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| 1 | 基因重组人巨细胞病毒PPUL32蛋白在诊断中的应用显示文摘为组建可在诊断中应用的高纯度、高效价基因工程抗原,我们在同一克隆中同时表达了人巨细胞病毒(Human cytomegalovirus HCMV)PPUL32蛋白的两个抗原决定簇基因,在诊断中取得满意的结果。 材料和方法 1.克隆 A:表达HCMV PPUL32蛋白位于UL32区第1783~1842核苷酸的抗原决定簇基因。 2.克隆 B:表达HCMV PPUL32蛋白位于UL32区第3070~3144核苷酸的抗原决定族基因;克隆C和D分别表达此基因的二个和三个拷贝。 | 阮强 Ripalti A Landini MP | 1995 | 中华微生物学和免疫学杂志1995，15，2： | 4 |
| 2 | How virus persistence can initiate the tumorigenesis process显示文摘Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective in cells that have already accumulated a number of genetic mutations leading to cell cycle deregulation. Current models for viral driven oncogenesis cannot explain why tumor development in carriers of tumorigenic viruses is a very rare event, occurring decades after virus infection. Considering that viruses are mutagenic agents per se and human oncogenic viruses additionally establish latent and persistent infections, we attempt here to provide a general mechanism of tumor initiation both for RNA and DNA viruses, suggesting viruses could be both necessary and sufficient in triggering human tumorigenesis initiation. Upon reviewing emerging evidence on the ability of viruses to induce DNA damage while subverting the DNA damage response and inducing epigenetic disturbance in the infected cell, we hypothesize a general, albeit inefficient hit and rest mechanism by which viruses may produce a limited reservoir of cells harboring permanent damage that would be initiated when the vi-rus first hits the cell, before latency is established. Cells surviving virus generated damage would consequently become more sensitive to further damage mediated by the otherwise insufficient transforming activity of virus products expressed in latency, or upon episodic reactivations(viral persistence). Cells with a combination of genetic and epigenetic damage leading to a cancerous phenotype would emerge very rarely, as the probability of such an occurrence would be dependent on severity and frequency of consecutive hit and rest cycles due to viral reinfections and reactivations. | Simone Avanzi Gualtiero Alvisi Alessandro Ripalti | 2013 | World Journal of Virology2013，2，2： | 3 |
| 3 | Development of a new cytomegalovirus(CMV) immunoglobulin M(IgM) immunoblot for detection of CMV-specific IgM显示文摘 | Lazzarotto T Ripalti A Bergamini G | | 0，，： | 1 |
| 4 | Developmentof a new cytomegalovirus (CMV) immunoglobulin M (IgM) immunoblot for detection of CMV specific IgM 显示文摘 | Lazzarotto T Ripalti A Bergamini G | 1998 | J Clin Microbiol1998，36，11： | 1 |
| 5 | Development of a new cytomegalovirus (CMV) Immunoblot for detection of CMV-specific IgM显示文摘 | LAZZAROTTO T RIPALTI A BERGAMINI G | 1998 | J Clin Microbiol1998，36，11： | 1 |
| 6 | Human cytomegalovirus structur-al proteins:immune reaction against ppl50 synthetic peptides显示文摘 | Landini MP Ripalti A Sra K | 1991 | JClin Microbiol1991，29，9： | 1 |
| 7 | Identification and prelimi-nary use of recombinant lambda gtll fusion proteins in human cyto-megalovirus diagnosis 显示文摘 | Ripalti A Landini M P Mocarski ES | 1989 | J Gen Virol1989，70，5： | 1 |
| 8 | Prokaryotic expression ofa large fragment of the most antigenic cytomegalovirus DNA-bindingprotein(ppUL44)and its reactivity with human antibodies显示文摘 | Ripalti A Dal Monte P Boccuni M C | 1994 | J VirolMethods1994，46，1： | 1 |
| 9 | Liver/kidrey microsmal anti body type 1 targets CYP2D6 on hepatocyte plasma membrane显示文摘 | Muratori L Parola M Ripalti A | 2000 | Gut2000，46，： | 1 |
| 10 | Stabley expressed antisense RNA to cytomegalovirus UL 83 inhibits viral replication显示文摘 | Bessia C Ripalti A | 1996 | J Virol1996，70，4： | 1 |
| 11 | Construction of polyepitope fusion antigens of human cytomegalovirus ppUL32: reactivity with human antibodies显示文摘 | Ruan Q Boccuni MC | 1994 | J Clin Microbiol1994，32，： | 1 |
| 12 | Human cytomegalovirus structural proteins: immune reaction against pp150 synthetic pep- tides显示文摘 | Landini MP Ripalti A Sra K | 1991 | J Clin Microbiol1991，29，9： | 1 |
| 13 | Identification and preliminary use of recombinant lambda gt11 fusion proteins in hu- man cytomegalovirus diagnosis显示文摘 | Ripalti A Landini MP Moearski ES | 1989 | J Gen Virol1989，70，5： | 1 |
| 14 | Prokaryotic expres- sion of a large fragment of the most antigenic cytomegalovirus DNA binding protein (ppUL44) and its reactivity with human an- tibodies显示文摘 | Ripalti A Dal Monte P Boecuni MC | 1994 | J Virol Methods1994，46，1： | 1 |
| 15 | Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane 显示文摘 | Muratori L Parola M Ripalti A | 2000 | Gut2000，46，4： | 1 |
| 16 | Human cytomegalovirus late-phase maturation is blocked by stably expressed UL32 antisense mRNA in astrocytoma cells显示文摘 | Meyer HH Ripalti A Landini MP | 1997 | J Gen Virol1997，78，10： | 1 |
| 17 | Stabley expressed antisense RNA to cytomegalovirus UL 83 inhibits viral replication 显示文摘 | Dal MP Bessia C Ripalti A | 1996 | J Virol1996，70，4： | 1 |
| 18 | Prokaryotic expression of a large fragment of the most antigenic cytomegalovirus DNA-bindingprotein (ppUL44) and its reactivity with human antibodies显示文摘 | Ripalti A Dal Monte P Boccuni MC | 1994 | J Virol Methods1994，46，1： | 1 |
| 19 | et al,Human Cytomegalovirus DNA Polymerase Catalytic Subunit pUL54 Possesses Independently Acting Nuclear Localization and ppUL44 Binding Motifs显示文摘 | Alvisi G Ripalti A Giannandrea M | 2006 | Traffic2006，7，10： | 1 |
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