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| 1 | 阿尔茨海默病患者脑组织中突触蛋白表达改变显示文摘阿尔茨海默病(Alzheimer’s disease,AD)是一种常见于老年人的中枢神经系统退行性变疾病,以进行性认知功能障碍为主要临床表现,其典型神经病理学特征是老年斑、神经原纤维缠结及神经元丢失等。近来研究显示,AD脑中突触功能并非最佳状态,许多与突触功能密切相关的蛋白表达异常。 | 曹颖 Rivka Ravid 官志忠 | 2009 | 中华病理学杂志2009，38，12： | 6 |
| 2 | Etiology and long-term outcome of extrahepatic portal vein obstruction in children显示文摘AIM:To study the management and outcome of children with extrahepatic portal vein obstruction(EHPVO) in a whole country population.METHODS:A nationwide multicenter retrospective case series of children with EHPVO was conducted.Data on demographics,radiographic studies,laboratory workup,endoscopic and surgical procedures,growth and development,were extracted from the patients' charts.Characteristics of clinical presentation,etiology of EHPVO,management and outcome were analyzed.RESULTS:Thirty patients,13 males and 17 females,19(63.3%) Israeli and 11(36.7%) Palestinians,were included in the analysis.Age at presentation was 4.8± 4.6 years,and mean follow-up was 4.9±4.3 years.Associated anomalies were found in 4 patients.The incidence of EHPVO in Israeli children aged 0-14 years was 0.72/million.Risk factors for EHPVO were detected in 13(43.3%)patients,including 9 patients(30%) with perinatal risk factors,and 4 patients(13.3%) with prothrombotic states:two had low levels of protein S and C,one had lupus anticoagulant,and one was homozygous for methyltetrahydrofolate reductase mutations.In 56.6% of patients,no predisposing factors were found.The most common presenting symptoms were an incidental finding of splenomegaly(43.3%),and upper gastrointestinal bleeding(40%).No differences were found between Israeli and Palestinian children with regard to age at presentation,etiology and clinical symptoms.Bleeding occurred in 18 patients(60%),at a median age of 3 years.Sclerotherapy or esophageal banding was performed in 20 patients.No sclerotherapy complications were reported.Portosystemic shunts were performed in 11 patients(36.6%),at a median age of 11(range 3-17)years:splenorenal in 9,mesocaval in 1,and a meso-Rex shunt in 1 patient.One patient underwent splenectomy due to severe pancytopenia.Patients were followed up for a median of 3(range 0.5-15)years.One patient died aged 3 years due to mucopolysaccharidase deficiency type Ⅲ.None of the patients died due to gastrointestinal bleeding.CONCLUSION:EHPVO is a rare disorder.The etiological factors are still mostly unknown,and the endoscopic and surgical treatment options ensure a good long-term prognosis. | Batia Weiss Eyal Shteyer Asaf Vivante Drora Berkowitz Shimon Reif Zvi Weizman Yoram Bujanover Rivka Shapiro | 2010 | World Journal of Gastroenterology2010，16，39： | 6 |
| 3 | 核转录因子及炎性趋化因子在阿尔茨海默病患者脑组织中的改变显示文摘目的 探讨核转录因子(NF) -κBp65、炎性趋化因子单核细胞趋化蛋白1(MCP-1/CCL-2)、巨噬细胞炎性蛋白-1α(MIP-1 α/CCL-3)和胶质纤维酸性蛋白(GFAP)等在阿尔茨海默病(AD)发病中的改变。方法 选择尸体解剖后的10例AD患者及8例对照脑组织,用免疫组织化学EnVision方法检测海马、大脑额叶及颞叶皮质中NF-κBp65、MCP-1、MIP-1α、GFAP和Aβ1-42的表达。结果 与对照组相比,AD患者脑组织海马、额叶和颞叶皮质等部位均显示神经细胞中NF-κBp65[每高倍视野(×400)阳性细胞数分别为3.6±1.5、2.2±1.2和2.2±1.2]表达较对照组(每高倍视野阳性细胞数分别为0.31±0.20、0.25±0.20和0.25±0.20)明显增高(P<0.05);MCP-1及MIP-1α在海马、额叶和颞叶皮质等部位神经细胞中(每高倍视野阳性细胞数分别为8.0±1.3、8.8±1.0、9.3±1.4;及8.1±1.5、12.5±1.1、6.4±1.1)表达均较对照组(每高倍视野阳性细胞数分别为4.5±0.9、4.5±0.6、4.0±1.8;及5.0±1.9、6.3±2.2、3.8±1.5)明显增多(P<0.05);GFAP显示的星形胶质细胞数增多(P<0.05),并大量聚集在老年斑周围。相关系数分析表明,在AD脑组织中MCP-1、MIP-1α蛋白水平与NF-κBp65的改变有关。结论 AD脑组织中核转录因子及炎性趋化因子表达升高,NF-κBp65可能调节MCP-1和MIP-1α的表达,其机制可能与Aβ引起的炎性作用有关。 | 廖媛 官志忠 Rivka Ravid | 2011 | 中华病理学杂志2011，40，9： | 5 |
