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| 1 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 2 | A single-radar technique for Estimating the Winds in Tropical Cyclones显示文摘 | Robert Gall | 1999 | Bulletin of the American Meteorological Society1999，80，4： | 1 |
| 3 | Irritable bowel syndrome and organic diseases: A comparative analysis of esophageal motility显示文摘AIM:To assess the esophageal motility in patients with irritable bowel syndrome(IBS)and to compare those with patients with autoimmune disorders.METHODS:15 patients with IBS,22 with systemic lupus erythematosus(SLE)and 19 with systemic sclerosis(SSc)were prospectively selected from a total of 115patients at a single university centre and esophageal motility was analysed using standard manometry(Mui Scientific PIP-4-8SS).All patients underwent esophagogastro-duodenoscopy before entering the study so that only patients with normal endoscopic findings were included in the current study.All patients underwent a complete physical,blood biochemistry and urinary examination.The grade of dysphagia was determined for each patient in accordance to the intensity and frequency of the presented esophageal symptoms.Furthermore,disease activity scores(SLEDAI and modified Rodnan score)were obtained for patients with autoimmune diseases.Outcome parameter:A correlation coefficient was calculated between amplitudes,velocity and duration of the peristaltic waves throughout esophagus and patients’dysphagia for all three groups.RESULTS:There was no statistical difference in the standard blood biochemistry and urinary analysis in all three groups.Patients with IBS showed similar pathologic dysphagia scores compared to patients with SLE and SSc.The mean value of dysphagia score was in IBS group 7.3,in SLE group 6.73 and in SSc group7.56 with a P-value>0.05.However,the manometric patterns were different.IBS patients showed during esophageal manometry peristaltic amplitudes at the proximal part of esophagus greater than 60 mmHg in46%of the patients,which was significant higher in comparison to the SLE(11.8%)and SSc-Group(0%,P=0.003).Furthermore,IBS patients showed lower mean resting pressure of the distal esophagus sphincter(Lower esophageal sphincter,22 mmHg)when compared with SLE(28 mmHg,P=0.037)and SSc(26 mmHg,P=0.052).23.5%of patients with SLE showed amplitudes greater as 160 mmHg in the distal esophagus(IBS and SSc:0%)whereas 29.4%amplitudes greater as 100 mmHg in the middle one(IBS:16.7%,SSc:5.9%respectively,P=0.006).Patients with SSc demonstrated,as expected,in almost half of the cases reduced peristalsis or even aperistalsis in the lower two thirds of the esophagus.SSc patients demonstrated a negative correlation coefficient between dysphagia score,amplitude and velocity of peristaltic activity at middle and lower esophagus[r=-0.6,P | Thomas Thomaidis Martin Goetz Sebastian Paul Gregor Arthur Hoffman Elias Kouroumalis Markus Moehler Peter Robert Galle Andreas Schwarting Ralf Kiesslich | 2013 | World Journal of Gastroenterology2013，19，38： | 1 |
| 4 | Preferential incorporation of coloured-carotenoids occurs in the LH2 complexes from non-sulphur purple bacteria under carotenoid-limiting conditions显示文摘 | Gall A Henry S Takaichi S Robert B Cogdell RJ | | 0，，1： | 1 |
| 5 | Preferential incorporation of coloured-carotenoids occurs in the LH2 complexes from non-sulphur purple bacteria under carotenoid-limiting conditions显示文摘 | Gall A Henry S Takaichi S Robert B Cogdell RJ | 2005 | Photosynth Res2005，86，12： | 1 |
| 6 | Morphologic physiologic correlates of the severity of fibrosis and degree of cellularity,in idiopathic pulmonary fibrosis显示文摘 | Fulmer JD Roberts WC Von Gall ER | 1998 | Clin Invest1998，63，3： | 1 |
| 7 | Advances in vocational theory and research: a 20-years retrospective显示文摘 | Gall Hackert Robert W Lent& Jeffrey H Greenhaus | 1991 | Journal of Vocational Behavior1991，，38： | 1 |
| 8 | Improving Competitiveness through Supply Chain Management: A Cumulative Improvement Approach 显示文摘 | Robert J Volurka Gall M Zank | 2002 | Competitiveness Review2002，12，1： | 1 |
| 9 | The Shape of Ground Motion At- tenuation Curves in Southeastern Canada显示文摘 | Gall M Atkinson Robert F | 1992 | Bull Seism Soc Am1992，82，5： | 1 |
| 10 | A metallization and bonding approach for high performance carbon nanotube thermalinterface materials显示文摘 | Robert Cross Baratunde A Cola Timothy Fisher Xianfan Xu Ken Gall Samuel Graham | 2010 | Nanotechnology2010，，44： | 1 |
| 11 | Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells显示文摘 | Martin Franz Sprinzl Florian Reisinger Andreas Puschnik Marc Ringelhan Kerstin Ackermann Daniel Hartmann Matthias Schiemann Arndt Weinmann Peter Robert Galle Marcus Schuchmann Helmut Friess Gerd Otto Mathias Heikenwalder Ulrike Protzer | 2013 | Hepatology2013，，： | 1 |
| 12 | The role of the GGGX motif in determining the activity and enantioselectivity of pig liver esterase towards tertiary alcohols显示文摘 | Markus Gall Robert Kourist Marlen Schmidt Uwe T. Bornscheuer | 2010 | Biocatalysis and Biotransformation2010，，3： | 1 |
