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| 1 | 基于人工智能干预措施的临床试验方案指南:SPIRIT-AI扩展显示文摘《干预试验方案报告标准》(Standard Protocol Items:Recommendations for Interventional Trials,SPIRIT)2013通过为试验最小条目集的确定提供基于证据的建议,旨在改善临床试验方案报告的完整性。该指南有助于促进新干预措施的透明评估。近年来,人们越来越认识到,涉及人工智能(artificial interlligence,AI)的干预措施需要经过严格的前瞻性临床研究评估,以证明其对健康结局的影响。《人工智能干预试验方案报告标准(Standard Protocol Items:Recommendations for Interventional Trials-Artificial Intelligence,SPIRIT-AI)扩展》是一份新的评估AI干预措施的临床试验方案的报告指南。它与配套的《人工智能试验报告统一标准》(Consolidated Standards of Reporting Trials-Artificial Intelligence,CONSORT-AI)是同步编制的。这两项指南的编制通过分阶段的文献回顾和专家咨询等过程达成共识,产生26项候选条目。由国际多方利益相关小组在两阶段德尔菲调查(103个利益相关者)中对这些条目进行了咨询,并在共识会议上达成一致意见(31个利益相关者),通过34个试点参与进行了改进和优化。SPI RI T-AI扩展包括15项对AI干预的临床试验方案非常重要的新条目。除SPIRIT 2013的核心条目外,这些新条目也应定期报告。SPIRIT-AI建议研究人员提供关于AI干预的清晰描述,包括使用AI所需的说明和操作技能、AI干预集成环境的设置、输入和输出数据处理的注意事项、人-AI交互和错误案例分析。SPI RI T-AI将有助于提高AI干预临床试验方案的透明度和完整性,也有助于编辑、同行评审以及普通读者理解、解释和严格评估临床试验的设计和偏倚风险。 | 熊云云(译) 李子孝(译) 丁玲玲(译) 谷鸿秋(译) 王春娟(译) 王春雪(译) 赵性泉(译) 王拥军(译) CRUZ RIVERA S LIU X CHAN A | 2020 | 中国卒中杂志2020，15，11： | 20 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 4 | Non-alcoholic fatty liver disease in patients with intestinal, pulmonary or skin diseases: Inflammatory cross-talk that needs a multidisciplinary approach显示文摘Non-alcoholic fatty liver disease(NAFLD)is currently considered the most common cause of liver disease.Its prevalence is increasing in parallel with the obesity and type 2 diabetes mellitus(DM2)epidemics in developed countries.Several recent studies have suggested that NAFLD may be the hepatic manifestation of a systemic inflammatory metabolic disease that also affects other organs,such as intestine,lungs,skin and vascular endothelium.It appears that local and systemic proinflammatory/anti-inflammatory cytokine imbalance,together with insulin resistance and changes in the intestinal microbiota,are pathogenic mechanisms shared by NAFLD and other comorbidities.NAFLD is more common in patients with extrahepatic diseases such as inflammatory bowel disease(IBD),obstructive syndrome apnea(OSA)and psoriasis than in the general population.Furthermore,there is evidence that this association has a negative impact on the severity of liver lesions.Specific risk characteristics for NAFLD have been identified in populations with IBD(i.e.age,obesity,DM2,previous bowel surgery,IBD evolution time,methotrexate treatment),OSA(i.e.obesity,DM2,OSA severity,increased transaminases)and psoriasis(i.e.age,metabolic factors,severe psoriasis,arthropathy,elevated transaminases,methotrexate treatment).These specific phenotypes might be used by gastroenterologists,pneumologists and dermatologists to create screening algorithms for NAFLD.Such algorithms should include non-invasive markers of fibrosis used in NAFLD to select subjects for referral to the hepatologist.Prospective,controlled studies in NAFLD patients with extrahepatic comorbidities are required to demonstrate a causal relationship and also that appropriate multidisciplinary management improves these patients’prognosis and survival. | Mercedes Perez-Carreras Begoña Casis-Herce Raquel Rivera Inmaculada Fernandez Pilar Martinez-Montiel Victoria Villena | 2021 | World Journal of Gastroenterology2021，27，41： | 2 |
