to neural tube defects(NTDs).ASK1 activates the c-Jun-N-Terminal kinase 1/2(JNK1/2),which leads to activation of the unfolded protein response and endoplasmic reticulum(ER) stress.Deletion of the ASK1 gene,the JNK1 gene,or the JNK2 gene,or inhibition of ER stress by 4-Phenylbutyric acid abrogates diabetes-induced apoptosis and reduces the formation of NTDs.Antioxidants,such as thioredoxin,which inhibits the ASK1-Fox O3a-caspase 8 pathway or ER stress inhibitors,may prevent PGD-induced birth defects. | Rinat Gabbay-Benziv E Albert Reece Fang Wang Peixin Yang | 2015 | World Journal of Diabetes2015，6，3： | 10 |
| 2 | Ki67 in breast cancer: prognostic and predictive potential显示文摘 | Rinat Yerushalmi Ryan Woods Peter M Ravdin Malcolm M Hayes Karen A Gelmon | 2010 | Lancet Oncology2010，，2： | 4 |
| 3 | Multimodal bioimaging based on gold nanorod and carbon dot nanohybrids as a novel tool for atherosclerosis detection显示文摘与多样的性质装备的先进 biocompatible 和柔韧的平台高度为动脉粥样硬化患者的早察觉在生物医学的成像应用程序被要求脉管的疾病和癌症。设计 nanohybrids 高贵金属镇静、荧光灯材料是执行多模式的成像克服单个形式的对应物的限制的一个新方法。此处,我们建议一个多模式的对比代理人的新奇设计;也就是,包括金 nanorods (GNR ) 的提高的 nanohybrid 和碳点(CD ) 与硅石(SiO 2) 作为一座桥。nanohybrid (GNR@SiO 2@CD) 建设基于在 SiO 2 和 silane-functionalized CD 之间结合的共有原子价,它与 CD 连接 GNR 形成典型核心壳单位。新奇结构不仅保留并且甚至高度改进 GNR 和 CD 的光性质,而且与赤裸的 GNR 或荧光染料和 CD 相比在散开思考(医生) 和荧光一生成像显微镜学(FLIM ) 大小拥有优异成像性能。GNR@SiO 2@CD nanohybrids 的优异 bioimaging 性质成功地被利用为,铺平向 vitro 医生和在像织物的幽灵以内的巨噬细胞的 FLIM 大小对比的 theranostic 的道路在为动脉粥样硬化和癌症的代理人。 | Xiaojing Liu Luting Liu Xiujie Hu Shuyun Zhou Rinat Ankri Dror Fixler Zheng Xie | 2018 | Nano Research2018，11，3： | 3 |
| 4 | Molecular aspects of anthocyanin fruit tomato in relation to high pigment- 1 显示文摘 | Maya S Michal O S Rinat O | 2008 | Journal of Heredity2008，99，3： | 1 |
| 5 | Adipose-derived stem cells improve grafted burn wound healing by promoting wound bed blood flow显示文摘Background:Researchers have explored the use of adipose-derived stem cells(ASCs)as a cellbased therapy to cover wounds in burn patients;however,underlying mechanistic aspects are not completely understood.We hypothesized that ASCs would improve post-burn wound healing after eschar excision and grafting by increasing wound blood flow via induction of angiogenesis-related pathways.Methods:To test the hypothesis,we used an ovine burn model.A 5 cm^(2) full thickness burn wound was induced on each side of the dorsum.After 24 hours,the burned skin was excised and a 2 cm^(2) patch of autologous donor skin was grafted.The wound sites were randomly allocated to either topical application of 7 million allogeneic ASCs or placebo treatment(phosphate-buffered saline[PBS]).Effects of ASCs culture media was also compared to those of PBS.Wound healing was assessed at one and two weeks following the application of ASCs.Allogeneic ASCs were isolated,cultured and characterized from non-injured healthy sheep.The identity of the ASCs was confirmed by flow cytometry analysis,differentiation into multiple lineages and gene expression via real-time polymerase chain reaction.Wound blood flow,epithelialization,graft size and take and the expression of vascular endothelial growth factor(VEGF)were determined via enzyme-linked immunosorbent assay and Western blot.Results:Treatment with ASCs accelerated the patch graft growth compared to the control(p<0.05).Topical application of ASCs significantly increased wound blood flow(p<0.05).Expression of VEGF was significantly higher in the wounds treated with ASCs compared to control(p<0.05).Conclusions:ASCs accelerated grafted skin growth possibly by increasing the blood flow via angiogenesis induced by a VEGF-dependent pathway. | Osamu Fujiwara Anesh Prasai Dannelys Perez-Bello Amina El Ayadi Irene Y.Petrov Rinat O.Esenaliev Yuriy Petrov David N.Herndon Celeste C.Finnerty Donald S.Prough Perenlei Enkhbaatar | 2020 | Burns & Trauma2020，8，1： | 1 |
