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| 1 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 2 | Female sex hormone, progesterone, ameliorates the severity of SARS-CoV-2-caused pneumonia in the Syrian hamster model显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 260 million people worldwide and causes coronavirus disease 2019(COVID-19)with clinical spectrum ranging from mild to severe pneumonia.Recent clinical trials and experimental animal studies demonstrated that the severity of COVID-19 is lower in the females than in males. | Lunzhi Yuan Huachen Zhu Kun Wu Ming Zhou Jian Ma Rirong Chen Qiyi Tang Tong Cheng Yi Guan Ningshao Xia | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 3 | Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination显示文摘 | Zhenghua Ren Jianhua Cui Zeren Huo Jinru Xue Hao Cui Bin Luo Lanjin Jiang Rirong Yang | 2012 | International Immunopharmacology2012，，4： | 2 |
| 4 | Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 200 million people,causing coronavirus disease 2019(COVID-19)worldwide.Lungs are the primary target organ of SARS-CoV-2 infection.The mild COVID-19 cases develop symptoms of fever,fatigue,muscle weakness,chest pain,headache and cough(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020),while severe COIVD-19 cases might have pneumonia,breathing difficulties,multiple organ failure and death(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020).Both the clinicians and researchers have largely focused on the acute phase of COVID-19,but the long-term health consequences of the COVID-19 patients after clinical recovery remain less investigated.Several clinical cohorts demonstrated that some patients discharged from hospital still experience symptoms including fatigue,muscle weakness,chest pain,cough and breathing difficulties(Carfi et al.,2020;Lim et al.,2020;Huang et al.,2021).Moreover,severely impaired pulmonary diffusion capacities and abnormal chest imaging manifestations were observed in some convalescent patients(Huang et al.,2021).Surprisingly,residual virus(An et al.,2020;Yao et al.,2020;Kim et al.,2021)were detected in some convalescent patients. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Liuqin Yu Wenjia Chen Wenshan Hong Jia Wang Yao Chen Kun Wu Wangheng Hou Yali Zhang Shengxiang Ge Yixin Chen Quan Yuan Qiyi Tang Tong Cheng Yi Guan Ningshao Xia | 2022 | Protein & Cell2022，13，1： | 1 |
| 5 | Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation显示文摘Dear Editor,TAR DNA-binding protein 43 kDa(TDP-43)undergoes liquid-liquid phase separation(LLPS)and forms reversible,cytoprotective nuclear bodies(NBs)under stress.1 Abnormal liquid-to-solid phase transition condenses TDP-43 into irreversible pathological fibril,which is associated with neurodegenerative disorders including amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD). | Jinge Gu Chen Wang Rirong Hu Yichen Li Shengnan Zhang Yunpeng Sun Qiangqiang Wanq Dan Li Yanshan Fang Cong Liu | 2021 | Cell Research2021，31，9： | 1 |
| 6 | An argumentum about variational method and the electromagnetism field in unifor-mity column waveguide显示文摘 | Zhang Rirong Di Yingjie Li Jutang | 1999 | Radio Communications Technology1999，25，3： | 1 |
| 7 | Trajectory of fecal lactoferrin for predicting prognosis in ulcerative colitis显示文摘Objectives:To investigate the characteristics and prognostic value of fecal lactoferrin trajectories in ulcerative colitis(UC).Methods:This study used data from the UNIFI trial(ClinicalTrials.gov,NCT02407236)and included patients who received ustekinumab during induction for trajectory modeling(n=637).Patients who received ustekinumab during maintenance therapy were used for 1-year outcome analyses(n=403).The levels of fecal lactoferrin,fecal calprotectin,and serum C-reactive protein were measured at weeks O,2,4,and 8.The trajectories of these biomarkers were developed using a latent class growth mixed model.Results:The trajectories of fecal lactoferrin,fecal calprotectin,and serum C-reactive protein were distinct,but all were associated with prior exposure to anti-tumor necrosis factor agents and vedolizumab.Furthermore,the fecal lactoferrin trajectory was the most valuable predictor of endoscopic,clinical,and histological remission.Compared to the high/moderate-rapid decrease trajectory group,the moderate-slow decrease,high-slow decrease,and high-stable groups had adjusted odds ratios(95%confidence interval)of o.38(0.18,0.78;P=0.010),0.47(0.23,0.93;P=0.032),and 0.33(0.17,0.63;P=0.001),respectively,of 1-year endoscopic remission.Patients with high/moderate-rapid decrease trajectories also had the highest likelihood of achieving clinical and histological remission.Finally,we developed a patient-stratification scheme based on fecal lactoferrin trajectories and concentrations.Patients with good,moderate,and poor prognoses in the scheme had a distinct probability of achieving 1-year endoscopic remission(52.7%,30.9%,and 12.8%,respectively).Conclusions:The trajectory of fecal lactoferrin is a valuable prognostic factor for 1-year remission in UC. | Rirong Chen Li Li Yizhe Tie Minhu Chen Shenghong Zhang | 2023 | Precision Clinical Medicine2023，6，3： | 0 |
| 8 | Infection,pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile,adult and aged Syrian hamsters显示文摘The new predominant circulating SARS-CoV-2 variant,Omicron,can robustly escape current vaccines and neutralizing antibodies.Although Omicron has been reported to have milder replication and disease manifestations than some earlier variants,its pathogenicity in different age groups has not been well elucidated.Here,we report that the SARS-CoV-2 Omicron BA.1 sublineage causes elevated infection and lung pathogenesis in juvenile and aged hamsters,with more body weight loss,respiratory tract viral burden,and lung injury in these hamsters than in adult hamsters.Juvenile hamsters show a reduced interferon response against Omicron BA.1 infection,whereas aged hamsters show excessive proinflammatory cytokine expression,delayed viral clearance,and aggravated lung injury.Early inhaled IFN-α2b treatment suppresses Omicron BA.1 infection and lung pathogenesis in juvenile and adult hamsters.Overall,the data suggest that the diverse patterns of the innate immune response affect the disease outcomes of Omicron BA.1 infection in different age groups. | Lunzhi Yuan Huachen Zhu Peiwen Chen Ming Zhou Jian Ma Xuan Liu Kun Wu Rirong Chen Qiwei Liu Huan Yu Lifeng Li Jia Wang Yali Zhang Shengxiang Ge Quan Yuan Qiyi Tang Tong Cheng Yi Guan Ningshao Xia | 2022 | Cellular & Molecular Immunology2022，19，12： | 0 |
| 9 | Interfacial precipitation in{1012}twin boundaries of a Mg-Gd-Zn-Zr alloy显示文摘Twinning and precipitation play important roles in deformation and strengthening of magnesium alloys.In this work,interfacial precipitation in{1012}twin boundaries(TBs)of a cold-stamped Mg-12Gd-1.2Zn-0.4Zr alloy was investigated using atomic-resolution high-angle annular dark-field scanning transmission electron microscopy.Extended periodic segregation of Gd+Zn atoms in the~86.2°{1012}TBs with basal-prismatic facets and in the symmetric tilting TBs(obviously>86.2°)frequently occurred,resulted in the formation of new interfacial phases,namelyβ_(TB)’having a monoclinic structure in the TBs with two segregation layers andβ_(TB) having a tetragonal structure in the TBs with three or more segregation layers.The formation ofβ_(TB) clearly accelerates peak-aging and improves the alloy’s strength. | Zixiang Yan Qiang Yang Fanzhi Meng Rui Ma Rirong Bao Xiaojuan Liu Jian Meng Xin Qiu | 2021 | Journal of Materials Science & Technology2021，，34： | 0 |
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