| 5 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 6 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 7 | Apolymorphism in thealpha2a- adrenoceptor gene and enduiance athlete status 显示文摘 | Wlofatth B Rivera M A Oppert J M | 2000 | Mid Sci sports Exerc2000，32，10： | 1 |
| 8 | 2-Week triple therapy for Helicobacter pylori infection is better than 1-week in clinical Practice: a large prospective single-center randomized st udy显示文摘 | Paoluzi P Iacopini F Crispino P Nardi F Bella A Rivera M Rossi P Gurnari M Caracciolo F Zippi M Pica R | 2006 | Helicobacter2006，11，： | 1 |
| 9 | Phenylalanine hydroxylase deficiency:Molecular epidemiology and predictable BH (4)-responsiveness in South Portugal PKU patients显示文摘 | Rivera I Mendes D Afonso A | 2011 | Mol Genet Metab2011，104，1： | 1 |
| 10 | Small increases in extravascular lungwater are accu- rately detected by transpulmonary thermodilution 显示文摘 | Fern Adez - Mond jar E Rivera - Fern Adez R Garc a - Del- gadoM | 2005 | J Trauma2005，59，： | 1 |
| 11 | Immune-mediated mechanisms of parasite tissuesequestration during experimental cerebral malaria显示文摘 | Amante FH Haque A Stanley AC Rivera Fde L Randall LM Wilson YA | 2010 | J Immu-nol2010，185，6： | 1 |
| 12 | Novel infectivity-enhancedoncolytic adenovirus with a capsid-incorporated dual-imagingmoiety for monitoring virotherapy in ovarian cancer显示文摘 | Kimball KJ Rivera A Zinn KR | 2009 | Mol Ima-ging2009，8，： | 1 |
| 13 | Safety and efficacy of first- line bevacizumab with FOLFOX,XELOX,FOLFIRI and fluoropyrim- idines in metastatic colorectal cancer:the BEAT study显示文摘 | Van Cutsem E Rivera F Berry S et a/ | 2009 | Ann Oncol2009，20，11： | 1 |
| 14 | T-bet-dependent S1 P5 expression in NK cells promotes egress from lymph nodes and bone marrow显示文摘 | Jenne C N Enders A Rivera R | 2009 | The Journal of experimental medicine2009，206，11： | 1 |
| 15 | Enterobacterial repetitive intergenic consensus sequences and the PCR to generate fingerprints of genomic DNAs from Vibrio cholerae O1,O139,and non-O1 strains显示文摘 | Rivera I G M A R Chowdhury A Huq | 1995 | Appl Environ Microbiol1995，61，： | 1 |
| 16 | Musa genetic diversityrevealed by SRAP and AFLP显示文摘 | Youssef M James A C Rivera M R | 2011 | Molecular Biotechnology2011，47，3： | 1 |
| 17 | Innate recognition of cell wall beta-Glucans drives invariant natural killer T cell responses against fungi显示文摘 | Cohen NR Tatituri RV Rivera A | 2011 | Cell Host Microbe2011，10，： | 1 |
| 18 | MiR - 107 and miR -99a -3p predict chemotherapy response in patients with advanced colorectal cancer显示文摘 | Molina - Pinelo S Carnero A Rivera F | 2014 | BMC Cancer2014，14，： | 1 |
| 19 | Isolation and characterization of nine microsatellite loci from the Hawaiian grouper Epinephelus quernus(Serranidae)for population genetic analyses显示文摘 | Rivera M A J Graham G C Roderick G K | 2003 | Marine Biotechnology2003，5，2： | 1 |
| 20 | Kupffer cell oxidant production in central to the mechanism of peroxisome proliferators显示文摘 | Rose M L Rivera C A Bradford B U | 1999 | Carcinogenesis1999，20，1： | 1 |
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