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| 1 | Ectopic pregnancy early diagnosis markers显示文摘 | Segal S Mercado R Rivnay B | | 0，，1： | 1 |
| 2 | Evidence for different aetiologies of low estradiol response to FSH:age-related accelerated luteinization of follicles or presence of ovarian autoantibodies显示文摘 | Luborsky JL Thiruppathi P Rivnay B | 2002 | Human Reproduction2002，17，10： | 1 |
| 3 | Evidence for different aetiologies of lowest radio response to FSH:age-related accel erated luteinization of follicles or presence of ovarian auto antibodies显示文摘 | Luborsky JL Thiruppathi P Rivnay B | 2002 | Hum Reprod2002，17，10： | 1 |
| 4 | Conducting Polymer Electrodes for Electroencephalography显示文摘 | Leleux P Badier J M Rivnay J | | 0，，： | 1 |
| 5 | High Transconductance Organic Electrochemical Transistors显示文摘 | Khodagholy D Rivnay J Sessolo M | | 0，，： | 1 |
| 6 | Ectopic pregnancy early diagno- sis markers显示文摘 | Segal S Mercado R Rivnay B | 2010 | Minerva Ginecol2010，62，1： | 1 |
| 7 | Combined analysis of phospholipids by high -performance liquid chromatography and thinlayer chromatography 显示文摘 | Rivnay B | 1984 | Journal of Chromatography1984，294，： | 1 |
| 8 | Evidence for different aetiologies of low estradiol response to FSH:age-related luteinization of follicles or presence of ovarian autoantibodies 显示文摘 | Luborsky J L Thiruppathi P Rivnay B et aI | 2002 | Hum Reprod2002，10，7： | 1 |
| 9 | Unexpected interaction between PEDOT and phosphonium ionic liquids显示文摘 | Armel V Rivnay J Malliaras G | | 0，，30： | 1 |
| 10 | Ectopic pregnancy early diagnosis markers显示文摘 | Segal S Mercado R Rivnay B | 2010 | Minerva Ginecol2010，62，： | 1 |
| 11 | Ectopic pregnancy early diagnosis markers 显示文摘 | Segal S Mercado R Rivnay B | 2010 | Minerva Ginecol2010，62，1： | 1 |
| 12 | Combined analysis of phospholipids by high-performance liquid chromatography and thin-layer chromatography analysis of phospholipid classes in commercial soyabean lecithin显示文摘 | Rivnay B | 1984 | J Chromatogr1984，294，： | 1 |
| 13 | Ectopic pregnancy early diagnosis markers显示文摘 | Segal S Mercado R Rivnay B | 2010 | Minerva Ginecol2010，62，1： | 1 |
| 14 | Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity显示文摘Amphotericin B(AmB)is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections.Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer,which heat treatment(curing)modifies.Although toxicity was found related to aggregation status-loose aggregates significantly more toxic than tight aggregates-the precise mechanism linking aggregation and toxicitywas notwell understood.This study directlymeasured drug release rate fromvarious AmB liposomal preparations made with modified curing protocols to evaluate correlations among drug aggregation state,drug release,and in vitro toxicity.UV–Vis spectroscopy of these products detected unique curing-induced changes in the UV spectral features:a∼25nm blue-shift of the main absorption peak(λ_(max))in aqueous buffer and a decrease in the OD_(346)/OD_(322) ratio upon thermal curing,reflecting tighter aggregation.In vitro release testing(IVRT)data showed,by applying and fitting first-order release kinetic models for one or two pools,that curing impacts two significant changes:a 3–5-fold drop in the overall drug release rate and a ten-fold decrease in the ratio between the loosely aggregated and the tightly aggregated,more thermodynamically stable drug pool.The kinetic data thus corroborated the trend independently deduced from the UV–Vis spectral data.The in vitro toxicity assay indicated a decreased toxicity with curing,as shown by the significantly increased concentration,causing half-maximal potassium release(TC50).The data suggest that the release of AmB requires dissociation of the tight complexes within the bilayer and that the reduced toxicity relates to this slower rate of dissociation.This study demonstrates the relationship between AmB aggregation status within the lipid bilayer and drug release(directly measured rate constants),providing a mechanistic link between aggregation status and in vitro toxicity in the liposomal formulations. | Yuri Svirkin Jaeweon Lee Richard Marx Seongkyu Yoon Nelson Landrau Md Abul Kaisar Bin Qin Jin H.Park Khondoker Alam Darby Kozak Yan Wang Xiaoming Xu Jiwen Zheng Benjamin Rivnay | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 0 |
| 15 | Organic transistor platform with integrated microfluidics for in-line multi-parametric in vitro cell monitoring显示文摘Future drug discovery and toxicology testing could benefit significantly from more predictive and multi-parametric readouts from in vitro models.Despite the recent advances in the field of microfluidics,and more recently organ-on-a-chip technology,there is still a high demand for real-time monitoring systems that can be readily embedded with microfluidics.In addition,multi-parametric monitoring is essential to improve the predictive quality of the data used to inform clinical studies that follow.Here we present a microfluidic platform integrated with in-line electronic sensors based on the organic electrochemical transistor.Our goals are twofold,first to generate a platform to host cells in a more physiologically relevant environment(using physiologically relevant fluid shear stress(FSS))and second to show efficient integration of multiple different methods for assessing cell morphology,differentiation,and integrity.These include optical imaging,impedance monitoring,metabolite sensing,and a wound-healing assay.We illustrate the versatility of this multi-parametric monitoring in giving us increased confidence to validate the improved differentiation of cells toward a physiological profile under FSS,thus yielding more accurate data when used to assess the effect of drugs or toxins.Overall,this platform will enable high-content screening for in vitro drug discovery and toxicology testing and bridges the existing gap in the integration of in-line sensors in microfluidic devices. | Vincenzo F.Curto Bastien Marchiori Adel Hama Anna-Maria Pappa Magali P.Ferro Marcel Braendlein Jonathan Rivnay Michel Fiocchi George G.Malliaras Marc Ramuz Róisín M.Owens | 2017 | Microsystems & Nanoengineering2017，3，1： | 0 |
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