| 6 | Mutations in NPHS2 encoding podocin are a prevalent cause of steroid- resistant nephrotic syndrome among Israeli-Arab children 显示文摘 | Frishberg Y Rinat C Megged O | 2002 | J Am Soc Nephrol2002，13，2： | 1 |
| 7 | Plasma Level of N Terminal Pro-Brain Natriuretic Peptide as a Prognostic Marker in Critically Ill Patients显示文摘 | Yaniv Almog Victor Novack Rinat Megralishvili Sergio Kobal Leonid Barski Daniel King Doron Zahger | 2006 | Anesthesia & Analgesia2006，，6： | 1 |
| 8 | Noninvasive monitoring of glucose concentration with optical coherence tomography显示文摘 | Rinat O Esenaliev Krill V Larin lrina V Larina | 2001 | Optics Letters2001，26，13： | 1 |
| 9 | Iron- deficiency anemia (IDA) in infancy and mother-infant interaction during feeding显示文摘 | RINAT A S MELISSA K E SANDRA W J | 2010 | Dev Behav Pediatr2010，31，4： | 1 |
| 10 | Mutated podocin manifesting as CMV - associated congenital nephrotic syndrome 显示文摘 | Frishberg Y Rinat C Feinstein S | 2003 | Pediatr Nephrol2003，18，3： | 1 |
| 11 | B-type natriuretic pep- tides are reliable markers of cardiac strain in CKD pediatric pa- tients显示文摘 | Rinat C Becker-Cohen R Nir A | 2012 | Pediatr Nephrol2012，27，4： | 1 |
| 12 | Mutations in the mitochondrial seryl- tRNAsynthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome显示文摘 | Belostotsky R Ben-Shalom E Rinat C | 2011 | Am J Hum Genet2011，88，2： | 1 |
| 13 | Worst-case distribu- tions for performance evaluation of proportionally guided missiles显示文摘 | RINAT K BEN-ASHER J Z | 2000 | Journal of Guidance Control and Dynamics2000，23，5： | 1 |
| 14 | Familial inheritance of crossed fused renal ectopia显示文摘 | Rinat C Farkas A Frishberg Y | 2001 | Pediatr Nephrol2001，16，3： | 1 |
| 15 | Metastatic Behavior of Breast Cancer Subtypes显示文摘 | HAGEN KENNECKE RINAT YERUSHALMI RYAN WOODS | 2010 | J Clin Oncol2010，28，20： | 1 |
| 16 | Active anthocyanin degradation in Brunfelsia calycina (yesterday- today-tomorrow) flowers 显示文摘 | Hila Vaknin Ayelet Bar- Akiva Rinat Ovadia Ada Nissim Levi Izhak Forer David Weiss Michal Oren- Shamir | 2005 | Planta2005，，2005： | 1 |
| 17 | Combined weekly carbo-platin and paclitaxel as primary treatment of advanced epithelial ovarian carcinoma显示文摘 | Tamar S Joseph M Rinat M | 2009 | Gynecologic Oncology2009，114，2： | 1 |
| 18 | Mutations in NPHS2 encoding podocin are a prevalent cause of steroid-resistant nephrotic syndrome among Israeli-Arab children显示文摘 | Frishberg Y Rinat C Megged O | 2002 | J Am Soc Nephrol2002，13，2： | 1 |
| 19 | Novel applications of feather tip extracts from MDV-infected chickens; diagnosis of commercial broilers, whole genome separation by PFGE and synchronic mucosal infection显示文摘 | Irit Davidson Rinat Borenshtain | 2003 | FEMS Immunology and Medical Microbiology2003，，3： | 1 |
| 20 | Changes in anthocyanin concentration and composition in 'Jaguar' rose flowers due to transient high-tempreture conditions显示文摘 | Gal Dela Etti Rinat Ovadia | 2003 | Plant Science2003，，164： | 1 |
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