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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Accuracy of biometric formulae for intraocular lens power calculation in a teaching hospital显示文摘AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching hospital.METHODS: A retrospective chart review was conducted from November 2013 to May 2018. One eye of each patient who underwent cataract surgery with a monofocal intraocular lens(IOL) was included. The range of postoperative follow-up period was from 3 wk to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae were used to predict the postoperative refraction for all cataract surgeries. For each formula, we calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes within ±0.25 diopter(D) and ±0.5 D of predicted refraction. We performed subgroup analyses for short(AL<22.0 mm), medium(AL 22.0-25.0 mm), and long eyes(AL>25.0 mm).RESULTS: A total of 1131 patients were screened, and 909 met the inclusion criteria. Resident ophthalmologists were the primary surgeons in 710(78.1%) cases. We found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the lowest MAE(0.384 D) and the highest percentage of eyes with postoperative refraction within ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and lowest percentage within ±0.5 D of predicted refraction(<55%) in short eyes.CONCLUSION: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error. | Kevin S Tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 3 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 4 | Apolymorphism in thealpha2a- adrenoceptor gene and enduiance athlete status 显示文摘 | Wlofatth B Rivera M A Oppert J M | 2000 | Mid Sci sports Exerc2000，32，10： | 1 |
| 5 | Identification of cellular proteins modified in response to African swine fever virus infection by proteomics显示文摘 | Alfonso P Rivera J Hernáez B | 2004 | Proteomics2004，4，7： | 1 |
| 6 | Deposition and characterization of cerium oxide conversion coatings on aluminum alloy 7075-T6 显示文摘 | RIVERA B F OHNSONB Y J O'KEEFE M J | 2004 | Surface and Coatings Technology2004，176，3： | 1 |
| 7 | Platinum based chemotherapy plus cetuximab in head and neck cancer 显示文摘 | Vermorken J B Mesia R Rivera F | 2008 | N Engl J Med2008，359，11： | 1 |
| 8 | Kupffer cell oxidant production in central to the mechanism of peroxisome proliferators显示文摘 | Rose M L Rivera C A Bradford B U | 1999 | Carcinogenesis1999，20，1： | 1 |
| 9 | Effect of different sources and levels of selenium on performance, meat quality, and tissue characteristics of broilers显示文摘 | Oliveira T F B Rivera F R Mesquita F R | 2014 | The Journal of Applied Poultry Research2014，23，1： | 1 |
| 10 | Three mitochondrial DNA restriction polymorphisms in elite endurance athletes and sedentary controls显示文摘 | Rivera MA Wolfarth B Dionne FT | 1998 | Med Sci Sports Exerc1998，30，5： | 1 |
| 11 | Identification of cellular proteins modified in response to African swine fever virus infection by proteomics显示文摘 | ALFONSO P RIVERA J HERNAEZ B | 2004 | Proteomics2004，4，20： | 1 |
| 12 | Differential contribution of endothelial function to vascular reactivity in conduit and resistance arteries from deoxycorticosterone- salt hypertensive rats 显示文摘 | WHITE R M RIVERA C O DAVISON C B | 1996 | Hypertension1996，27，6： | 1 |
| 13 | Dynamics of dyads in social networks: assortative, relational, and proximity mechanisms显示文摘 | Rivera M T Soderstrom S B Uzzi B | 2010 | Annu Roy Sociol2010，36，1： | 1 |
| 14 | Three Mitochondrial DNA Restriction Polymorphisms in Elite Endurance Athletes and Sedentary Controls显示文摘 | RIVERA M A WOLFARTH B DIONNE F T | 1998 | Med Sci Sports Exe1998，30，5： | 1 |
| 15 | Observation of ferrotoroidic domains 显示文摘 | Van Aken B B Rivera J R Schmid H | 2007 | Nature2007，449，： | 1 |
| 16 | Improved anti-tumor therapy based upon infectivity- enhanced adenoviral delivery of RNA interference in ovarian carcinoma cell lines 显示文摘 | Numnum TM Makhija S Lu B Wang M Rivera A Stoff-Khalili M | 2008 | Gynecol Oncol2008，108，1： | 1 |
| 17 | Muscle-specific creatine kinase gene polymorphisms in elite endurance athletes and sedentary controls显示文摘 | Rivera MA Dionne FT Wolfarth B | 1997 | Med Sci Sports Exerc1997，29，11： | 1 |
| 18 | Phase Ⅱ study of pegylated liposomal doxorubicin in combination with gemcitabine in patients with metastastic breast cancer显示文摘 | Rivera E Valero V Arum B | 2003 | J Clin Oncol2003，21，17： | 1 |
| 19 | Electric vehicle charging station using a neutral point clamped converter with bipolar DC bus显示文摘 | Rivera S Wu B Kouro S | 2015 | IEEE Transactions on Industrial Electronics2015，62，4： | 1 |
| 20 | A Polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status显示文摘 | Wolfarth B Rivera MA Opper JM | 2000 | 1ed Sc i SportsExerc2000，32，10： | 1 |
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