| 4 | Maternal Lamotrigine Treatment and Elevated Neonatal Gamma-Glutamyl Transpeptidase显示文摘 | Gal Dubnov-Raz Rivka Shapiro Paul Merlob | 2006 | Pediatric Neurology2006，，3： | 1 |
| 5 | New Structuralism: Design, Engineering and Architectural Technologies显示文摘 | Rivka Oxman Robert Oxman | 2010 | Archit Design2010，，4： | 1 |
| 6 | Downregulation of Microglial Activation by Achillolide A显示文摘 | Anat Elmann Alona Telerman Sharon Mordechay Hilla Erlank Miriam Rindner Yoel Kashman Rivka Ofir | 2015 | Planta Med2015，，： | 1 |
| 7 | Decreased protein levels of nicotinic receptor subunits in the hippocampus and tenporal cortex of patients with Alzheimer's disease显示文摘 | Guan Z Z Zhang X Rivka R | 2000 | J Neurochem 20002000，237，： | 1 |
| 8 | Meconium Ileus Caused by Mutations in GUCY2C , Encoding the CFTR-Activating Guanylate Cyclase 2C显示文摘 | Hila Romi Idan Cohen Daniella Landau Suliman Alkrinawi Baruch Yerushalmi Reli Hershkovitz Nitza Newman-Heiman Garry R. Cutting Rivka Ofir Sara Sivan Ohad S. Birk | 2012 | The American Journal of Human Genetics2012，，5： | 1 |
| 9 | The eyestalk androgenic gland testis endocrine axis in the crayfish Cherax quadricarinatus显示文摘 | Isam Khalaila Rivka Manor Simy Weil | 2002 | General and Comparative Endocrinology2002，，127： | 1 |
| 10 | Primary serous papillary carcinoma of the peritoneum: CT findings显示文摘 | Rivka Z Marjorie H Myra S | 2001 | Clinical Radiology2001，56，： | 1 |
| 11 | Effects of Ca^2+-Ionophore A23187 and calmodulin antagonists on regulatory mechanisms of glycolysis and cell viability of NIH-3T3 fibrohlasts显示文摘 | Michal A S Rivka B | 1999 | Mol Gen Metab1999，67，4： | 1 |
| 12 | One-step synthesisof 2-and 4-nitrobenzylcyanides 显示文摘 | Asher K Rivka M | 1987 | Synthesis1987，，5： | 1 |
| 13 | Percutaneoustransluminal angioplasty of an occluded surgical splenorenal shuntin a 4-year-old child after liver transplantation 显示文摘 | Ethan Yussim Rivka Shapiro Eytan Mor | 2005 | PediatricRadiology2005，35，7： | 1 |
| 14 | Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid 13 peptide and inhibit/Aβ-induced toxicity显示文摘 | JoAnne M Rivka G Anna J | 2001 | J Biol Chem2001，275，18： | 1 |
| 15 | Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases显示文摘 | GILAD H RIVKA C | 1993 | Biochim Biophys Acta1993，，1151： | 1 |
| 16 | Programmable and autonomous computing machine made of biomolecules显示文摘 | Benenson Y Pax-Elizur T Rivka A | 2001 | Nature2001，1414，11： | 1 |
| 17 | Extrarenal manifestations of severe acute pyelonephritis: CT findings in 21 cases显示文摘 | Rivka Zissin Alexandra Osadchy Gabriela Gayer Yona Kitay-Cohen | 2006 | Emergency Radiology2006，，： | 1 |
| 18 | Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease显示文摘 | Guan ZZ Zhang X Rivka R | 2000 | Neurochemistry2000，74，1： | 1 |
| 19 | Elec- tive induction of labor in women with gestational diabetes mellitus: an intervention that modifies the risk of cesarean section 显示文摘 | Maayan Bas - lando Naama Srebnik Rivka Farkash | 2014 | Ar- chives of Gynecology and Obstetrics2014，290，5： | 1 |
| 20 | Decreased protein levels of nicotinic receptor subunits in the hippocampus and tenporalcortex of patient s with Alzheimer's disease 显示文摘 | Guan ZZ Zhang X Rivka R | 2000 | J Neurochem2000，74，： | 1 |
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