|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Improvements to the retractor and muscle flap design for minimally invasive cochlear implantation显示文摘Objective: The aim of this study was to improve muscle flaps and to evaluate surgical outcomes with the use of a novel specialized retractor, which is a surgical instrument used to locate and shape a bony seat for minimally invasive cochlear implantation.Methods: 50 patients aged 1 e75 years with sensorineural hearing loss who required cochlear implantation were recruited. A small incision(<3 cm) was made, and the novel specialized retractor was used in the study group during cochlear implantation. The incision length, surgical outcomes and operative time were recorded and analyzed.Results: The incision length, total operative time and drilling bony time were shorter in the study group than in the control group(P < 0.05, respectively). All patients recovered well after the surgery without any severe complications.Conclusion: The use of a novel specialized retractor standardized the surgical processes of cochlear implantation. The retractor helped locate and control the size of the bony well during bone drilling. The tool reduced the technical difficulty and improved the efficacy of this minimally invasive operation. | Riyuan Liu Zhiping Tan Jianan Li Yan Yan Wei Ren Miao Zhang Shiming Yang Hui Zhao | 2020 | Journal of Otology2020，15，1： | 1 |
| 2 | Na2S2O4-Mediated Cyclocondensations of 2,2'-Disulfanediyldianilines with Aldehydes: A Facile and Inexpensive Method for the Synthesis of 2-Substituted Benzothiazoles显示文摘为 2 代用品 benzothiazoles 的合成的一个灵巧、便宜的方法被 2,2-disulfanediyldianilines 的调停 Na2S2O4 的 cyclocondensations 与醛开发了。面对 Na2S2O4 并且 4?分子的筛,许多 2 代用品 benzothiazoles 与醛从 2,2-disulfanediyldianilines 的反应被获得在对高收益中等。 | Wang Zhanglin Tang Riyuan Li Jinheng | 2011 | Chinese Journal of Chemistry2011，29，2： | 1 |
| 3 | Effects of nano-devices on growth, quality and activities of enzymes in nitrogen metabolism of hydroponic lettuce 显示文摘 | Guilian Li Riyuan Chen Houcheng Liu | 2014 | Key Engineering Materials2014，701，： | 1 |
| 4 | Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibitionof the NF-κB-mediated VEGF signaling pathway显示文摘 | Hui Chen Jianhong Zhang Jiang Luo Fuji Lai Zhaohong Wang Hongfei Tong Dian Lu Heqi Bu Riyuan Zhang Shengzhang Lin | 2013 | Oncology Reports2013，，2： | 1 |
| 5 | COMBINATIONAL ADMINISTRATION OF AMINOGLYCOSIDES AND LOOP DIURETICS AS AN EFFICIENT STRATEGY TO ESTABLISH DEAFNESS MODELS IN RATS显示文摘It is known that aminoglycoside antibiotics can damage the vestibular and auditory sensory epithelia,and the loop diuretics can enhance the ototoxic effect of aminoglycosides.Previous studies on the synergistic effect of these two types of drugs have used mice,guinea pigs and cats,but not rats.The aim of this study was to determine this synergistic effects in rat cochleae.Rats received intravenous injections of different doses of furosemide and/or intramuscular injections of kanamycin sulfate.Auditory brainstem response(ABR),scanning electron microscopy(SEM)and immunocytochemistry were used to determine the effects of drug administration.In the group receiving combined administration of furosemide and kanamycin,the ABR threshold showed significant elevation 3 days after drug administration,greater than single drug administration.The hair cells showed various degrees of injury from the apical turn to the basal turn of the cochlea and from the outer hair cells to the inner hair cells.Neuron fibers of the hair cells showed significant loss 7 days after the drug administration,but the number of spiral ganglia did not decrease and supporting cells showed no signs of injury.Our study suggest that combined administration of furosemide and kanamycin has an synergistic ototoxic effect,and can result in hair cell loss and hearing loss in rats. | CONG Tao LIU Riyuan YUAN Shuolong XU Liangwei YANG Shiming | 2014 | Journal of Otology2014，9，2： | 0 |
| 6 | Role of BraRGL1 in regulation of Brassica rapa bolting and flowering显示文摘Gibberellin(GA)plays a major role in controlling Brassica rapa stalk development.As an essential negative regulator of GA signal transduction,DELLA proteins may exert significant effects on stalk development.However,the regulatory mechanisms underlying this regulation remain unclear.In this study,we report highly efficient and inheritable mutagenesis using the CRISPR/Cas9 gene editing system in BraPDS(phytoene desaturase)and BraRGL1(key DELLA protein)genes.We observed a loss-of-function mutation in BraRGL1 due to two amino acids in GRAS domain.The flower bud differentiation and bolting time of BraRGL1 mutants were significantly advanced.The expression of GA-regulatory protein(BraGASA6),flowering related genes(BraSOC1,BraLFY),expansion protein(BraEXPA11)and xyloglucan endotransferase(BraXTH3)genes was also significantly upregulated in these mutants.BraRGL1-overexpressing plants displayed the contrasting phenotypes.BraRGL1 mutants were more sensitive to GA signaling.BraRGL1 interacted with BraSOC1,and the interaction intensity