| 13 | Intraprocedural bowel cleansing with the Jet Prep cleansing system improves adenoma detection显示文摘AIM: To investigate the impact of Jet Prep cleansing on adenoma detection rates.METHODS: In this prospective,randomized,crossover trial,patients were blindly randomized to an intervention arm or a control arm.In accordance with the risk profile for the development of colorectal carcinoma,the study participants were divided into high-risk and low-risk groups.Individuals with just one criterion(age > 70 years,adenoma in medical history,and first-degree relative with colorectal cancer) were regarded as high-risk patients.Bowel preparation was performed in a standardized manner one day before the procedure.Participants in the intervention arm underwent an initial colonoscopy with standard bowel cleansing using a 250-m L syringe followed by a second colonoscopy that included irrigation by the use of the Jet Prep cleansing system.The reverse sequence was used in the control arm.The study participants were divided into a high-risk group and a low-risk group according to their respective risk profiles for the development of colorectal carcinoma.RESULTS: A total of 64 patients(34 men and 30 women) were included in the study; 22 were included in the high-risk group.After randomization,30 patients were assigned to the control group(group A) and 34 to the intervention group(group B).The average Boston Bowel Preparation Scale score was 5.15 ± 2.04.The withdrawal time needed for the first step was significantly longer in group A using the Jet Prep system(9.41 ± 3.34 min) compared to group B(7.5 ± 1.92 min).A total of 163 polyps were discovered in 64 study participants who underwent both investigation steps.In group A,49.4% of the polyps were detected during the step of standard bowel cleansing while the miss rate constituted 50.7%.Group B underwent cleansing with the Jet Prep system during the first examination step,and as many as 73.9% of polyps were identified during this step.Thus,the miss rate in group B was a mere 26.1%(P < 0.001).When considering only the right side of the colon,the miss rate in group A during the first examination was 60.6%,in contrast to a miss rate of 26.4% in group B(P < 0.001).CONCLUSION: Jet Prep is recommended for use during colonoscopy because a better prepared bowel enables a better adenoma detection,particularly in the proximal colon. | Arthur Hoffman Sanjay Murthy Lena Pompetzki Johannes Wilhelm Rey Martin Goetz Achim Tresch Peter Robert Galle Ralf Kiesslich | 2015 | World Journal of Gastroenterology2015，21，26： | 0 |
| 14 | Mini-laparoscopy in the endoscopy unit:Safety and outcomes in over one thousand patients显示文摘AIM:To investigate the safety of consecutive mini-lapar oscopy guided liver biopsies for the diagnosis and staging of liver diseases. METHODS: In this study we retrospectively analyzed the safety of mini-laparoscopic liver biopsy performed in an endoscopy unit in 1071 patients. We measured the incidence of bleeding and evaluated the management and outcome of bleeding interventions.were viral hepatitis and autoimmune liver disease. 250 patients had macroscopically and histologically proven cirrhosis. 13 patients had no pathological f indings. 33% of all patients had bleeding that required argon plasma coagulation of the puncture site during laparoscopy. Signif icant bleeding occurred more often in patients with liver cirrhosis compared to non-cirrhotic liver dise ases but was effectively treated with laparoscopic coag ulation. CONCLUSION: In conclusion, mini-laparoscopy liver biopsy can be performed safely and effectively in high risk patients with advanced liver disease; mini-lapar osc opy with liver biopsy can be done safely in an endos copy unit. | Arthur Hoffman Fareed Rahman Sarah Prengel Marcus Schuchmann Martin Gotz Markus Moehler Peter Robert Galle Ziping Li Anthony Nicolas Kalloo Ralf Kiesslich | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，1： | 0 |
| 15 | 行非紧急经皮冠状动脉介入治疗的患者使用SCH530348的安全性和耐受性:一项随机、双盲、安慰剂对照Ⅱ期研究显示文摘背景行经皮冠状动脉介入术(PCI)的患者需要抗血栓药物治疗,以安全地减少心血管事件的发生。、为此作者评价了患者使用SCH530348(一种口服的血小板蛋白酶激活受体l拮抗剂)的耐受性和安全性。方法在国际多中心研究中,将接受非紧急PCI或拟行PCI而行冠状动脉造影的患者(年龄≥45岁)以3:1的比例随机分配至口服负荷剂量SCH530348组.(10mg、20mg或40mg)或匹配的安慰刺组。SCH530348组中随后行PCI的患者(主要PCI队列)继续口服维持剂量(每天0.5mg、1.0mg或2.5mg),而安慰剂纽患者则继续服用安慰剂.共60d。主要终点是根据心肌梗死溶栓(TIMI)试验量表确定的有临床意义的大出血和少量出血。研究人员和患者均不知晓治疗分组情况。采用意向性治疗分析。本研究已在Clinical Trials.gov注册,注册号为NCT00132912。结果257例患者被分配至安慰剂组,773例患者被分配至SCH530348组,在SCH53034810mg、20mg和40mg组中,主要终点的发生率分别为2/129(3%)、3/120(3%)和7/173(7%).而安慰剂组中,主要终点的发生率为5/151(3%;P=0.5786)。在每天口服SCH530348O.5mg、1.0mg和2.5mg的患者中,TIMI大出血和少量出血的发生率分别为3/136(2%)、5/139(4%)和4/138(3%)(P=0.7651)。结论即使同时合并应用阿司匹林和氯吡格雷,患者仍能很好地耐受口服SCH530348,并且不导TIMI出血的增加。进一步验证以精确规定SCH530348的安全性和有效性的Ⅲ期临床试验已获得批准。 | Richard C Becker David J Moliterno Lisa K Jennings Karen S Pieper Jinglan Pei Alan Niederman Khaled M Ziada Gall Berman John Strony Diane Joseph Kenneth W Mahaff ey Frans Van de Were Enrico Veltri Robert A Harrington 徐景涛(译) | 2009 | 世界临床医学2009，，10： | 0 |
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