decreased after GA3 treatment.In addition,BraRGL1 inhibited the transcription-activation ability of BraSOC1 for BraXTH3 and BraLFY genes,but the presence of GA3 enhanced the activation ability of BraSOC1,suggesting that the BraRGL1-BraSOC1 module regulates bolting and flowering of B.rapa through GA signal transduction.Thus,we hypothesized that BraRGL1 is degraded,and BraSOC1 is released in the presence of GA3,which promotes the expression of BraXTH3 and BraLFY,thereby inducing stalk development in B.rapa.Further,the BraRGL1-M mutant promoted the flower bud differentiation without affecting the stalk quality.Thus,BraRGL1 can serve as a valuable target for the molecular breeding of early maturing varieties. | Yudan Wang Shiwei Song Yanwei Hao Changming Chen Xi Ou Bin He Jiewen Zhang Zhehao Jiang Chengming Li Shuaiwei Zhang Wei Su Riyuan Chen | 2023 | Horticulture Research2023，10，8： | 0 |
| 7 | Growth and Quality of Chinese Kale Grown Under Different LEDs显示文摘[Objective] This study was conducted to investigate the effects of light quality on growth and quality of Chinese kale(Brassica alboglabra Bailey). [Method]Chinese kale was grown in hydroponic under three different Light Emitting Diode(LEDs) conditions [red∶blue=8∶1(8R1B), red∶blue=6∶3(6R3B) and red∶green∶blue=6∶2∶1(6R2G1B), 12 h light, 50 μmol/(m2·s)]. Then its growth and quality indices including root and shoot fresh weight and dry weight, concentrations of soluble protein, vitamin C, nitrate, soluble phenols, flavonoids, soluble sugar, free amino acids, and activity of nitrate reductase were measured. [Result] There was no significant difference in plant height, diameter of flower stalk and leaf number among three LED treatments. The fresh weight of shoot, root and plant in 8R1 B and 6R2G1 B was significantly higher than in 6R3 B. The dry weight of shoot and plant in 8R1 B was significantly higher than in 6R3 B. The concentrations of vitamin C, soluble protein and soluble sugar in flower stalk of 6R3 B treatment were significantly higher than those in 8R1 B and 6R2G1 B, while there was no remarkable difference in concentrations of reducing sugar, soluble phenol, flavonoids and free amino acid among the three treatments. The nitrate concentration in flower stalk of 6R3 B was significantly lower than in the other two treatments, and the activity of nitrate reductase in6R3 B was significantly higher than in the other two treatments. [Conclusion] The LED treatment of red:blue=6:3 was more suitable for the growth of Chinese kale. | Jintong XIN Houcheng LIU Shiwei SONG Riyuan CHEN Guangwen SUN | 2015 | Agricultural Science & Technology2015，16，1： | 0 |
| 8 | The SlTPL3–SlWUS module regulates multi-locule formation in tomato by modulating auxin and gibberellin levels in the shoot apical meristem显示文摘Malformed fruits depreciate a plant’s market value.In tomato(Solanum lycopersicum),fruit malformation is associated with the multi-locule trait,which involves genes regulating shoot apical meristem(SAM)development.The expression pattern of TOPLESS3(SITPL3)throughout SAM development prompted us to investigate its functional significance via RNA interference(RNAi)and clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9(Cas9)-mediated gene editing.Lower SITPL3 transcript levels resulted in larger fruits with more locules and larger SAMs at the 5 d after germination(DAG5)stage.Differentially expressed genes in the SAM of wild-type(WT)and SITPL3-RNAi plants,identified by transcriptome deep sequencing(RNA-seq),were enriched in the gibberellin(GA)biosynthesis and plant hormone signaling pathways.Moreover,exogenous auxin and paclobutrazol treatments rescued the multi-locule phenotype,indicating that SITPL3 affects SAM size by mediating auxin and GA levels in the SAM.Furthermore,SITPL3 interacted with WUSCHEL(SIWUS),which plays an important role in SAM size maintenance.We conducted RNA-seq and DNA affinity purification followed by sequencing(DAP-seq)analyses to identify the genes regulated by SITPL3 and SIWUS in the SAM and to determine how they regulate SAM size.We detected24 overlapping genes regulated by SITPL3 and SIWUS and harboring an SIWUS-binding motif in their promoters.Furthermore,functional annotation revealed a notable enrichment for functions in auxin transport,auxin signal transduction,and GA biosynthesis.Dual-luciferase assays also revealed that SITPL3 enhances SIWUS-mediated regulation(repression and activation)of SIPIN3 and SIGA2 ox4 transcription,indicating that the SITPL3-SIWUS module regulates SAM size by mediating auxin distribution and GA levels,and perturbations of this module result in enlarged SAM.These results provide novel insights into the molecular mechanism of SAM maintenance and locule formation in tomato and highlight the SITPL3-SIWUS module as a key regulator. | Shiwei Song Binbin Huang Zanlin Pan Qiuxiang Zhong Yinghua Yang Da Chen Lisha Zhu Guojian Hu Mi He Caiyu Wu Mohammed Zouine Riyuan Chen Mondher Bouzayen Yanwei Hao | 2022 | Journal of Integrative Plant Biology2022，64，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员